UTA MICROBIOLOGY 2460 CORRECT EXAMS
SCRIPT QUESTIONS AND ANSWERS SURE A+
✔✔What do Oxazolidinones do? - ✔✔inhibit protein synthesis of 50S subunit
interferes with connection to 30S subunit
Linezolid
bacteriostatic
broad spectrum
✔✔What do Chloramphenicols do? - ✔✔inhibit protein synthesis of 50S subunit
blocks peptide bond formation b/t AA
bacteriostatic
broad spectrum
rarely used now b/c of serious side effects
✔✔What do Lincosamides do? - ✔✔inhibit protein synthesis of 50S subunit
blocks peptide bond formation b/t AA
bacteriostatic
narrow spectrum Streptococcal, Staphylococcal
✔✔What do Macrolides do? - ✔✔inhibit protein synthesis of 50S subunit
blocks peptide bond formation b/t AA
Erythromycin, Azithromycin
, bacteriostatic
broad spectrum
✔✔What do Tetracyclines do? - ✔✔inhibit protein synthesis of 30S subunit
blocks the binding of tRNAs with ribosome
bacteriostatic
broad spectrum
✔✔What do Aminoglycosides do? - ✔✔inhibit protein synthesis of 30S subunit
impairs proofreading ability
Streptomycin, Gentamicin, Neomycin
bactericidal
broad spectrum
✔✔what do Daptomycins do? - ✔✔inhibit membrane function
cyclic Lipopeptide (drug class)
narrow spectrum G+
✔✔What do Polymyxins do? - ✔✔inhibit membrane function
LPS in G- outer membrane
narrow spectrum G-
also targets host membrane so not selective toxicity
✔✔What does Metronidazole do? - ✔✔inhibit nucleic acid synthesis
DNA replication
bactericidal
broad spectrum
Antiprotozoan
Giardia, Dysentery, Trichomoniasis
✔✔What does Rifampin do? - ✔✔inhibit nucleic acid synthesis
RNA polymerase
bactericidal
narrow spectrum M. tuberculosis
can be antagonistic and hepatotoxic
✔✔What do Fluoroquinolones do? - ✔✔inhibit nucleic acid synthesis
DNA gyrase
bactericidal
broad spectrum G+ and G-
many side effects
✔✔What do Sulfonamides do? - ✔✔inhibit folic acid synthesis
bacteriostatic alone
broad spectrum
SCRIPT QUESTIONS AND ANSWERS SURE A+
✔✔What do Oxazolidinones do? - ✔✔inhibit protein synthesis of 50S subunit
interferes with connection to 30S subunit
Linezolid
bacteriostatic
broad spectrum
✔✔What do Chloramphenicols do? - ✔✔inhibit protein synthesis of 50S subunit
blocks peptide bond formation b/t AA
bacteriostatic
broad spectrum
rarely used now b/c of serious side effects
✔✔What do Lincosamides do? - ✔✔inhibit protein synthesis of 50S subunit
blocks peptide bond formation b/t AA
bacteriostatic
narrow spectrum Streptococcal, Staphylococcal
✔✔What do Macrolides do? - ✔✔inhibit protein synthesis of 50S subunit
blocks peptide bond formation b/t AA
Erythromycin, Azithromycin
, bacteriostatic
broad spectrum
✔✔What do Tetracyclines do? - ✔✔inhibit protein synthesis of 30S subunit
blocks the binding of tRNAs with ribosome
bacteriostatic
broad spectrum
✔✔What do Aminoglycosides do? - ✔✔inhibit protein synthesis of 30S subunit
impairs proofreading ability
Streptomycin, Gentamicin, Neomycin
bactericidal
broad spectrum
✔✔what do Daptomycins do? - ✔✔inhibit membrane function
cyclic Lipopeptide (drug class)
narrow spectrum G+
✔✔What do Polymyxins do? - ✔✔inhibit membrane function
LPS in G- outer membrane
narrow spectrum G-
also targets host membrane so not selective toxicity
✔✔What does Metronidazole do? - ✔✔inhibit nucleic acid synthesis
DNA replication
bactericidal
broad spectrum
Antiprotozoan
Giardia, Dysentery, Trichomoniasis
✔✔What does Rifampin do? - ✔✔inhibit nucleic acid synthesis
RNA polymerase
bactericidal
narrow spectrum M. tuberculosis
can be antagonistic and hepatotoxic
✔✔What do Fluoroquinolones do? - ✔✔inhibit nucleic acid synthesis
DNA gyrase
bactericidal
broad spectrum G+ and G-
many side effects
✔✔What do Sulfonamides do? - ✔✔inhibit folic acid synthesis
bacteriostatic alone
broad spectrum