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Psychiatry Boards Study Guide Questions and Verified Answers with Rationales (2026–2027) | Latest Psychiatry Board Exam Prep | Grade A+

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Prepare for your Psychiatry Board examinations with this comprehensive Study Guide featuring Questions and Verified Answers with Rationales. This resource includes realistic multiple-choice practice questions covering essential psychiatry topics, including psychiatric assessment, mental status examination, neuroscience, psychopathology, psychopharmacology, psychotherapy, mood disorders, anxiety disorders, schizophrenia spectrum disorders, personality disorders, substance use disorders, child and adolescent psychiatry, geriatric psychiatry, consultation-liaison psychiatry, forensic psychiatry, emergency psychiatry, sleep medicine, ethics, and evidence-based clinical practice. Ideal for psychiatrists, psychiatry residents, fellows, PMHNP students, medical students, and other behavioral health professionals, this study guide helps reinforce key concepts, strengthen diagnostic reasoning, improve exam readiness, and build confidence for board certification and professional practice.

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Psychiatry Boards Study
Guide

Questions with 100% Correct Answers
and Rationales | Latest Update | Grade
A+ | 2026/2027

,What Z drug is less likely to cause drowsiness the next Zaleplon
day?



Antipsychotic of choice in pregnancy Olanzapine




Babies exposed to in utero exposure to clozapine can Floppy Baby Syndrome
develop? Monitor for Agranulocytosis on a weekly basis for their 1st 6 months of life



What are the two TCAs with the lowest anti-cholinergic Nortriptyline and desipramine
activity?



What SSRI has the lowest transmission into breast milk? Sertraline




A patient is taking Tamoxifen fro breast cancer, what Fluoxetine which is a CYP2D6 inhibitor
SSRI could effect its metabolism?



SSRI with greatest risk of sexual dysfunction? Paroxetine




Viral Meningitis CSF Findings Elevated protein, clear CSF, normal or elevated opening pressure, normal
glucose, WBC 10-10,000 with majority lymphocytes,



Bacterial Meningitis CSF Findings High WBC esp neutrophils, high protein, low glucose




N-Acetylcysteine can be used to treat? Trichitillomania




Dhat Fear of semen in urine




Brain Fag Africa




NMDA Receptor Antagonist Ketamine




Reliability definition The extent to which the method of measurement CONSISTENTLY performs




What SSRI can cause lowered caffeine clearance? Fluvoxamine due to CYP1A2 inhibition




Amplification Theory A person's tendency to amplify physical symptoms based on psychological
factors like anxiety or depression

,What drugs can cause ototoxicity? Aminoglycosides (gentamicin)
Vancomycin
Loop DIuretics
Cisplatin
High dose aspirin


What have long alleles of the MAOA-uVNTR promoter panic disorder with agoraphobia
polymorphism been associated with?



We see increased levels of X in the brain of women in BDNF
the luteal phase who have PMDD?



Catecholaminergic disruption seen in Mania




Cholinergic dysfunction seen in Depression




If a pt struggles with sexual dysfunction what would be a Buspirone
good med to use for GAD?



Structural anomalies in what brain region can lead to Planum temporale
dyslexia?



Uses of Valproic Acid Seizures, bipolar mania, migraines




Valproic Acide side effects Polycystic ovarian syndrome, hyperandrogenism, menstrual disorder and
ovulatory failure, hepatotoxicity (black box), hemorrhagic pancreatitis,
thrombocytopenia (monitor platelets)


2 antipsychotics most closely linked to metabolic 1) Clozapine 2) Olanzapine
syndrome?



Paroxetine can cause what type of malformations if Congenital and cardiac malformations
taken in the 1st trimester of pregnancy?



St. John's Wort induces? What drug could this lower? CYP450
Oral contraceptives
This is an example of a pharmacokinetic drug drug interaction


What influxes when an action potential reaches the Calcium
nerve terminal?



For OCD tx what parts of the brain does deep brain Ventral anterior limb in the internal capsule and ventral striatum
stimulation target?



What enzyme does lithium inhibit? Inositol monophosphate




What are three therapies for selective mutism? Defocused communication
Hierarchal exposure
Shaping and social skills training

, For people who can't speak or have hearing problems Leiter INternational Performance scale
what is an intelligence test that can be administered?



Age for Wechsler Preschool and Performance Scale 2-7 years old




Age for Wechsler Intelligence Scale for Children? 6 to 16 years old




What medications can treat the cognitive symptoms of Acetylcholinesterase inhibitors like donepizil and rivastigmine
lewy body dementia?



What drug can cause a persistent psychotic episode with Phencyclidine aka PCP aka angel dust
a full range of symptoms that look like schizophrenia?



What is the amino acid precursor for all cetecholamines? Tyrosine




Name the three catecholamines Dopamine -->norepenephrine --> epinephrine




What is the amino acid precursor for serotonin? L-tryptophan




The concurrent use of SSRIS with what type of drug NSAIDS
increases the risk for GI bleed?



What type of rigidity seen in neuromuscular malignant Lead pipe ridgidity
syndrome? Also see hypOreflexia



What are the three dopamine pathways involved in 1) Mesolimbic --> positive psychotic symps (think do the limbo)
schizophrenia and their corresponding symptoms? 2) Mesocortical -->Negative symptoms and cognitive symptoms
2) Nigrostriatal --> EPS


FDA approved meds for bipolar depression 1) Olanxapine + fluoxetine (symbyax)
2) Quetiapine
3) lurasidone


What is lamotrigine's FDA indication for treatment of It is only FDA approved for maintenance treatment, not acute episodes.
mania?



What should you do before a pregnant patient is about to Drop the dose by about 50% right before delivery dur to falling fluid levels
give birth if they are taking lithium? i



Name three side effects of valproate in women Polycystic ovarian syndrome
Can cause neural tube defects in pregnancy
Can decrease efficacy of OCPs


What are two drugs that can be used for bipolar disorder Valproate
that can decrease levels of OCP? Carbamazepine

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