WORKING WITH THE IACUC COMPREHENSIVE EXAM
2026/2027 QUESTIONS AND SOLUTIONS RATED A+
✔✔Which of the following is best used as a source of guidelines for animals housed in
farm settings? - ✔✔Guide for the Care and Use of Agricultural Animals in Research and
Teaching
✔✔An investigator wishes to use animals in an experiment that involves USDA pain
category B, C, and D activities performed on the same animal. How should the animal
be categorized? - ✔✔Category D
✔✔Which of the following activities WOULD place an animal in category E? - ✔✔Lethal
dose experiments in which animals are allowed to die without intervention
✔✔Which of the following is NOT a reason to provide environmental enrichment? -
✔✔To supplement the nutritional deficiencies of standard animal chow
✔✔An agent that has high individual risk but low community risk would be in which Risk
Group per the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic
Acid Molecules? - ✔✔Risk Group 3
✔✔What does the acronym IACUC stand for? - ✔✔Institutional Animal Care and Use
Committee
✔✔When does the postoperative period end? - ✔✔10-14 days
✔✔Which of the following statements regarding the use of restraint on animals in a
research study is FALSE? - ✔✔Restraint can be used as a normal component of animal
housing
✔✔The three Rs of Russell and Burch stand for what? - ✔✔Replacement, reduction,
and refinement
✔✔Which of the following statements about postoperative care records is TRUE? -
✔✔For rodents, postoperative records for the group may be kept on cage cards or in
laboratory notebooks.
✔✔Endpoint criteria describe when it is time to do what? - ✔✔Intervene to remove an
animal from a study, sometimes by euthanizing an animal
✔✔Prior to IACUC review of the animal use protocol application that describes
procedures that are expected to cause more than momentary pain or distress, which of
2026/2027 QUESTIONS AND SOLUTIONS RATED A+
✔✔Which of the following is best used as a source of guidelines for animals housed in
farm settings? - ✔✔Guide for the Care and Use of Agricultural Animals in Research and
Teaching
✔✔An investigator wishes to use animals in an experiment that involves USDA pain
category B, C, and D activities performed on the same animal. How should the animal
be categorized? - ✔✔Category D
✔✔Which of the following activities WOULD place an animal in category E? - ✔✔Lethal
dose experiments in which animals are allowed to die without intervention
✔✔Which of the following is NOT a reason to provide environmental enrichment? -
✔✔To supplement the nutritional deficiencies of standard animal chow
✔✔An agent that has high individual risk but low community risk would be in which Risk
Group per the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic
Acid Molecules? - ✔✔Risk Group 3
✔✔What does the acronym IACUC stand for? - ✔✔Institutional Animal Care and Use
Committee
✔✔When does the postoperative period end? - ✔✔10-14 days
✔✔Which of the following statements regarding the use of restraint on animals in a
research study is FALSE? - ✔✔Restraint can be used as a normal component of animal
housing
✔✔The three Rs of Russell and Burch stand for what? - ✔✔Replacement, reduction,
and refinement
✔✔Which of the following statements about postoperative care records is TRUE? -
✔✔For rodents, postoperative records for the group may be kept on cage cards or in
laboratory notebooks.
✔✔Endpoint criteria describe when it is time to do what? - ✔✔Intervene to remove an
animal from a study, sometimes by euthanizing an animal
✔✔Prior to IACUC review of the animal use protocol application that describes
procedures that are expected to cause more than momentary pain or distress, which of
