Oncology Exam 1 with all Correct & 100% Verified
Answers |Actual Complete Update |Already Graded A+
(Just Released)
The cytoskeleton consists of
a. Microtubules
b. Microfilaments
c. Intermediate filaments
d. All of these ✔Correct Answer-D
_____ are microtubule inhibitors that bind to & inhibit Beta-tubulin, which prevents
microtubule polymerization & mitotic spindle formation
a. Vinblastine and vincristine
b. Paclitaxel and Docetaxel
c. Both1&2
d. None of these ✔Correct Answer-A
As opposed to taxane, resistance to Vinca alkaloids has been associated
a. Increased class II Beta-tubulin expression
b. Decreased class II Beta-tubulin expression
c. No change in class II Beta-tubulin expression
d. None of these ✔Correct Answer-B
Mechanism of action of Taxanes and Vinca Alkaloids occur at
a. G1 phase
b. G2 phase
c. M phase
d. S phase ✔Correct Answer-C
Mitotic motor protein inhibitors are
a. Vinblastine
b. Paclitaxel
c. Vincristine
d. Aurora kinase inhibitors ✔Correct Answer-D
Drug resistance is often complex and can often involve diverse mechanisms, such as
a. Factors that reduce the ability of drugs to reach their cellular targets
b. Modification in the drug target
c. Events downstream of the target (exp: decreased sensitivity to, or defective, signal)
d. All of the above ✔Correct Answer-D
, Paclitaxel is an antineoplastic drug that exerts its function by acting as:
A. Microtubule stabilizer
B. G1 phase cell cycle inhibitor
C. G2 phase cell cycle inhibitor
D. S phase cell cycle inhibitor ✔Correct Answer-A
Which of the following is associated with more neurotoxicity
a. vincristine
b. vinblastine
c. vinorelbine
d. vindesine ✔Correct Answer-A
Centrioles are made up of
a. 9 sets of microtubule triplets
b. 12 sets of microtubule triplets
c. 15 sets of microtubule triplets
d. 6 sets of microtubule triplets ✔Correct Answer-A
To which organ region of a gene does an RNA polymerase bind to initiate transcription?
a. 5' UTR
b. 3' UTR
c. CDS
d. Promoter ✔Correct Answer-D
ACpG island consists of about 2000 copies of the CG dinucleotide
a. True
b. False ✔Correct Answer-A
Methylation of CpG islands
a. Enhance binding of regulatory transcription factors
b. Prevents activation of enhancers
c. Prevents binding of chromatin remodeling proteins
d. Interferes directly with RNA polymerase binding ✔Correct Answer-B
Which of the following is not true about CpG islands?
A.Frequently occurring
B.Long DNA sequences
C.Low CG dinucleotide content
D.Frequently associated with transcription start sites
E.B&C ✔Correct Answer-E
What enzyme copies methylation marks from the parenteral to the daughter strand of DNA?
A. DNMT1
Answers |Actual Complete Update |Already Graded A+
(Just Released)
The cytoskeleton consists of
a. Microtubules
b. Microfilaments
c. Intermediate filaments
d. All of these ✔Correct Answer-D
_____ are microtubule inhibitors that bind to & inhibit Beta-tubulin, which prevents
microtubule polymerization & mitotic spindle formation
a. Vinblastine and vincristine
b. Paclitaxel and Docetaxel
c. Both1&2
d. None of these ✔Correct Answer-A
As opposed to taxane, resistance to Vinca alkaloids has been associated
a. Increased class II Beta-tubulin expression
b. Decreased class II Beta-tubulin expression
c. No change in class II Beta-tubulin expression
d. None of these ✔Correct Answer-B
Mechanism of action of Taxanes and Vinca Alkaloids occur at
a. G1 phase
b. G2 phase
c. M phase
d. S phase ✔Correct Answer-C
Mitotic motor protein inhibitors are
a. Vinblastine
b. Paclitaxel
c. Vincristine
d. Aurora kinase inhibitors ✔Correct Answer-D
Drug resistance is often complex and can often involve diverse mechanisms, such as
a. Factors that reduce the ability of drugs to reach their cellular targets
b. Modification in the drug target
c. Events downstream of the target (exp: decreased sensitivity to, or defective, signal)
d. All of the above ✔Correct Answer-D
, Paclitaxel is an antineoplastic drug that exerts its function by acting as:
A. Microtubule stabilizer
B. G1 phase cell cycle inhibitor
C. G2 phase cell cycle inhibitor
D. S phase cell cycle inhibitor ✔Correct Answer-A
Which of the following is associated with more neurotoxicity
a. vincristine
b. vinblastine
c. vinorelbine
d. vindesine ✔Correct Answer-A
Centrioles are made up of
a. 9 sets of microtubule triplets
b. 12 sets of microtubule triplets
c. 15 sets of microtubule triplets
d. 6 sets of microtubule triplets ✔Correct Answer-A
To which organ region of a gene does an RNA polymerase bind to initiate transcription?
a. 5' UTR
b. 3' UTR
c. CDS
d. Promoter ✔Correct Answer-D
ACpG island consists of about 2000 copies of the CG dinucleotide
a. True
b. False ✔Correct Answer-A
Methylation of CpG islands
a. Enhance binding of regulatory transcription factors
b. Prevents activation of enhancers
c. Prevents binding of chromatin remodeling proteins
d. Interferes directly with RNA polymerase binding ✔Correct Answer-B
Which of the following is not true about CpG islands?
A.Frequently occurring
B.Long DNA sequences
C.Low CG dinucleotide content
D.Frequently associated with transcription start sites
E.B&C ✔Correct Answer-E
What enzyme copies methylation marks from the parenteral to the daughter strand of DNA?
A. DNMT1
