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WGU D115 Unit 2 – Complete Study Guide, Practice Questions, and Objective Assessment Preparation

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This document provides comprehensive preparation for Unit 2 of the WGU D115 Advanced Pathophysiology course, featuring exam-style practice questions and detailed review material covering the key concepts assessed in the Objective Assessment (OA). It focuses on the foundational pathophysiology concepts introduced in Unit 2, helping students strengthen their understanding of disease processes, cellular mechanisms, and clinical reasoning in preparation for the OA.

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WGU D115 UNIT 2 WITH
QUESTIONS AND ACCURATE
DETAILED ANSWERS GRADED
A+ 2026
Which type of genetic disease affects males more frequently than females?



Sex-linked recessive

Autosomal recessive

Autosomal dominant

Sex-linked dominant - answer-Sex-Linked recessive. Since males only have one X and
one Y, if the affected chromosome has the illness, it will be expressed.



In which two conditions are chromosomal abnormalities the leading known cause?



Intellectual disability

Respiratory disorders

Fetal miscarriage

Cardiovascular disease

Mental illness

Check My Answer - answer-Intellectual disability and fetal miscarriage. Chromosome
abnormalities are the leading known cause of intellectual disability and fetal
miscarriage.



What are three examples of prenatal diagnostic studies?

Drug-sensitivity testing

Chorionic villus sampling (CVS)

Microscopy of cervical mucosa

, Preimplantation genetic testing (PGT)

Amniocentesis - answer-Chorionic villus sampling (CVS), amniocentesis, and
preimplantation genetic testing (PGT) are examples of prenatal diagnostic studies and
are performed in vitro. CVS is a form of genetic testing that provides genetic information
found in utero and is usually performed between weeks 11 and 14 of pregnancy. An
amniocentesis is a form of genetic testing that evaluates amniotic fluid and is usually
performed during the second trimester, between weeks 15 and 20 of pregnancy. PGT is
performed on the embryo prior to implantation.



Which genetic disorder is characterized by the presence of a zygote having one
chromosome with a normal complement of genes and one chromosome with a missing
gene?

Klinefelter syndrome

Down syndrome

Cri du chat syndrome

Turner syndrome - answer-Cri du chat syndrome (translated as "cry of the cat") is
caused by a DNA deletion. This term describes the cry often heard from a baby affected
by the syndrome. Cri du chat syndrome can present as a microcephalic, low birth-
weight baby with a piercing cry.



How can an X-linked recessive disease skip generations?



Mothers cannot pass X-linked genes to their sons.

Females are hemizygous for the X chromosome.

The disease can be transmitted through female carriers.

These diseases need only one copy of the gene in females. - answer-The disease can be
transmitted through female carriers.



Since females have two copies of the X chromosome, the mother may provide an
unaffected X to a daughter or son. Furthermore, a daughter may not show signs of the
disease because she has the other X (the only X the father can give to a female) to
cancel it out.

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