NR 565
Advanced Pharmacology
Fundamentals
Midterm and Final Exam
Study Guide
(300 Questions)
Correct Answers
Latest 2026-
Chamberlain College
,The process by which drugs are absorbed, distributed within the body,
metabolized, and excreted. - CORRECT ANSWER
>>>Pharmacokinetics
The study of what the drug does to the body - CORRECT
ANSWER >>>Pharmacodynamics
Rate of dissolution
Surface area
Blood flow
Lipid solubility
pH partitioning - CORRECT ANSWER >>>Factors Affecting Drug
Absorption
Blood flow to tissues
Ability to exit the vascular system
Blood-brain barrier
Protein-binding capacity - CORRECT ANSWER >>>Factors
Affecting Drug Distribution
substances that are foreign to the body, usually synthetic chemical
compounds; medications are a common example - CORRECT ANSWER
>>>Xenobiotics
xenobiotic-metabolizing enzymes necessary for the production of
cholesterol and steroids and the detoxification of chemicals and drug
metabolism. - CORRECT ANSWER >>>Cytochrome
P450 (CYP450)
responsible for phase 1 metabolism in which drugs are oxidized, reduced,
or hydrolyzed - CORRECT ANSWER
>>>Function of Cytochrome P450 (CYP450)
Oxidation; Reduction; Hydrolysis - CORRECT ANSWER >>>Phase
1 Metabolism of Drugs via P450
,
, -Drug becomes completely inactive
-Drug becomes partially inactive but one or more metabolites remain active
-Original drug is not pharmacologically active but one metabolite remains
active - CORRECT ANSWER >>>Three possible outcomes of phase 1 drug
metabolism.
Medications that can increase the rate of another drug's metabolism by
elevating CYP450 enzyme activity via increasing enzyme synthesis.
decreasing the concentration of the "parent
drug" - CORRECT ANSWER >>>CYP450 Inducers
CRAPGPS
Carbamazepine
Rifampin
Alcohol
Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas - CORRECT ANSWER >>>CYP450 Inducer
Medications
Medications that inhibit the metabolic activity of one or more of the CYP450
enzymes. Higher risk for toxicity; prolongs the pharmacological effect of
the "parent drug". - CORRECT
ANSWER >>>CYP450 Inhibitors
VISACKGQ
Valproate
Isoniazid
Sulfonamides
Amiodarone
Chloramphenicol
Ketoconazole
Grapefruit Juice
Quinidine - CORRECT ANSWER >>>CYP450 Inhibitor
Medications
-potentially Inappropriate Medication (PIM) use in older adults -potentially
Inappropriate Medication (PIM) use in older adults due to medication-
Advanced Pharmacology
Fundamentals
Midterm and Final Exam
Study Guide
(300 Questions)
Correct Answers
Latest 2026-
Chamberlain College
,The process by which drugs are absorbed, distributed within the body,
metabolized, and excreted. - CORRECT ANSWER
>>>Pharmacokinetics
The study of what the drug does to the body - CORRECT
ANSWER >>>Pharmacodynamics
Rate of dissolution
Surface area
Blood flow
Lipid solubility
pH partitioning - CORRECT ANSWER >>>Factors Affecting Drug
Absorption
Blood flow to tissues
Ability to exit the vascular system
Blood-brain barrier
Protein-binding capacity - CORRECT ANSWER >>>Factors
Affecting Drug Distribution
substances that are foreign to the body, usually synthetic chemical
compounds; medications are a common example - CORRECT ANSWER
>>>Xenobiotics
xenobiotic-metabolizing enzymes necessary for the production of
cholesterol and steroids and the detoxification of chemicals and drug
metabolism. - CORRECT ANSWER >>>Cytochrome
P450 (CYP450)
responsible for phase 1 metabolism in which drugs are oxidized, reduced,
or hydrolyzed - CORRECT ANSWER
>>>Function of Cytochrome P450 (CYP450)
Oxidation; Reduction; Hydrolysis - CORRECT ANSWER >>>Phase
1 Metabolism of Drugs via P450
,
, -Drug becomes completely inactive
-Drug becomes partially inactive but one or more metabolites remain active
-Original drug is not pharmacologically active but one metabolite remains
active - CORRECT ANSWER >>>Three possible outcomes of phase 1 drug
metabolism.
Medications that can increase the rate of another drug's metabolism by
elevating CYP450 enzyme activity via increasing enzyme synthesis.
decreasing the concentration of the "parent
drug" - CORRECT ANSWER >>>CYP450 Inducers
CRAPGPS
Carbamazepine
Rifampin
Alcohol
Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas - CORRECT ANSWER >>>CYP450 Inducer
Medications
Medications that inhibit the metabolic activity of one or more of the CYP450
enzymes. Higher risk for toxicity; prolongs the pharmacological effect of
the "parent drug". - CORRECT
ANSWER >>>CYP450 Inhibitors
VISACKGQ
Valproate
Isoniazid
Sulfonamides
Amiodarone
Chloramphenicol
Ketoconazole
Grapefruit Juice
Quinidine - CORRECT ANSWER >>>CYP450 Inhibitor
Medications
-potentially Inappropriate Medication (PIM) use in older adults -potentially
Inappropriate Medication (PIM) use in older adults due to medication-
