1
NURS 572 EXAM 1 QUESTIONS WITH
VERIFIED SOLUTIONS
Affinity - correct-answer - The strength of attraction between a drug and its
receptor, drugs with high affinity are strongly attracted to their receptor, drugs
with low affinity are weakly contracted. This affinity is reflected in its potency,
high affinity is very potent
Plateau or steady state - correct-answer - When the amount of drug eliminated
between doses equals the dose administered, average drug levels will remain
constant and plateau will have been reached.
Repeated doses of equal size cause the drug to increase in body until plateau or
steady-state is obtained; plateau is reached in 4 half lives
First-pass effect - correct-answer - rapid inactivation of certain oral drugs by the
liver; if the liver can metabolize the drug quickly it is rendered inactive with no
effect
therapeutic objective of drug therapy - correct-answer - to provide maximum
benefit with minimum harm
, 2
drug absorption - correct-answer - movement of a drug from its site of
administration into the blood
Rate is influenced by chemical and physical properties and rate of dissolution,
surface area, blood flow, lipid solubility, and pH partitioning
drug distribution - correct-answer - movement of drugs from blood to interstitial
space in tissue and onto the cells; determined by blood flow to tissues; ability to
exit vascular systems, ability to enter cells; blood flow determines rate of
distribution
drug metabolism - correct-answer - chemical or enzymatic alteration of drug
structure
drug excretion - correct-answer - Removal of drugs from the body via urine, saliva,
sweat, saliva, breast milk, expired air
kidney is most important organ for excretion
Loading dose - correct-answer - for drugs with large half-lifes and when plateau
must be achieved more quickly a large initial dose may be administered
Maintenance doses - correct-answer - when plateau is achieved and needs to be
maintained with smaller doses
Category A drugs - correct-answer - Remote Risk of Fetal Harm:
NURS 572 EXAM 1 QUESTIONS WITH
VERIFIED SOLUTIONS
Affinity - correct-answer - The strength of attraction between a drug and its
receptor, drugs with high affinity are strongly attracted to their receptor, drugs
with low affinity are weakly contracted. This affinity is reflected in its potency,
high affinity is very potent
Plateau or steady state - correct-answer - When the amount of drug eliminated
between doses equals the dose administered, average drug levels will remain
constant and plateau will have been reached.
Repeated doses of equal size cause the drug to increase in body until plateau or
steady-state is obtained; plateau is reached in 4 half lives
First-pass effect - correct-answer - rapid inactivation of certain oral drugs by the
liver; if the liver can metabolize the drug quickly it is rendered inactive with no
effect
therapeutic objective of drug therapy - correct-answer - to provide maximum
benefit with minimum harm
, 2
drug absorption - correct-answer - movement of a drug from its site of
administration into the blood
Rate is influenced by chemical and physical properties and rate of dissolution,
surface area, blood flow, lipid solubility, and pH partitioning
drug distribution - correct-answer - movement of drugs from blood to interstitial
space in tissue and onto the cells; determined by blood flow to tissues; ability to
exit vascular systems, ability to enter cells; blood flow determines rate of
distribution
drug metabolism - correct-answer - chemical or enzymatic alteration of drug
structure
drug excretion - correct-answer - Removal of drugs from the body via urine, saliva,
sweat, saliva, breast milk, expired air
kidney is most important organ for excretion
Loading dose - correct-answer - for drugs with large half-lifes and when plateau
must be achieved more quickly a large initial dose may be administered
Maintenance doses - correct-answer - when plateau is achieved and needs to be
maintained with smaller doses
Category A drugs - correct-answer - Remote Risk of Fetal Harm:
