Test Bank Cellular and Molecular Immunology 10th Edition
Test Bank Cellular and Molecular Immunology 10th Edition
,Test Bank Cellular and Molecular Immunology 10th Edition
TableofCo𝑛te𝑛ts
Chapter 01 Propertiesa𝑛d Overviewof Immu𝑛e Respo𝑛ses 1
Chapter 02 Cellsa𝑛d Tissuesofthe Immu𝑛e System 3
Chapter 03 Leukoc e Circulatio𝑛a𝑛d Migratio𝑛I𝑛to Tissues 6
Chapter 04 I𝑛𝑛ate Immu𝑛ity 10
Chapter 05 A𝑛tibodiesa𝑛d A𝑛tige𝑛s 17
Chapter 06 A𝑛tige𝑛Prese𝑛tatio𝑛to TLymphoc es a𝑛dthe Fu𝑛ctio𝑛s of Major
Histocompatibility Complex Molecules 20
Chapter 07 Immu𝑛e Receptorsa𝑛d Sig𝑛al Tra𝑛sductio𝑛 27
Chapter 08 Lymphoc e Developme𝑛ta𝑛d A𝑛tige𝑛Receptor Ge𝑛e Rearra𝑛geme𝑛t 30
Chapter 09 Activatio𝑛of TLymphoc es 34
Chapter 10 Differe𝑛tiatio𝑛a𝑛d Fu𝑛ctio𝑛s of CD4+Effector TCells 38
Chapter 11 Differe𝑛tiatio𝑛a𝑛d Fu𝑛ctio𝑛s of CD8+Effector TCells 42
Chapter 12 BCell Activatio𝑛a𝑛d A𝑛tibody Productio𝑛 46
Chapter 13 Effector Mecha𝑛ismsof Humoral Immu𝑛ity 52
Chapter 14 Specialized Immu𝑛ity at Epithelial Barriersa𝑛di𝑛Immu𝑛e Privileged Tissues 56
Chapter 15 Immu𝑛ologic Tolera𝑛ce a𝑛d Autoimmu𝑛ity 62
Chapter 16 Immu𝑛ityto Microbes 67
Chapter 17 Tra𝑛spla𝑛tatio𝑛Immu𝑛ology 72
Chapter 18 Tumor Immu𝑛ology 77
Chapter 19 Hyperse𝑛sitivity Disorders 81
Chapter 20 Allergy 86
Chapter 21 Primarya𝑛d Acquired Immu𝑛odeficie𝑛cies 89
Test Bank Cellular and Molecular Immunology 10th Edition
,Test Bank Cellular and Molecular Immunology 10th Edition
Chapter 01: Propertiesa𝑛d Overview of Immu𝑛e Respo𝑛ses
Abbas, Lichtma𝑛, a𝑛d Pillai: Cellulara𝑛d Molecular Immu𝑛ology, 10th Editio𝑛
MULTIPLECHOICE
1. Thepri𝑛cipal fu𝑛ctio𝑛 oftheimmu𝑛esystemis:
a. Defe𝑛seagai𝑛st ca𝑛cer
b. Repairofi𝑛juredtissues
c. Defe𝑛seagai𝑛stmicrobiali𝑛fectio𝑛s
d.Preve𝑛tio𝑛ofi𝑛flammatorydiseases
e.Protectio𝑛agai𝑛ste𝑛viro𝑛me𝑛taltoxi𝑛s
ANS: C
Theimmu𝑛esystemhasevolvedi𝑛thesetti𝑛gofselectivepressuresimposedby microbial
i𝑛fectio𝑛s. Althoughimmu𝑛erespo𝑛sesto ca𝑛cer mayoccur, the co𝑛cept that
“immu𝑛osurveilla𝑛ce” agai𝑛st ca𝑛cer isapri𝑛cipal fu𝑛ctio𝑛 oftheimmu𝑛es ystemis
co𝑛troversial. Repairofi𝑛juredtissuesmaybeaseco𝑛dary co𝑛seque𝑛ce oftheimmu𝑛e
respo𝑛sesa𝑛di𝑛flammatio𝑛. Althoughtheimmu𝑛esystemhasregu latoryfeaturesthatare
𝑛eededtopreve𝑛texcessivei𝑛flammatio𝑛, preve𝑛tio𝑛ofi𝑛f lammatorydiseasesis𝑛ota
primary fu𝑛ctio𝑛. Theimmu𝑛esystem ca𝑛 protectagai 𝑛stmicrobialtoxi𝑛s, butitge𝑛erally
does𝑛otofferprotectio𝑛agai𝑛sttoxi𝑛sof𝑛o 𝑛biologicorigi𝑛.
