Dosage Calculation Practice
Exam||PHARMACOTHERAPEUTICS FOR
ADVANCED PRACTICE NURSE
PRESCRIBERS, 6TH EDITION
EXAM||(Pharmacotherapeutics
for Advanced Practice Nurses
Test Bank)C0mprehensive Question
Exam Guide 2026 Update
A patient has an order for Chloromycetin, 500 mg every 6 hours. The drug comes in 250
mg capsules. What would the nurse administer? - ANSWER-2 tabs
A nurse is to administer 150 mg of a drug intramuscularly. The label on the multidose
vials reads 100 mg/mL. How much would the nurse give? - ANSWER-1.5 mL
A nurse is to administer 30 mg of furosemide (Lasix) to a client with congestive heart
failure (CHF). The vial contains 40 mg/mL. Which is the correct dose to administer? -
ANSWER-0.75 mL
The nurse is providing discharge teaching for a client who has been prescribed 600 mg
of an oral liquid medication. The mother shows the nurse the label of the medication,
which reads: 250 mg/mL. The nurse would instruct the mother to give how many
milliliters? - ANSWER-2.4 mL
A child is to receive 500 mg of an antibiotic suspension. The label on the bottle reads
250 mg/5 mL. The nurse should administer how much of the suspension in one dose? -
ANSWER-10 mL
A health care provider orders 250 mg of an antibiotic suspension. The label on the
suspension reads "500 mg/5 mL." How much would the nurse administer? - ANSWER-
2.5 mL
The client is to be given ascorbic acid 1 g daily by mouth. The medication comes in a
container labeled, "Ascorbic Acid 250 mg tablets." How much will the nurse give? -
ANSWER-4 tabs
,The PCP orders amoxicillin 250 mg by mouth two times a day. The drug label reads
"Amoxicillin 125 mg/5 ml." How much will the nurse administer? - ANSWER-10 mL
A nurse is to administer 175 mg of a medication intramuscularly. The label on the
multidose vial states that the concentration is 100 mg/mL. What volume of the drug
should the nurse administer? - ANSWER-1.7 mL
The nurse is preparing to administer 80 mg of Solu-medrol intravenously (IV) to a client
with pneumonia. The vial states that it has 120 mg per 2 mL. The nurse would correctly
draw up which amount? - ANSWER-1.3 mL
The health care provider prescribes ascorbic acid 0.5 g daily. The drug label reads
ascorbic acid 250 mg. The nurse would administer how many tablets? - ANSWER-2
tabs
A client is being treated for congestive heart failure (CHF) and is to receive 0.5
milligrams of digoxin, which is available in 250-microgram tablets. The nurse would
correctly administer how many tablets? - ANSWER-2 tabs
The nurse is to administer 25 mg of meperidine (Demerol). The vial states that it
contains meperidine 50mg/1 mL. How much medication should the nurse draw up for
the ordered dosage? - ANSWER-0.5 mL
A nurse needs to convert 3 fluid ounces to the metric system equivalent. The nurse
performs the calculation to find which result? - ANSWER-90 mL
A client has been prescribed a one-time dose of 4 mg morphine IV. The medication is
available in ampules of 10 mg/mL. What volume of morphine should the nurse draw up?
