MARYVILLE PHARMACOLOGY EVALUATION EXAM
TEST QUESTIONS AND ANSWERS SURE A+
✔✔What medication is a lipoglycopeptide? - ✔✔Vancomycin
✔✔Is vancomycine bacteriostatic or bacteriocidal? - ✔✔Bacteriocidal
✔✔Why is vancomycin typically given IV? - ✔✔It is too large to pass through cell
membranes of the GI tract so it is not absorbed systemically
✔✔When and why is vancomycin given orally? - ✔✔In C. Diff infection because it works
topically in the gut to kill C. Diff
✔✔What is vancomycin used for? - ✔✔MRSA
✔✔Vancomycin peak and trough levels: for who and why? - ✔✔Vancomycin is excreted
unchanged by the kidneys; caution in elderly and renal insufficiency patients
✔✔What is a serious adverse effect of vancomycin? - ✔✔Red Man Syndrome
✔✔Which antibiotics target DNA replication? - ✔✔Fluoroquinolones and sulfonamides
, ✔✔How would you describe fluoroquinolones? - ✔✔Bacteriocidal and BROAD spectrum
✔✔What are fluoroquinolones used for? - ✔✔Serious infections; hospital or community
acquired infections
✔✔What is the black box warning for fluoroquinolones? - ✔✔Tendonitis and tendon
rupture in all age groups; especially in Achille's tendon
✔✔What medication does fluoroquinolones enhance the effects of? - ✔✔Warfarin;
increases bleeding risk because it interacts with the CYP450 system
✔✔Why are fluoroquinolones avoided in children and pregnancy? - ✔✔They can inhibit
bone growth and they are bad for tendons
✔✔When is the risk for tendon rupture the greatest with use of fluoroquinolones? -
✔✔1. transplant patients
2. recent corticosteroid use
3. advanced age
4. increased quinolone doses
✔✔Are sulfonamides bacteriocidal or bacteriostatic? - ✔✔Bacteriostatic
✔✔If there an an allergy to sulfonamides, which other drugs should be avoided because
they are developed from the sulfonamide drugs? - ✔✔Sulfonylureas, thiazide diuretics,
loop diuretics
✔✔What is sulfasalazine used for? - ✔✔RA, Crohn's, ulcerative colitis, inflammatory
disorders
✔✔When should you avoid Sulfa medications? - ✔✔In patients with G6PD
✔✔What are side effects of sulfonamides? - ✔✔Kernictus (think bilirubin an brain
damage), urinary tract disorders, hematopoietic disorders
✔✔How and when is silver sulfadiazine used? - ✔✔Used for burns, but its usefulness is
poor
✔✔What antibiotics block protein productioN? - ✔✔tetracyclines, macrolides,
aminoglycosides, lincosamides
✔✔Are tetracyclines bacteriostatic or bacteriocidal? - ✔✔bacteriostatic
TEST QUESTIONS AND ANSWERS SURE A+
✔✔What medication is a lipoglycopeptide? - ✔✔Vancomycin
✔✔Is vancomycine bacteriostatic or bacteriocidal? - ✔✔Bacteriocidal
✔✔Why is vancomycin typically given IV? - ✔✔It is too large to pass through cell
membranes of the GI tract so it is not absorbed systemically
✔✔When and why is vancomycin given orally? - ✔✔In C. Diff infection because it works
topically in the gut to kill C. Diff
✔✔What is vancomycin used for? - ✔✔MRSA
✔✔Vancomycin peak and trough levels: for who and why? - ✔✔Vancomycin is excreted
unchanged by the kidneys; caution in elderly and renal insufficiency patients
✔✔What is a serious adverse effect of vancomycin? - ✔✔Red Man Syndrome
✔✔Which antibiotics target DNA replication? - ✔✔Fluoroquinolones and sulfonamides
, ✔✔How would you describe fluoroquinolones? - ✔✔Bacteriocidal and BROAD spectrum
✔✔What are fluoroquinolones used for? - ✔✔Serious infections; hospital or community
acquired infections
✔✔What is the black box warning for fluoroquinolones? - ✔✔Tendonitis and tendon
rupture in all age groups; especially in Achille's tendon
✔✔What medication does fluoroquinolones enhance the effects of? - ✔✔Warfarin;
increases bleeding risk because it interacts with the CYP450 system
✔✔Why are fluoroquinolones avoided in children and pregnancy? - ✔✔They can inhibit
bone growth and they are bad for tendons
✔✔When is the risk for tendon rupture the greatest with use of fluoroquinolones? -
✔✔1. transplant patients
2. recent corticosteroid use
3. advanced age
4. increased quinolone doses
✔✔Are sulfonamides bacteriocidal or bacteriostatic? - ✔✔Bacteriostatic
✔✔If there an an allergy to sulfonamides, which other drugs should be avoided because
they are developed from the sulfonamide drugs? - ✔✔Sulfonylureas, thiazide diuretics,
loop diuretics
✔✔What is sulfasalazine used for? - ✔✔RA, Crohn's, ulcerative colitis, inflammatory
disorders
✔✔When should you avoid Sulfa medications? - ✔✔In patients with G6PD
✔✔What are side effects of sulfonamides? - ✔✔Kernictus (think bilirubin an brain
damage), urinary tract disorders, hematopoietic disorders
✔✔How and when is silver sulfadiazine used? - ✔✔Used for burns, but its usefulness is
poor
✔✔What antibiotics block protein productioN? - ✔✔tetracyclines, macrolides,
aminoglycosides, lincosamides
✔✔Are tetracyclines bacteriostatic or bacteriocidal? - ✔✔bacteriostatic