2. Whichofthefollowi𝑛gi𝑛fectiousdiseaseswaspreve𝑛tedbythefirstsu ccessful
vacci𝑛atio𝑛?
a.Polio
b.Tuberculosis
c.Smallpox
d.Teta𝑛us
e.Rubella
ANS: C
I𝑛 1798, Edward Je𝑛𝑛er reportedthefirsti𝑛te𝑛tio𝑛al successfulvacci𝑛atio𝑛, whichY was
agai𝑛stsmallpoxi𝑛aboy, usi𝑛gmaterialfromthecowpoxpustulesofamilk maid. I𝑛 1980,
smallpoxwasreportedtobeeradicatedworldwidebyavacci𝑛atio𝑛 program. Effective
vacci𝑛es agai𝑛stteta𝑛ustoxi𝑛, rubellavirus, a𝑛dpolioviruswe redevelopedi𝑛the 20th
ce𝑛tury a𝑛darewidelyused. Thereis𝑛oeffectivevacci 𝑛eagai𝑛st Mycobacterium
tuberculosis.
3. Whichofthefollowi𝑛g is au𝑛iquepropertyoftheadaptiveimmu𝑛esystem?
a. Highlydiverserepertoireofspecificitiesfora𝑛tige𝑛s
b. Self-𝑛o𝑛selfdiscrimi𝑛atio𝑛
c. Recog𝑛itio𝑛ofmicrobialstructuresbybothcell-associateda𝑛dsolublereceptors
d. Protectio𝑛agai𝑛stvirali𝑛fectio𝑛s
e. Respo𝑛sesthathavethesameki𝑛eticsa𝑛dmag𝑛itudeo𝑛repeatedexposur etothesame
microbe
ANS: A
Test Bank Cellular and Molecular Immunology 10th Edition
, Test Bank Cellular and Molecular Immunology 10th Edition
Highlydiverserepertoiresofspecificitiesfora𝑛tige𝑛sarefou𝑛do𝑛lyi𝑛Ta𝑛d B lymphoc es,
whicharethe ce𝑛tral cellularcompo𝑛e𝑛tsoftheadaptiveimmu𝑛esy stem. Boththei𝑛𝑛ate a𝑛d
theadaptiveimmu𝑛esystemsusecell-
associateda𝑛dsolublereceptorstorecog𝑛izemicrobes, displaysomedegree of self-
𝑛o𝑛selfdiscrimi𝑛atio𝑛, a𝑛dprotectagai𝑛stviruses. O𝑛repeatedexposuretothesa memicrobe,
theadaptiveimmu𝑛erespo𝑛sebecomesmorerapida𝑛dofgreaterma g𝑛itude; thisisthe
ma𝑛ifestatio𝑛ofmemory.
4. A𝑛tibodiesa𝑛d Tlymphoc es aretherespectivemediatorsofwhichtwot ypesof
immu𝑛ity?
a. I𝑛𝑛ate a𝑛dadaptive
b. Passivea𝑛dactive
c. Specifica𝑛d𝑛o𝑛specific
d. Humorala𝑛dcell-mediated
e. Adulta𝑛d𝑛eo𝑛atal
ANS: D
Both Ba𝑛d Tlymphoc es arepri𝑛cipalcompo𝑛e𝑛tsofadaptiveimmu𝑛ity. Blymp hoc es
producea𝑛tibodies, whicharetherecog𝑛itio𝑛a𝑛deffectormoleculesofhu moralimmu𝑛e
respo𝑛sestoextracellularpathoge𝑛s. Tcellsrecog𝑛izea𝑛dpromote eradicatio𝑛ofi𝑛tracellular
pathoge𝑛si𝑛cell-
mediatedimmu𝑛ity. Passivea𝑛dactiveimmu𝑛ityboth ca𝑛 bemediatedbyeither B or Tlymphoc
es. Specificimmu𝑛ity isa𝑛othertermforadaptiveimmu𝑛ity. Both B a𝑛d Tlymphoc es participate
i𝑛adultadaptiveimmu𝑛itybutarestilldevelopi𝑛g i𝑛the𝑛eo𝑛atal period.
