BIOS390 – Molecular Diagnostics

BIOS390 – Molecular Diagnostics Week 1 (TCO 1) The basic principles of genetics contributed by Gregor Johann Mendel are: 1. The principle of segregation 2. The principle of independent assortment (TCO 1) The Augustinian monk, Gregor Johann Mendel, crossed yellow-seeded and green-seeded pea plants and then allowed the offspring to self-pollinate to produce an F2 generation. The results were as follows: 6018 yellow and 2002 green (8020 total). The allele for green seeds has what relationship to the allele for yellow seeds? • Yellow is dominant over the green seeds, where as green seeds is recessive. (TCO 1) In 1953, James Watson and Francis Crick proposed • The double helix as a model for the structure of DNA. Question Set 2 (TCO 1) In 1928, Frederick Griffith discovered that Streptococcus pneumonia caused pneumonia in mice. In his experiments, mice were injected with different strains of treated and untreated bacteria. Which of the following is not likely to have occurred in the series of experiments by Griffith? • Live S bacteria inject into mice -die • Live R bacteria inject into mice-Live (do not have the capsule) • Heat killed S bacteria inject into mice-live • Mixture of live R bacteria and heat killed S bacteria injected into mice-Die (TCO 1) In 1928, Frederick Griffith injected living S (smooth) Streptococcus pneumonia into mice, and the mice died. When he injected living R (rough) Streptococcus pneumonia into mice, the mice lived. When he injected heat-killed S bacteria into mice, the mice lived. What was the result when he mixed heat-killed S bacteria with live R bacteria and injected this mixture into mice? • Mixture of live R bacteria and heat killed S bacteria injected into mice – The mice Die.