NU 327 Pathophysiology Exam 1 with
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answers
Chronic Myeloid Leukemias (CML) - CORRECT ANSWERS
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✔✔Overproduction of Granulocytes carrying the Philadelphia |\ |\ |\ |\ |\ |\
chromosome. |\
Onset is 40-50 years old, survival rate about 2 years after
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diagnosis. LA- 50% survival |\ |\ |\
Acute Myeloid Leukemia (AML) - CORRECT ANSWERS ✔✔80% of
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all adult leukemia, frequent infections esp. skin, GI, GU, & resp.
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tract.
LA 40-50% for children
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LA 20-30% in adults
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Chronic Lymphoid Leukemias (CLL) - CORRECT ANSWERS
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✔✔Usually due to malignant b-cell precursor that invades
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lymphoid tissue & bone marrow ⇒ prolonged apoptosis
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Usually die with disease. Onset 60-70 years old
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,Acute Lymphoblastic Leukemias / Lymphomas - CORRECT
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ANSWERS ✔✔Majority are malignant lymphoblastic leukemia
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Common in children (Best survival rate)
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LA 85% kids and 30-50% adults
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Acute Lymphoblastic Leukemias / Lymphomas - CORRECT
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ANSWERS ✔✔Bone pain, bruising, fever, abdominal pain, activity
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avoidance.
Plasma Cell Myeloma (Multiple Myeloma) - CORRECT ANSWERS
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✔✔Malignancy of b-cells ⇒ increase in antibody fragments called
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Bence Jones proteins
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Multiple Tumor sites: bone, liver, spleen, kidneys, lymph nodes
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Slow onset
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Higher incidence in males
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Onset starts at 40 years
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Plasma Cell Myeloma (Multiple Myeloma) - CORRECT ANSWERS
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✔✔Most (insidious onset) are associated w/deposition of the
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antibody fragments in the bone and kidneys.
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High Ca++ in blood & urine, renal failure (calcium deposits in
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kidneys), honeycomb bone, bone pain, fractures
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, Hodgkin's Disease - CORRECT ANSWERS ✔✔Malignancies of
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lymph nodes that produce Reed Sternberg cells from b-cells in
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association w/ |\ |\
90% survival at 10 years.
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Most common in males
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Onset between 20-40 years
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Hodgkin's Disease - CORRECT ANSWERS ✔✔Epstein-Barr Virus.
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Predictable metastatic pattern |\ |\ |\
Slow progress
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Non-Hodgkin's Disease - CORRECT ANSWERS ✔✔Malignancies
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arising in lymph nodes that originate in ANY lymph tissue and DO
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NOT have the Redd Sternberg cells.
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Survival 50% at 5 years
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Non-Hodgkin's Disease - CORRECT ANSWERS ✔✔Unpredictable
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paths. |\
Thought to be associated w/ Burkett's lymphoma & Epstein Barr)
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answers
Chronic Myeloid Leukemias (CML) - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\
✔✔Overproduction of Granulocytes carrying the Philadelphia |\ |\ |\ |\ |\ |\
chromosome. |\
Onset is 40-50 years old, survival rate about 2 years after
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
diagnosis. LA- 50% survival |\ |\ |\
Acute Myeloid Leukemia (AML) - CORRECT ANSWERS ✔✔80% of
|\ |\ |\ |\ |\ |\ |\ |\ |\
all adult leukemia, frequent infections esp. skin, GI, GU, & resp.
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
tract.
LA 40-50% for children
|\ |\ |\
LA 20-30% in adults
|\ |\ |\
Chronic Lymphoid Leukemias (CLL) - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\
✔✔Usually due to malignant b-cell precursor that invades
|\ |\ |\ |\ |\ |\ |\ |\
lymphoid tissue & bone marrow ⇒ prolonged apoptosis
|\ |\ |\ |\ |\ |\ |\ |\
Usually die with disease. Onset 60-70 years old
|\ |\ |\ |\ |\ |\ |\
,Acute Lymphoblastic Leukemias / Lymphomas - CORRECT
|\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔Majority are malignant lymphoblastic leukemia
|\ |\ |\ |\ |\
Common in children (Best survival rate)
|\ |\ |\ |\ |\
LA 85% kids and 30-50% adults
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Acute Lymphoblastic Leukemias / Lymphomas - CORRECT
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ANSWERS ✔✔Bone pain, bruising, fever, abdominal pain, activity
|\ |\ |\ |\ |\ |\ |\ |\
avoidance.
Plasma Cell Myeloma (Multiple Myeloma) - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\
✔✔Malignancy of b-cells ⇒ increase in antibody fragments called
|\ |\ |\ |\ |\ |\ |\ |\ |\
Bence Jones proteins
|\ |\ |\
Multiple Tumor sites: bone, liver, spleen, kidneys, lymph nodes
|\ |\ |\ |\ |\ |\ |\ |\
Slow onset
|\ |\
Higher incidence in males
|\ |\ |\ |\
Onset starts at 40 years
|\ |\ |\ |\
Plasma Cell Myeloma (Multiple Myeloma) - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\
✔✔Most (insidious onset) are associated w/deposition of the
|\ |\ |\ |\ |\ |\ |\ |\
antibody fragments in the bone and kidneys.
|\ |\ |\ |\ |\ |\ |\
High Ca++ in blood & urine, renal failure (calcium deposits in
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
kidneys), honeycomb bone, bone pain, fractures
|\ |\ |\ |\ |\
, Hodgkin's Disease - CORRECT ANSWERS ✔✔Malignancies of
|\ |\ |\ |\ |\ |\ |\
lymph nodes that produce Reed Sternberg cells from b-cells in
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
association w/ |\ |\
90% survival at 10 years.
|\ |\ |\ |\ |\
Most common in males
|\ |\ |\
Onset between 20-40 years
|\ |\ |\
Hodgkin's Disease - CORRECT ANSWERS ✔✔Epstein-Barr Virus.
|\ |\ |\ |\ |\ |\
Predictable metastatic pattern |\ |\ |\
Slow progress
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Non-Hodgkin's Disease - CORRECT ANSWERS ✔✔Malignancies
|\ |\ |\ |\ |\ |\
arising in lymph nodes that originate in ANY lymph tissue and DO
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
NOT have the Redd Sternberg cells.
|\ |\ |\ |\ |\ |\ |\
Survival 50% at 5 years
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Non-Hodgkin's Disease - CORRECT ANSWERS ✔✔Unpredictable
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paths. |\
Thought to be associated w/ Burkett's lymphoma & Epstein Barr)
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