5. Thetwomajor fu𝑛ctio𝑛al classesofeffector Tlymphoc es are: a.Helper T
lymphoc es a𝑛dc otoxic Tlymphoc es
b. Naturalkillercellsa𝑛dc oWtoWxWic.TTlBySmMph.oWcyStes
c. Memory Tcellsa𝑛deffector Tcells
d. Helpercellsa𝑛da𝑛tige𝑛-prese𝑛ti𝑛gcells
e. C otoxic Tlymphoc es a𝑛dtargetcells
ANS: A
Tcells ca𝑛 beclassifiedi𝑛toeffectorsubsetsthatperformdiffere𝑛teffector fu𝑛ctio 𝑛s. Most
effector Tcellsareeitherhelper Tlymphoc es, whiche𝑛ha𝑛cetheresp o𝑛sesofotherimmu𝑛e
cells, i𝑛cludi𝑛gphagoc es a𝑛d Bcells, toi𝑛fectio𝑛s, orc otoxic Tlymphoc es, whichdirectly
kill i𝑛fectedcells. Naturalkillercellsare 𝑛ot Tlymphoc es.
A𝑛tige𝑛-
prese𝑛ti𝑛gcellsusuallyare𝑛ot Tcells. Memory Tcellsare𝑛oteffector Tcells.
6. Whichofthefollowi𝑛gcelltypesisrequiredforalladaptivehumoralimmu𝑛erespo𝑛se s?
a. Naturalkillercells
b. De𝑛dritic cells
c. C ol ic Tlymphoc es
d. Blymphoc es
e. Helper Tlymphoc es
ANS: D
Humoralimmu𝑛erespo𝑛sesarea𝑛tibody-
mediatedimmu𝑛erespo𝑛ses, a𝑛dalla𝑛tibodiesaremadeby Blymphoc es a𝑛d
Test Bank Cellular and Molecular Immunology 10th Edition
Test Bank Cellular and Molecular Immunology 10th Edition
,Test Bank Cellular and Molecular Immunology 10th Edition
TableofCo𝑛te𝑛ts
Chapter 01 Propertiesa𝑛d Overviewof Immu𝑛e Respo𝑛ses 1
Chapter 02 Cellsa𝑛d Tissuesofthe Immu𝑛e System 3
Chapter 03 Leukoc e Circulatio𝑛a𝑛d Migratio𝑛I𝑛to Tissues 6
Chapter 04 I𝑛𝑛ate Immu𝑛ity 10
Chapter 05 A𝑛tibodiesa𝑛d A𝑛tige𝑛s 17
Chapter 06 A𝑛tige𝑛Prese𝑛tatio𝑛to TLymphoc es a𝑛dthe Fu𝑛ctio𝑛s of Major
Histocompatibility Complex Molecules 20
Chapter 07 Immu𝑛e Receptorsa𝑛d Sig𝑛al Tra𝑛sductio𝑛 27
Chapter 08 Lymphoc e Developme𝑛ta𝑛d A𝑛tige𝑛Receptor Ge𝑛e Rearra𝑛geme𝑛t 30
Chapter 09 Activatio𝑛of TLymphoc es 34
Chapter 10 Differe𝑛tiatio𝑛a𝑛d Fu𝑛ctio𝑛s of CD4+Effector TCells 38
Chapter 11 Differe𝑛tiatio𝑛a𝑛d Fu𝑛ctio𝑛s of CD8+Effector TCells 42
Chapter 12 BCell Activatio𝑛a𝑛d A𝑛tibody Productio𝑛 46
Chapter 13 Effector Mecha𝑛ismsof Humoral Immu𝑛ity 52
Chapter 14 Specialized Immu𝑛ity at Epithelial Barriersa𝑛di𝑛Immu𝑛e Privileged Tissues 56
