APHON CHEMO STUDY EXAMS GUIDE ALL
QUESTIONS AND ANSWERS SURE A+
✔✔What chemo agents interfere with development of blood vessels? -
✔✔Angiogenesis inhibitors
✔✔What chemo classification provide an anti cancer effect and not clearly understood?
- ✔✔Biological response modifiers
✔✔Which agents are Cell Cycle Specific? - ✔✔Antimetabolites, plant alkaloids, and
misc agents such as asparaginase and dacarbazine.
✔✔Which agents are cell cycle nonspecific? - ✔✔Alkylating agents, nitrosureas,
antitumor antibiotics, hormones, steroids, and misc agents such as procarbazine
✔✔What are common pediatric chemo alkylating agents? - ✔✔Cyclophosphamide,
ifosfamide, temozolomide, dacarbazine, procarbazine, carboplatin, cisplatin
✔✔What are common pediatric chemo plant alkaloids? - ✔✔Vincristine, vinblastine,
etoposide, irinotecan, topotecan, paclitaxel
, ✔✔What are common side effects of plant alkaloids? - ✔✔Peripheral neuropathies,
constipation, N&V, diarrhea, amenorrhea, and infertility
✔✔Which types of agents are associated with secondary malignancies? - ✔✔Alkylating
agents, plant alkaloids
✔✔What are common side effects of alkylating agents? - ✔✔N&V, bone marrow
suppression, reproductive disabilities
✔✔What are common side effects of antitumor antibiotics? - ✔✔Bone marrow
suppression, mucositis, N&V, cardiac toxicity, reproductive disabilities
✔✔Which antitumor antibiotic is cell cycle specific? - ✔✔Bleomycin-it works in both G2
and M phase
✔✔What are the major side effects of antimetabolites? - ✔✔Bone marrow suppression,
N&V, mucositis, liver injury
✔✔What pediatric chemo drugs are antimetabolite agents? - ✔✔Methotrexate,
fluorouracil (5-FU), cytarabine (Ara-C),
Mercaptopurine (6-MP), thioguanine (6-TG), hydroxyurea
✔✔Which antimetabolite is associated with hepatoportal sclerosis and esophageal
varices? - ✔✔Thioguanine
✔✔Which chemotherapy agents are hormonal agents? - ✔✔Corticosteroids
✔✔How do corticosteroids fight cancers? - ✔✔By lysing lymphoblasts, decreasing
cerebral edema associated with brain tumors, and help with antiemetic control
✔✔What are side effects of corticosteroids? - ✔✔Increased appetite, redistribution of
body fat, hyperglycemia, acne, striae, behavior changes, avascular necrosis.
✔✔Is asparaginase cell cycle specific or nonspecific? - ✔✔Nonspecific
✔✔What class of drug are interferons? - ✔✔Biotherapy or biological response modifiers
(BRM)
✔✔ Biotherapy - ✔✔Targeted anticancer agents also known as biological response
modifiers (BRM)
✔✔Tyrosine kinase inhibitors (TKIs) are what class - ✔✔Biotherapy
✔✔Monoclonal antibodies (MoAbs) are what class - ✔✔Biotherapy
QUESTIONS AND ANSWERS SURE A+
✔✔What chemo agents interfere with development of blood vessels? -
✔✔Angiogenesis inhibitors
✔✔What chemo classification provide an anti cancer effect and not clearly understood?
- ✔✔Biological response modifiers
✔✔Which agents are Cell Cycle Specific? - ✔✔Antimetabolites, plant alkaloids, and
misc agents such as asparaginase and dacarbazine.
✔✔Which agents are cell cycle nonspecific? - ✔✔Alkylating agents, nitrosureas,
antitumor antibiotics, hormones, steroids, and misc agents such as procarbazine
✔✔What are common pediatric chemo alkylating agents? - ✔✔Cyclophosphamide,
ifosfamide, temozolomide, dacarbazine, procarbazine, carboplatin, cisplatin
✔✔What are common pediatric chemo plant alkaloids? - ✔✔Vincristine, vinblastine,
etoposide, irinotecan, topotecan, paclitaxel
, ✔✔What are common side effects of plant alkaloids? - ✔✔Peripheral neuropathies,
constipation, N&V, diarrhea, amenorrhea, and infertility
✔✔Which types of agents are associated with secondary malignancies? - ✔✔Alkylating
agents, plant alkaloids
✔✔What are common side effects of alkylating agents? - ✔✔N&V, bone marrow
suppression, reproductive disabilities
✔✔What are common side effects of antitumor antibiotics? - ✔✔Bone marrow
suppression, mucositis, N&V, cardiac toxicity, reproductive disabilities
✔✔Which antitumor antibiotic is cell cycle specific? - ✔✔Bleomycin-it works in both G2
and M phase
✔✔What are the major side effects of antimetabolites? - ✔✔Bone marrow suppression,
N&V, mucositis, liver injury
✔✔What pediatric chemo drugs are antimetabolite agents? - ✔✔Methotrexate,
fluorouracil (5-FU), cytarabine (Ara-C),
Mercaptopurine (6-MP), thioguanine (6-TG), hydroxyurea
✔✔Which antimetabolite is associated with hepatoportal sclerosis and esophageal
varices? - ✔✔Thioguanine
✔✔Which chemotherapy agents are hormonal agents? - ✔✔Corticosteroids
✔✔How do corticosteroids fight cancers? - ✔✔By lysing lymphoblasts, decreasing
cerebral edema associated with brain tumors, and help with antiemetic control
✔✔What are side effects of corticosteroids? - ✔✔Increased appetite, redistribution of
body fat, hyperglycemia, acne, striae, behavior changes, avascular necrosis.
✔✔Is asparaginase cell cycle specific or nonspecific? - ✔✔Nonspecific
✔✔What class of drug are interferons? - ✔✔Biotherapy or biological response modifiers
(BRM)
✔✔ Biotherapy - ✔✔Targeted anticancer agents also known as biological response
modifiers (BRM)
✔✔Tyrosine kinase inhibitors (TKIs) are what class - ✔✔Biotherapy
✔✔Monoclonal antibodies (MoAbs) are what class - ✔✔Biotherapy
