CSB601 Exam Questions with Correct Answers
The role of TGA
Part of Department of Health that regulates therapeutic goods
What classify as therapeutic goods
Medicines and blood products, Medical devices, Biologicals
Difference between AUST R, AUST L and AUST L(A)
AUST R - registered high risk medicines that requires pre-market assessment
AUST L - contemporary medicines that hasn't been been assessed for efficacy
AUST LA - listed medicines that had to provide proof of
Principles of QUM
Safety
Efficacy
Appropriate
Judicious
What are generic brands of medications
Medication that has been proved to have the bioavailability of the branded drugs
Problems with Medication
Adverse medicine events
Adverse medicine reactions
Inappropriate selection
Dosing
w/o indication
,Interactions
Untreated indications
Pharmacokinetics
what the body does to the drug (ADME)
What is pharmacodynamics?
What the drug does to the body
- intended effect
- side effect
What does ADME stand for in pharmacokinetics?
Absorption: oral, sublingual, blood vessel, GIT
Distribution: Blood vessel, Lymphatic vessel, CNS fluid
Metabolism: Liver, Kidney, Lung
Excretion: Kidney
Bioavailability
A measure (%) of the extent of drug absorption from site of administration and site of action
for a given drug and route.
What is half-life of a medication
The time it takes for plasma concentration of a drug to decrease by half, which determines the
dosing frequency
Interactions between Digoxin and potassium-losing diuretics
Increase arrhythmias, since potassium-losing diuretics can result in potassium depletion
What medication interacts with NSAIDs
,- ACE-inhibitors (Decrease effects)
- Diuretics (Decrease effects)
- Sulfonylureas (Increase hypoglycemic effect)
- Lithium (toxicity)
- Digoxin
Key parameters of Pharmacokinetic
- Half Life
- Volume of Distribution
- Bioavailability
- Clearance
Classes of Antidepressants
SSRIs, SNRIs, TCAs, MAOIs
What class of drugs is Phenelzine and Tranylcypromine
MAOIs
Drug class: Fluvoxamine, Sertraline
SSRIs
Interaction: SSRIs/SNRIs with NSAIDs
Increase risk of bleeding
Interaction: SSRIs/SNRIs with Tramadol
Increase risk of Serotonin Syndrome
What are precautions of lithium use in women
, - Increase the risk of congenital heart defects in pregnancy, neonatal neurotoxicity and
hypothyroidism
- Lithium concentration in pregnancy
What the triple whammy of the medications
ACE-inhibitors
Diuretics
NSAIDs
- Causing increased risk in AKI
Interaction between diuretics and ACE inhibitors/ARBs
postural hypotension
What's the symptoms of Serotonin Toxicity
- Increased temperature
- Agitation
- Tremor
- Palpitations
- sweating
- diarrhea
- mania
Drugs that can contribute to serotonin toxicity
Antidepressants
Opioids
St. john's Wort
Illicit drugs
The role of TGA
Part of Department of Health that regulates therapeutic goods
What classify as therapeutic goods
Medicines and blood products, Medical devices, Biologicals
Difference between AUST R, AUST L and AUST L(A)
AUST R - registered high risk medicines that requires pre-market assessment
AUST L - contemporary medicines that hasn't been been assessed for efficacy
AUST LA - listed medicines that had to provide proof of
Principles of QUM
Safety
Efficacy
Appropriate
Judicious
What are generic brands of medications
Medication that has been proved to have the bioavailability of the branded drugs
Problems with Medication
Adverse medicine events
Adverse medicine reactions
Inappropriate selection
Dosing
w/o indication
,Interactions
Untreated indications
Pharmacokinetics
what the body does to the drug (ADME)
What is pharmacodynamics?
What the drug does to the body
- intended effect
- side effect
What does ADME stand for in pharmacokinetics?
Absorption: oral, sublingual, blood vessel, GIT
Distribution: Blood vessel, Lymphatic vessel, CNS fluid
Metabolism: Liver, Kidney, Lung
Excretion: Kidney
Bioavailability
A measure (%) of the extent of drug absorption from site of administration and site of action
for a given drug and route.
What is half-life of a medication
The time it takes for plasma concentration of a drug to decrease by half, which determines the
dosing frequency
Interactions between Digoxin and potassium-losing diuretics
Increase arrhythmias, since potassium-losing diuretics can result in potassium depletion
What medication interacts with NSAIDs
,- ACE-inhibitors (Decrease effects)
- Diuretics (Decrease effects)
- Sulfonylureas (Increase hypoglycemic effect)
- Lithium (toxicity)
- Digoxin
Key parameters of Pharmacokinetic
- Half Life
- Volume of Distribution
- Bioavailability
- Clearance
Classes of Antidepressants
SSRIs, SNRIs, TCAs, MAOIs
What class of drugs is Phenelzine and Tranylcypromine
MAOIs
Drug class: Fluvoxamine, Sertraline
SSRIs
Interaction: SSRIs/SNRIs with NSAIDs
Increase risk of bleeding
Interaction: SSRIs/SNRIs with Tramadol
Increase risk of Serotonin Syndrome
What are precautions of lithium use in women
, - Increase the risk of congenital heart defects in pregnancy, neonatal neurotoxicity and
hypothyroidism
- Lithium concentration in pregnancy
What the triple whammy of the medications
ACE-inhibitors
Diuretics
NSAIDs
- Causing increased risk in AKI
Interaction between diuretics and ACE inhibitors/ARBs
postural hypotension
What's the symptoms of Serotonin Toxicity
- Increased temperature
- Agitation
- Tremor
- Palpitations
- sweating
- diarrhea
- mania
Drugs that can contribute to serotonin toxicity
Antidepressants
Opioids
St. john's Wort
Illicit drugs