- ANSWER-0.4 mL
A physical orders 75 mcg of a drug IM daily. The drug is available in a vial labeled 0.5
mg in 5 mL. How many mL with the patient receive? - ANSWER-0.75 mL
The patient is to receive 750 mg of a drug PO daily. The drug bottle is labeled 0.5 g in 5
mL. How many Tbs will the patient receive? - ANSWER-0.5 Tbs
The order is for 1 g of a medication PO BID. The pharmacy sends the medication
labeled 200 mg in 5 mL. How many mL should the nurse administer? - ANSWER-25 mL
The physician orders to administer Prednisolone oral solution 0.03 g daily. The label
reads Predisolone 15 mg per 5 mL. How many tsp will the patient receive? - ANSWER-
2 tsp
,The physician orders granisetron 450 mcg IV 30 minutes prior to chemotherapy. The
label reads 0.1 mg per mL. How many mL will the nurse administer to the patient? -
ANSWER-4.5 mL
Nurse practitioner prescriptive authority is regulated by who? - ANSWER-The State
Board of Nursing for Each State
What is the benefits of having an APRN prescriber? - ANSWER-APRN's care for
patients more holistically and include patients in making decisions regarding their care
What does clinical judgement in prescribing include? - ANSWER-Factoring in the cost of
the particular
What is included in the criteria for choosing and effective drug for a disorder? -
ANSWER-Consulting nationally recognized guidelines for disease management
NP's thrive under the new health-care reform because of what? - ANSWER-NP's have
the ability to control care cost and improve patient outcome
Nutritional intake and lab results reflect hypoalbuminemia; why is this important for
prescribers? - ANSWER-The Distribution of drugs to target tissues may be affected
Drugs that have an significant first-pass effect what? - ANSWER-they are rapidly
metabolized by the liver and may have little if any desired action
The route of excretion of a volatile drug will likely be? - ANSWER-Lungs
Medroxyprogesterone (Depo Provera) is prescribed IM to create storage reservoir of the
drug. What are storage reserviors> - ANSWER-Increased the length of time a drug is
available and active
Why is Cephalexin given every 8 hours? What knowledge of the drug does the NP
know? - ANSWER-Half Life
Azithromycin doing requires that the first day's doing be twice those of the other four
day; This is considered a loading does. What is a loading dose? - ANSWER-Rapidly
actives drug levels in the therapeutic range
The point in time on the drug concentration curve that indicates the first sign of a
therapeutic effect is the: - ANSWER-Onset of action
Phenytoin required that a trough level be drawn. When and why are peak and trough
levels are done - ANSWER-To determine if a d rug is in the therapeutic range
Drugs that are receptor agonists may demonstrate what property? - ANSWER-
Concentrations will produce an adverse effect
, Factors that affect gastric drug absorption include - ANSWER-Lipid solubility of the drug
Drugs that are receptors antagonists, such as beta-blockers, may cause what? -
ANSWER-An exaggerated response if abrupt discontinues
Drug administration via IV:
1) need to be lipid soluble in order to absorb easily
2) Begin distribution in the body immediately
3) Are easily absorbed if they are nonionized
4) May use pinocytosis to be absorbed - ANSWER-Are easily absorbed if they are
nonionized
What is the combination effect when a medication is added to a regimen for a
synergistic effect? - ANSWER-Greater than the sum of the effects of each drug
individually
Which of the following statements about bioavailability is true?
1) Bioavailability issues are especially important for drugs with narrow therapeutic
ranges or sustained-release mechanisms.
2) brands of a drug have the same bioavailability.
3) Drugs that are administered more than once a day have greater bioavailability than
drugs given once daily.
4) Combining an active drug with an inert substance does not affect bioavailability. -
ANSWER-Bioavailability issues are especially important for drugs with narrow
therapeutic
Which of the following statements about the major distribution barriers (blood-brain or
fetal-placental) is true?
1) Water soluble and ionized drugs cross these barriers rapidly.
2) The blood-brain barrier slows the entry of many drugs into and from brain cells.
3) The fetal-placental barrier protects the fetus from drugs taken by the mother.
4) Lipid-soluble drugs do not pass these barriers and are safe for pregnant women -
ANSWER-The blood-brain barrier slows the entry of many drugs into and from brain
cells.
What is the purpose of phase I and phase II of metabolism in the liver? - ANSWER-
Change drug molecules to a form that an excretory organ can excrete
What happens to the metabolites after they are metabolized in the liver? - ANSWER-the
metabolite may or may not be more active than the parent drug and they are totally
deactivated so they are excreted without and effect; it depends on the medication being
given
What causes the body to increased the excretion of a drug through the renal system -
ANSWER-Unbinding a nonvolatile drug from plasma proteins.
