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American Society for Clinical Pathology (ASCP) Medical Laboratory Scientist (MLS) Certification Exam EXAM STUDY GUIDE 2026/2027 ACCURATE QUESTIONS WITH CORRECT DETAILED SOLUTIONS || 100% GUARANTEED PASS NEWEST VERSION

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American Society for Clinical Pathology (ASCP) Medical Laboratory Scientist (MLS) Certification Exam EXAM STUDY GUIDE 2026/2027 ACCURATE QUESTIONS WITH CORRECT DETAILED SOLUTIONS || 100% GUARANTEED PASS NEWEST VERSION

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ASCP Board of Certification MLS Practice Questions
Study online at https://quizlet.com/_a1rfpk

1. Clinically insignif- The immediate spin phase of an indirect antiglobulin test (antibody screen and
icant cold an- antibody identification) could most likely lead to the detection of what?
tibodies antibod-
ies

2. Micosporum can-
is




3. Albumin Which analyte measurement is used to detect early nephropathy in a diabetic
patient?

4. 32 grams In order to correctly prepare a 4 M solution of NaOH, how many grams need to
be added to 200 mL of solution? (GMW NaOH =40 g)

5. Russell bodies What are the globular inclusions in this cell?




6. This represents A urine concentration test was performed on a patient after a fluid intake depri-
normal kidney vation period with the following findings:
function After 12 hours Urine Osmolality = 850 mOsm/KgAfter 16 hours Urine Osmolality
= 850 mOsm/Kg
What do these results indicate?

7. Nucleolar This antinuclear antibody (ANA) test is viewed using fluorescent microscopy, which
pattern is this?



, ASCP Board of Certification MLS Practice Questions
Study online at https://quizlet.com/_a1rfpk




8. Corynebacteri- Which species of Corynebacterium is lipophilic?
um jeikeium

9. Systematic error If a commercial lyophilized reagent is diluted using slightly more distilled water
than indicated, what type of error will occur?

10. Hereditary sphe- The autohemolysis test is MOST useful in the diagnosis of which condition?
rocytosis

11. Clinical Chem- Which clinical laboratory department performs the most tests?
istry

12. Quantitative fe- Which test requires a 72-hour stool (fecal) collection?
cal fat

13. There is no dis- Which antinuclear antibody (ANA) pattern is seen in the image on the right, which
cernable pattern represents the result of an ANA test viewed using fluorescent microscopy?




14. A From the IgG molecule illustration, which region is the heavy chain?






, ASCP Board of Certification MLS Practice Questions
Study online at https://quizlet.com/_a1rfpk

15. Lactobacillus From the choices listed below, which organism is classified as an aerotolerant
species anaerobe?

Clostridium novyi
Staphylococcus aureus
Lactobacillus species
Neisseria species

16. Efficiency The number of patients correctly diagnosed for the disease or not having the
disease is defined as:

17. Cannot report A manual white blood cell count was performed by the hematology technologist.
The cell counts for both sides were 99 and 164 respectively. All nine large squares
were counted on each side. The dilution for this kit was pre-measured at 1:100.
What should the technologist report as the white cell count?

18. Candida glabrata This species of Candida accounts for around 20 percent of urinary yeast isolates.

19. Positive DAT Which finding best distinguishes immune hemolytic anemia from other hemolytic
anemias?

20. Phosphorus Which analyte shows no difference between capillary and venous values?

21. Amylase Which blood test is used to determine acute pancreatitis?

22. Anti-Leb If detected in antibody screen testing, which of the following antibodies is NOT
considered clinically significant in prenatal patients?

23. Brown/black Homogentisic acid in urine will cause urine to be which color?

24. Type IV Cell me- The type of hypersensitivity reaction associated with macrophage activation, cy-
diated hypersen- tokine-mediated inflammation is:
sitivity (T-cell de-
pendent)


, ASCP Board of Certification MLS Practice Questions
Study online at https://quizlet.com/_a1rfpk

25. Reliability The degree in which a measure is consistent in producing the same results when
measuring the same analyte is called:

26. Lymphocytes A college student is treated in the hospital for suspected meningitis. Which cells
should be identified in the cerebrospinal fluid (CSF) report for the cytospin field
that is shown?




27. Sodium What contributes most to serum osmolality:

28. Lesions caused Identify a characteristic of an organ-non specific disorder that distinguishes it
by deposition from an organ specific disorder.
of antigen-an-
tibody immune
complexes

29. ABO/Rh, DAT What is the recommended routine testing to be performed on a newborn of a
and/or antibody group B Rh positive female?
screening are
NOT routinely
performed in this
scenario.

30. Microcytic, A patient has the following hematology test results. Classify the anemia:
hypochromic Hgb = 8.1 g/dL
Hct = 31%
RBC = 4.0 x 1012/L

31. Bacillus anthracis

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