Pharmacology Module #1,#2 & #3 EXAM REVIEW,
pharmacology module 3, Adv Pharm 5334 UTA Exam 1#1
Questions with correct answers
What are the four phases of pharmacokinetics? - ✔✔- Absorption, distribution,
metabolism, excretion
Bioavailability - ✔✔The extent of drug that becomes available to the body after
absorption
"Free Drug" - ✔✔- The drug that is not bound to protein that is free to exert a
therapeutic effect
Nicotine is a? What (3) effects does it have? - ✔✔- A CYP 450 inducer
- Increase metabolism of drug and result in decreased effects and shortened half-
life
Grapefruit Juice is a? What (3) effects does it have? - ✔✔- A CYP 450 Inhibitor
- Decreased metabolism
- Drug toxicity
- Shorted half life
Kidneys - ✔✔The main organs responsible for drug excretion
Half-life - ✔✔The time required for one half of the drug to be removed from the
body
,Peak Effect - ✔✔The time taken for the drug to reach maximum therapeutic
response
Peak Level - ✔✔- The highest concentration of drug in blood
Drug Polymorphism - ✔✔The effect of a patient's age, gender, size, body
composition and other characteristics on the pharmacokinetics of a specific drug
Drug Polymorphism can be categorized into what (3) different factors. - ✔✔1.
Environmental (diet & nutritional status)
2. Cultural
3. Genetic factors
How can high-fat diets affect absorption? How can malnutrition affect
absorption? - ✔✔- High Fat Diets = increased absorption of many drugs
- Malnutrition = alter the ability to absorb or eliminate medication
Drugs like Heroin and LSD are considered category ____? - ✔✔- Category I
The normal range for albumin is _____ - _____ grams/dL - ✔✔- 4-6 grams/dl
If the gastric pH level is high, this means the stomach is more _______ than
normal. - ✔✔- Alkaline
,Prodrug - ✔✔- A drug that is converted from an inactive form into an active
metabolite through biotransformation in the liver
Paradoxical Reaction - ✔✔- The opposite reaction than what is expected with the
specific drug
The three names for Medications? - ✔✔- Chemical, trade and generic
Chemical name of a drug refers to? - ✔✔- The chemical structure
Trade name / brand name of a medication - ✔✔- proprietary name
- more expensive than generic
- Shorter, easier name
Generic Medication - ✔✔- Most commonly used
- most prescriptions are
Pharmacokinetics of Oral Medications (4 steps) - ✔✔1. Drug is ingested
2. Disintegrated
3. Forms a dissolution
4. Absorption can occur
What is absorption? - ✔✔- The movement of a drug from its site of administration
into the bloodstream for distributions to tissues
, A drug that is absorbed through the intestines must ______ pass through the
_______ before it reaches the ________ circulation. - ✔✔- A drug that is
absorbed through the intestines must first pass through the liver before it reaches
the systemic circulation
High first-pass effect - ✔✔- A large portion is changed into an inactive metabolite
Which routes of medication administration would be impacted by first pass
effect? - ✔✔- Anything GI related can have first pass effect
- Oral and Rectal administration
Which routes will not be impacted by first-pass effect? - ✔✔- Parenteral and
topical
What are the (3) basic routes of medication administration? - ✔✔- Enteral,
Parenteral, and topical
What is enteral route of medication administration? - ✔✔- Is absorbed through
the GI mucosa
What is parenteral route of medication administration? What does it normally
refer to? - ✔✔- The fastest route
- Any route other than the GI tract
- Normally refers to injection
-
pharmacology module 3, Adv Pharm 5334 UTA Exam 1#1
Questions with correct answers
What are the four phases of pharmacokinetics? - ✔✔- Absorption, distribution,
metabolism, excretion
Bioavailability - ✔✔The extent of drug that becomes available to the body after
absorption
"Free Drug" - ✔✔- The drug that is not bound to protein that is free to exert a
therapeutic effect
Nicotine is a? What (3) effects does it have? - ✔✔- A CYP 450 inducer
- Increase metabolism of drug and result in decreased effects and shortened half-
life
Grapefruit Juice is a? What (3) effects does it have? - ✔✔- A CYP 450 Inhibitor
- Decreased metabolism
- Drug toxicity
- Shorted half life
Kidneys - ✔✔The main organs responsible for drug excretion
Half-life - ✔✔The time required for one half of the drug to be removed from the
body
,Peak Effect - ✔✔The time taken for the drug to reach maximum therapeutic
response
Peak Level - ✔✔- The highest concentration of drug in blood
Drug Polymorphism - ✔✔The effect of a patient's age, gender, size, body
composition and other characteristics on the pharmacokinetics of a specific drug
Drug Polymorphism can be categorized into what (3) different factors. - ✔✔1.
Environmental (diet & nutritional status)
2. Cultural
3. Genetic factors
How can high-fat diets affect absorption? How can malnutrition affect
absorption? - ✔✔- High Fat Diets = increased absorption of many drugs
- Malnutrition = alter the ability to absorb or eliminate medication
Drugs like Heroin and LSD are considered category ____? - ✔✔- Category I
The normal range for albumin is _____ - _____ grams/dL - ✔✔- 4-6 grams/dl
If the gastric pH level is high, this means the stomach is more _______ than
normal. - ✔✔- Alkaline
,Prodrug - ✔✔- A drug that is converted from an inactive form into an active
metabolite through biotransformation in the liver
Paradoxical Reaction - ✔✔- The opposite reaction than what is expected with the
specific drug
The three names for Medications? - ✔✔- Chemical, trade and generic
Chemical name of a drug refers to? - ✔✔- The chemical structure
Trade name / brand name of a medication - ✔✔- proprietary name
- more expensive than generic
- Shorter, easier name
Generic Medication - ✔✔- Most commonly used
- most prescriptions are
Pharmacokinetics of Oral Medications (4 steps) - ✔✔1. Drug is ingested
2. Disintegrated
3. Forms a dissolution
4. Absorption can occur
What is absorption? - ✔✔- The movement of a drug from its site of administration
into the bloodstream for distributions to tissues
, A drug that is absorbed through the intestines must ______ pass through the
_______ before it reaches the ________ circulation. - ✔✔- A drug that is
absorbed through the intestines must first pass through the liver before it reaches
the systemic circulation
High first-pass effect - ✔✔- A large portion is changed into an inactive metabolite
Which routes of medication administration would be impacted by first pass
effect? - ✔✔- Anything GI related can have first pass effect
- Oral and Rectal administration
Which routes will not be impacted by first-pass effect? - ✔✔- Parenteral and
topical
What are the (3) basic routes of medication administration? - ✔✔- Enteral,
Parenteral, and topical
What is enteral route of medication administration? - ✔✔- Is absorbed through
the GI mucosa
What is parenteral route of medication administration? What does it normally
refer to? - ✔✔- The fastest route
- Any route other than the GI tract
- Normally refers to injection
-