Exam||PHARMACOTHERAPEUTICS FOR
ADVANCED PRACTICE NURSE
PRESCRIBERS, 6TH EDITION
EXAM||(Pharmacotherapeutics
for Advanced Practice Nurses
Test Bank)C0mprehensive Question
Exam Guide 2026 Update
A patient has an order for Chloromycetin, 500 mg every 6 hours. The drug comes in 250
mg capsules. What would the nurse administer? - ANSWER-2 tabs
A nurse is to administer 150 mg of a drug intramuscularly. The label on the multidose
vials reads 100 mg/mL. How much would the nurse give? - ANSWER-1.5 mL
A nurse is to administer 30 mg of furosemide (Lasix) to a client with congestive heart
failure (CHF). The vial contains 40 mg/mL. Which is the correct dose to administer? -
ANSWER-0.75 mL
The nurse is providing discharge teaching for a client who has been prescribed 600 mg
of an oral liquid medication. The mother shows the nurse the label of the medication,
which reads: 250 mg/mL. The nurse would instruct the mother to give how many
milliliters? - ANSWER-2.4 mL
A child is to receive 500 mg of an antibiotic suspension. The label on the bottle reads
250 mg/5 mL. The nurse should administer how much of the suspension in one dose? -
ANSWER-10 mL
A health care provider orders 250 mg of an antibiotic suspension. The label on the
suspension reads "500 mg/5 mL." How much would the nurse administer? - ANSWER-
2.5 mL
The client is to be given ascorbic acid 1 g daily by mouth. The medication comes in a
container labeled, "Ascorbic Acid 250 mg tablets." How much will the nurse give? -
ANSWER-4 tabs
,The PCP orders amoxicillin 250 mg by mouth two times a day. The drug label reads
"Amoxicillin 125 mg/5 ml." How much will the nurse administer? - ANSWER-10 mL
A nurse is to administer 175 mg of a medication intramuscularly. The label on the
multidose vial states that the concentration is 100 mg/mL. What volume of the drug
should the nurse administer? - ANSWER-1.7 mL
The nurse is preparing to administer 80 mg of Solu-medrol intravenously (IV) to a client
with pneumonia. The vial states that it has 120 mg per 2 mL. The nurse would correctly
draw up which amount? - ANSWER-1.3 mL
The health care provider prescribes ascorbic acid 0.5 g daily. The drug label reads
ascorbic acid 250 mg. The nurse would administer how many tablets? - ANSWER-2
tabs
A client is being treated for congestive heart failure (CHF) and is to receive 0.5
milligrams of digoxin, which is available in 250-microgram tablets. The nurse would
correctly administer how many tablets? - ANSWER-2 tabs
The nurse is to administer 25 mg of meperidine (Demerol). The vial states that it
contains meperidine 50mg/1 mL. How much medication should the nurse draw up for
the ordered dosage? - ANSWER-0.5 mL
A nurse needs to convert 3 fluid ounces to the metric system equivalent. The nurse
performs the calculation to find which result? - ANSWER-90 mL
A client has been prescribed a one-time dose of 4 mg morphine IV. The medication is
available in ampules of 10 mg/mL. What volume of morphine should the nurse draw up?
