MRCP OFFICIAL SAMPLE QUESTIONS | PRACTICE QUESTIONS & ANSWERS |
COMPREHENSIVE MRCP STUDY GUIDE 2026/2027
A - correct answer ✔✔A 65-year-old woman presented with a 12-hour history of the sudden
onset of gait unsteadiness, vomiting and headache, followed by increasing drowsiness.
What is the most likely diagnosis?
A: acute cerebellar hemorrhage
B: acute subdural haemorrhage
C: frontal subdural empyema
D: herpes simplex encephalitis
E: pituitary apoplexy
E - correct answer ✔✔A post-marketing observational study of a new drug was conducted on
5000 patients following clinical trials.
What best describes the data generated from this type of study?
A: comparative efficacy
B: cost-benefit
,C: cost effectiveness
D: potency
E: profile of adverse effects
B - correct answer ✔✔A 79-year-old woman was admitted for elective hip replacement surgery.
On examination, she was pale. There was 2-cm splenomegaly and there were small discrete
axillary lymph nodes.
haemoglobin 107 g/L (115-165)
white cell count 34.5 × 109/L (4.0-11.0)
platelet count 183 × 109/L (150-400)
What is the most likely diagnosis?
A: acute myeloid leukaemia
B: chronic lymphocytic leukaemia
C: chronic myeloid leukaemia
D: myelodysplasia
E: myelofibrosis
,D - correct answer ✔✔A 17-year-old boy presented with a non-blanching rash over his legs, a
swollen knee and painless, visible haematuria.
Urinalysis showed blood 3+, protein 1+.
serum creatinine 210 µmol/L (60-110) urine culture negative ultrasound scan of kidneys normal
What glomerular abnormality is most likely to be present at renal biopsy?
A: focal segmental sclerosis
B: foot process fusion
C: linear deposition of IgG on the basement membrane
D: mesangial deposition of IgA
E: thickening of basement membranes
E - correct answer ✔✔A 75-year-old woman developed a spreading cellulitis on her left leg
secondary to ulceration.
blood cultures MRSA
In addition to vancomycin, what is the most appropriate antibiotic?
, A: amoxicillin
B: azithromycin
C: flucloxacillin
D: metronidazole
E: rifampicin
A - correct answer ✔✔A 45-year-old woman presented with right flank pain. She had a 4-year
history of hypertension and progressive cognitive impairment.
On examination, she had livedo reticularis and tenderness in the right flank. Her BP was
185/105 mmHg. Urinalysis showed blood 3+, protein 1+.
Hb 129 g/L (115-165) WCC 8.7 × 109/L (4.0-11.0) PlTs 83 × 109/L (150-400)
serum creatinine 106 µmol/L (60-110)
What antibody test is most likely to be positive?
A: anticardiolipin
B: anticentromere
C: anti-glomerular basement membrane
COMPREHENSIVE MRCP STUDY GUIDE 2026/2027
A - correct answer ✔✔A 65-year-old woman presented with a 12-hour history of the sudden
onset of gait unsteadiness, vomiting and headache, followed by increasing drowsiness.
What is the most likely diagnosis?
A: acute cerebellar hemorrhage
B: acute subdural haemorrhage
C: frontal subdural empyema
D: herpes simplex encephalitis
E: pituitary apoplexy
E - correct answer ✔✔A post-marketing observational study of a new drug was conducted on
5000 patients following clinical trials.
What best describes the data generated from this type of study?
A: comparative efficacy
B: cost-benefit
,C: cost effectiveness
D: potency
E: profile of adverse effects
B - correct answer ✔✔A 79-year-old woman was admitted for elective hip replacement surgery.
On examination, she was pale. There was 2-cm splenomegaly and there were small discrete
axillary lymph nodes.
haemoglobin 107 g/L (115-165)
white cell count 34.5 × 109/L (4.0-11.0)
platelet count 183 × 109/L (150-400)
What is the most likely diagnosis?
A: acute myeloid leukaemia
B: chronic lymphocytic leukaemia
C: chronic myeloid leukaemia
D: myelodysplasia
E: myelofibrosis
,D - correct answer ✔✔A 17-year-old boy presented with a non-blanching rash over his legs, a
swollen knee and painless, visible haematuria.
Urinalysis showed blood 3+, protein 1+.
serum creatinine 210 µmol/L (60-110) urine culture negative ultrasound scan of kidneys normal
What glomerular abnormality is most likely to be present at renal biopsy?
A: focal segmental sclerosis
B: foot process fusion
C: linear deposition of IgG on the basement membrane
D: mesangial deposition of IgA
E: thickening of basement membranes
E - correct answer ✔✔A 75-year-old woman developed a spreading cellulitis on her left leg
secondary to ulceration.
blood cultures MRSA
In addition to vancomycin, what is the most appropriate antibiotic?
, A: amoxicillin
B: azithromycin
C: flucloxacillin
D: metronidazole
E: rifampicin
A - correct answer ✔✔A 45-year-old woman presented with right flank pain. She had a 4-year
history of hypertension and progressive cognitive impairment.
On examination, she had livedo reticularis and tenderness in the right flank. Her BP was
185/105 mmHg. Urinalysis showed blood 3+, protein 1+.
Hb 129 g/L (115-165) WCC 8.7 × 109/L (4.0-11.0) PlTs 83 × 109/L (150-400)
serum creatinine 106 µmol/L (60-110)
What antibody test is most likely to be positive?
A: anticardiolipin
B: anticentromere
C: anti-glomerular basement membrane
