KATZUNG'S BASIC AND
CLINICAL PHARMACOLOGY
16TH EDITION
• AUTHOR(S)TODD W.
VANDERAH
TEST BANK
,Question 1
A nurse is reviewing the concept of drug selectivity. Which
statement best describes a selective drug?
A. It affects all body systems equally
B. It targets a specific receptor at therapeutic doses
C. It produces only therapeutic effects without side effects
D. It is effective only in high doses
Correct Answer: B
Rationale:
Selective drugs primarily bind to specific receptors at
therapeutic doses, producing targeted effects. However, no
drug is completely selective, especially at higher doses. Option
A is incorrect because drugs do not affect all systems equally.
Option C is incorrect because all drugs can have side effects.
Option D is incorrect because selectivity is typically observed at
lower, not higher, doses.
Question 2
A nurse explains pharmacokinetics to a student. Which process
describes the movement of a drug from the bloodstream into
body tissues?
A. Absorption
B. Distribution
,C. Metabolism
D. Excretion
Correct Answer: B
Rationale:
Distribution refers to the movement of a drug from the
bloodstream into tissues and organs. Absorption (A) is the
movement into the bloodstream. Metabolism (C) involves
chemical alteration, usually in the liver. Excretion (D) is
elimination from the body.
Question 3
A patient asks why a medication must undergo clinical trials
before approval. What is the nurse’s best response?
A. To determine the drug’s color and taste
B. To ensure safety and effectiveness in humans
C. To reduce the cost of the medication
D. To eliminate all side effects before use
Correct Answer: B
Rationale:
Clinical trials are conducted to assess safety, efficacy, dosage,
and adverse effects in humans. Option A is irrelevant. Option C
is not the purpose of trials. Option D is incorrect because no
drug is completely free of side effects.
Question 4
, A nurse is teaching about drug metabolism. Which organ is
primarily responsible for drug metabolism?
A. Kidney
B. Liver
C. Heart
D. Lungs
Correct Answer: B
Rationale:
The liver is the primary organ responsible for drug metabolism
via enzyme systems such as cytochrome P450. The kidneys (A)
primarily handle excretion. The heart (C) and lungs (D) are not
primary metabolic organs.
Question 5
A nurse notes that a drug has a narrow therapeutic index. What
is the priority nursing implication?
A. The drug is safe at any dose
B. Frequent monitoring is required
C. The drug has no side effects
D. The drug is rapidly excreted
Correct Answer: B
Rationale:
A narrow therapeutic index means there is a small margin
between therapeutic and toxic doses, requiring close
CLINICAL PHARMACOLOGY
16TH EDITION
• AUTHOR(S)TODD W.
VANDERAH
TEST BANK
,Question 1
A nurse is reviewing the concept of drug selectivity. Which
statement best describes a selective drug?
A. It affects all body systems equally
B. It targets a specific receptor at therapeutic doses
C. It produces only therapeutic effects without side effects
D. It is effective only in high doses
Correct Answer: B
Rationale:
Selective drugs primarily bind to specific receptors at
therapeutic doses, producing targeted effects. However, no
drug is completely selective, especially at higher doses. Option
A is incorrect because drugs do not affect all systems equally.
Option C is incorrect because all drugs can have side effects.
Option D is incorrect because selectivity is typically observed at
lower, not higher, doses.
Question 2
A nurse explains pharmacokinetics to a student. Which process
describes the movement of a drug from the bloodstream into
body tissues?
A. Absorption
B. Distribution
,C. Metabolism
D. Excretion
Correct Answer: B
Rationale:
Distribution refers to the movement of a drug from the
bloodstream into tissues and organs. Absorption (A) is the
movement into the bloodstream. Metabolism (C) involves
chemical alteration, usually in the liver. Excretion (D) is
elimination from the body.
Question 3
A patient asks why a medication must undergo clinical trials
before approval. What is the nurse’s best response?
A. To determine the drug’s color and taste
B. To ensure safety and effectiveness in humans
C. To reduce the cost of the medication
D. To eliminate all side effects before use
Correct Answer: B
Rationale:
Clinical trials are conducted to assess safety, efficacy, dosage,
and adverse effects in humans. Option A is irrelevant. Option C
is not the purpose of trials. Option D is incorrect because no
drug is completely free of side effects.
Question 4
, A nurse is teaching about drug metabolism. Which organ is
primarily responsible for drug metabolism?
A. Kidney
B. Liver
C. Heart
D. Lungs
Correct Answer: B
Rationale:
The liver is the primary organ responsible for drug metabolism
via enzyme systems such as cytochrome P450. The kidneys (A)
primarily handle excretion. The heart (C) and lungs (D) are not
primary metabolic organs.
Question 5
A nurse notes that a drug has a narrow therapeutic index. What
is the priority nursing implication?
A. The drug is safe at any dose
B. Frequent monitoring is required
C. The drug has no side effects
D. The drug is rapidly excreted
Correct Answer: B
Rationale:
A narrow therapeutic index means there is a small margin
between therapeutic and toxic doses, requiring close