- ANSWER-0.4 mL
A physical orders 75 mcg of a drug IM daily. The drug is available in a vial labeled 0.5
mg in 5 mL. How many mL with the patient receive? - ANSWER-0.75 mL
The patient is to receive 750 mg of a drug PO daily. The drug bottle is labeled 0.5 g in 5
mL. How many Tbs will the patient receive? - ANSWER-0.5 Tbs
The order is for 1 g of a medication PO BID. The pharmacy sends the medication
labeled 200 mg in 5 mL. How many mL should the nurse administer? - ANSWER-25 mL
The physician orders to administer Prednisolone oral solution 0.03 g daily. The label
reads Predisolone 15 mg per 5 mL. How many tsp will the patient receive? - ANSWER-
2 tsp
,The physician orders granisetron 450 mcg IV 30 minutes prior to chemotherapy. The
label reads 0.1 mg per mL. How many mL will the nurse administer to the patient? -
ANSWER-4.5 mL
Nurse practitioner prescriptive authority is regulated by who? - ANSWER-The State
Board of Nursing for Each State
What is the benefits of having an APRN prescriber? - ANSWER-APRN's care for
patients more holistically and include patients in making decisions regarding their care
What does clinical judgement in prescribing include? - ANSWER-Factoring in the cost of
the particular
What is included in the criteria for choosing and effective drug for a disorder? -
ANSWER-Consulting nationally recognized guidelines for disease management
NP's thrive under the new health-care reform because of what? - ANSWER-NP's have
the ability to control care cost and improve patient outcome
Nutritional intake and lab results reflect hypoalbuminemia; why is this important for
prescribers? - ANSWER-The Distribution of drugs to target tissues may be affected
Drugs that have an significant first-pass effect what? - ANSWER-they are rapidly
metabolized by the liver and may have little if any desired action
The route of excretion of a volatile drug will likely be? - ANSWER-Lungs
Medroxyprogesterone (Depo Provera) is prescribed IM to create storage reservoir of the
drug. What are storage reserviors> - ANSWER-Increased the length of time a drug is
available and active
Why is Cephalexin given every 8 hours? What knowledge of the drug does the NP
know? - ANSWER-Half Life
Azithromycin doing requires that the first day's doing be twice those of the other four
day; This is considered a loading does. What is a loading dose? - ANSWER-Rapidly
actives drug levels in the therapeutic range
The point in time on the drug concentration curve that indicates the first sign of a
therapeutic effect is the: - ANSWER-Onset of action
Phenytoin required that a trough level be drawn. When and why are peak and trough
levels are done - ANSWER-To determine if a d rug is in the therapeutic range
Drugs that are receptor agonists may demonstrate what property? - ANSWER-
Concentrations will produce an adverse effect
, Factors that affect gastric drug absorption include - ANSWER-Lipid solubility of the drug
Drugs that are receptors antagonists, such as beta-blockers, may cause what? -
ANSWER-An exaggerated response if abrupt discontinues
Drug administration via IV:
1) need to be lipid soluble in order to absorb easily
2) Begin distribution in the body immediately
3) Are easily absorbed if they are nonionized
4) May use pinocytosis to be absorbed - ANSWER-Are easily absorbed if they are
nonionized
What is the combination effect when a medication is added to a regimen for a
synergistic effect? - ANSWER-Greater than the sum of the effects of each drug
individually
Which of the following statements about bioavailability is true?
1) Bioavailability issues are especially important for drugs with narrow therapeutic
ranges or sustained-release mechanisms.
2) brands of a drug have the same bioavailability.
3) Drugs that are administered more than once a day have greater bioavailability than
drugs given once daily.
4) Combining an active drug with an inert substance does not affect bioavailability. -
ANSWER-Bioavailability issues are especially important for drugs with narrow
therapeutic
Which of the following statements about the major distribution barriers (blood-brain or
fetal-placental) is true?
1) Water soluble and ionized drugs cross these barriers rapidly.
2) The blood-brain barrier slows the entry of many drugs into and from brain cells.
3) The fetal-placental barrier protects the fetus from drugs taken by the mother.
4) Lipid-soluble drugs do not pass these barriers and are safe for pregnant women -
ANSWER-The blood-brain barrier slows the entry of many drugs into and from brain
cells.
What is the purpose of phase I and phase II of metabolism in the liver? - ANSWER-
Change drug molecules to a form that an excretory organ can excrete
What happens to the metabolites after they are metabolized in the liver? - ANSWER-the
metabolite may or may not be more active than the parent drug and they are totally
deactivated so they are excreted without and effect; it depends on the medication being
given
What causes the body to increased the excretion of a drug through the renal system -
ANSWER-Unbinding a nonvolatile drug from plasma proteins.
