GUILLAIN-BARRÉ
SYNDROME &
TRANVERSE
MYELLITUS
, “Guillain-Barré Syndrome (GBS) is an acute,
immune-mediated polyradiculoneuropathy
characterized by rapidly progressive,
symmetrical limb weakness and diminished
or absent deep tendon reflexes resulting
from inflammation and damage to the
Definition peripheral nerves and nerve roots.”
• GBS is a neurological emergency and a leading cause of
acute neuromuscular paralysis requiring ICU admission.
, •Incidence: 1–2 cases per 100,000
population annually
•Most common cause of acute flaccid
paralysis worldwide
•Can occur at any age, but incidence
increases with age
•Slight male predominance (male : female ≈
1.5:1)
•Often preceded by an infectious illness in
Epidemiolog approximately
two-thirds of patients
y •Mortality rate: 3–7%, mainly due to
respiratory and
autonomic complications
SYNDROME &
TRANVERSE
MYELLITUS
, “Guillain-Barré Syndrome (GBS) is an acute,
immune-mediated polyradiculoneuropathy
characterized by rapidly progressive,
symmetrical limb weakness and diminished
or absent deep tendon reflexes resulting
from inflammation and damage to the
Definition peripheral nerves and nerve roots.”
• GBS is a neurological emergency and a leading cause of
acute neuromuscular paralysis requiring ICU admission.
, •Incidence: 1–2 cases per 100,000
population annually
•Most common cause of acute flaccid
paralysis worldwide
•Can occur at any age, but incidence
increases with age
•Slight male predominance (male : female ≈
1.5:1)
•Often preceded by an infectious illness in
Epidemiolog approximately
two-thirds of patients
y •Mortality rate: 3–7%, mainly due to
respiratory and
autonomic complications
