1-100 Complete Questions & Answers (Solved)
100% Correct
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40 y/o male presents to ER w fever & malaise. Pt states he has
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not been able to eat anything over the last 24 hrs. On PE, you
note petechiae on the skin & joint pain on movement. You
order a whole bunch of labs & p-ANCA comes back positive.
What is your suspected dx & what would you do to confirm it?
1. microscopic polyangiitis
2. kidney biopsy to confirm
,35 y/o male presents to ER w fever, malaise, & joint pain. Pt
has a PMHx of chronic rhinosinusitis & asthma. On PE, you
note purpura on the skin. You perform a whole bunch of other
tests which leads you to getting a biopsy. Results show
predominant eosinophilia & granulomas. What is your most
likely dx & how would you tx it?
1. eosinophilic granulomatosis w polyangiitis
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2. prednisone
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What are the 2 most commonly affected organs by
eosinophilic granulomatosis w polyangiitis?
N
skin & lungs
O
39 y/o male presents to ER w hematuria. Pt was seen 3
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months ago & had a full renal work up then w insignificant
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results. Today, it is noted that pts GFR has declined by 50% &
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his condition is worsening. You order a renal biopsy & find
crescent formation. What is your most likely dx?
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rapidly progressive glomerulonephritis
*many underlying causes*
Who is goodpasture's syndrome most common in?
young men in late 20s
&
,men & women in 60s-70s
*bimodal distribution*
____________ syndrome is lung hemorrhage +
glomerulonephritis. goodpasture's syndrome
D
At the glomerulus, blood enters via the _____________ &
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exits via the _____________.
afferent arteriole, efferent arteriole
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What is the job of the glomerular basement membrane?
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provide size & charge selective barrier to the passage of
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macromolecules from the plasma
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What is the hallmark of glomerular disorders? proteinuria
O
What are glomerular disorders classified based on? urine
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changes
In ____________ syndromes, there is leakage of plasma
protein into the urine w/out inflammation.
nephrotic
___________ syndrome is associated w proteinuria, while
_________ syndrome is associated w hematuria. nephrotic,
nephritic
, In _________________, inflammation w/in the glomerulus
leads to passage of plasma proteins, inflammatory cells
(leukocytes) & RBCs into the renal tubule. glomerulonephritis
What is the most common type of glomerulonephritis?
IgA glomerulonephritis
What 3 glomerulonephritis occur secondary to immune
complex deposits?
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IgA, post-strep, & lupus nephritis
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True/False
Immune complex deposition occurs when there is
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overproduction of antigen compared to antibody production.
O
true!
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Why does immune complex deposition cause
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glomerulonephritis?
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excess antigen (not enough antibodies to f em up) stays in the
circulation & has the be filtered by the kidney = injured kidney
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What is the most common cause of post strep
glomerulonephritis?
Group A beta-hemolytic strep
True/False
Pauci immune glomerulonephritis causes kidney diseases
w/out direct immune complex deposition or antibody binding.
true