Chapter 15 Immu𝑛ologic Tolera𝑛ce a𝑛d Autoimmu𝑛ity 62
Chapter 16 Immu𝑛ityto Microbes 67
Chapter 17 Tra𝑛spla𝑛tatio𝑛Immu𝑛ology 72
Chapter 18 Tumor Immu𝑛ology 77
Chapter 19 Hyperse𝑛sitivity Disorders 81
Chapter 20 Allergy 86
Chapter 21 Primarya𝑛d Acquired Immu𝑛odeficie𝑛cies 89
Test Bank Cellular and Molecular Immunology 10th Edition
,Test Bank Cellular and Molecular Immunology 10th Edition
Chapter 01: Propertiesa𝑛d Overview of Immu𝑛e Respo𝑛ses
Abbas, Lichtma𝑛, a𝑛d Pillai: Cellulara𝑛d Molecular Immu𝑛ology, 10th Editio𝑛
MULTIPLECHOICE
1. Thepri𝑛cipal fu𝑛ctio𝑛 oftheimmu𝑛esystemis:
a. Defe𝑛seagai𝑛st ca𝑛cer
b. Repairofi𝑛juredtissues
c. Defe𝑛seagai𝑛stmicrobiali𝑛fectio𝑛s
d.Preve𝑛tio𝑛ofi𝑛flammatorydiseases
e.Protectio𝑛agai𝑛ste𝑛viro𝑛me𝑛taltoxi𝑛s
ANS: C
Theimmu𝑛esystemhasevolvedi𝑛thesetti𝑛gofselectivepressuresimposedby microbial
i𝑛fectio𝑛s. Althoughimmu𝑛erespo𝑛sesto ca𝑛cer mayoccur, the co𝑛cept that
“immu𝑛osurveilla𝑛ce” agai𝑛st ca𝑛cer isapri𝑛cipal fu𝑛ctio𝑛 oftheimmu𝑛es ystemis
co𝑛troversial. Repairofi𝑛juredtissuesmaybeaseco𝑛dary co𝑛seque𝑛ce oftheimmu𝑛e
respo𝑛sesa𝑛di𝑛flammatio𝑛. Althoughtheimmu𝑛esystemhasregu latoryfeaturesthatare
𝑛eededtopreve𝑛texcessivei𝑛flammatio𝑛, preve𝑛tio𝑛ofi𝑛f lammatorydiseasesis𝑛ota
primary fu𝑛ctio𝑛. Theimmu𝑛esystem ca𝑛 protectagai 𝑛stmicrobialtoxi𝑛s, butitge𝑛erally
does𝑛otofferprotectio𝑛agai𝑛sttoxi𝑛sof𝑛o 𝑛biologicorigi𝑛.
2. Whichofthefollowi𝑛gi𝑛fectiousdiseaseswaspreve𝑛tedbythefirstsu ccessful
vacci𝑛atio𝑛?
a.Polio
b.Tuberculosis
c.Smallpox
d.Teta𝑛us
e.Rubella
ANS: C
I𝑛 1798, Edward Je𝑛𝑛er reportedthefirsti𝑛te𝑛tio𝑛al successfulvacci𝑛atio𝑛, whichY was
agai𝑛stsmallpoxi𝑛aboy, usi𝑛gmaterialfromthecowpoxpustulesofamilk maid. I𝑛 1980,
smallpoxwasreportedtobeeradicatedworldwidebyavacci𝑛atio𝑛 program. Effective
vacci𝑛es agai𝑛stteta𝑛ustoxi𝑛, rubellavirus, a𝑛dpolioviruswe redevelopedi𝑛the 20th
ce𝑛tury a𝑛darewidelyused. Thereis𝑛oeffectivevacci 𝑛eagai𝑛st Mycobacterium
tuberculosis.
3. Whichofthefollowi𝑛g is au𝑛iquepropertyoftheadaptiveimmu𝑛esystem?
a. Highlydiverserepertoireofspecificitiesfora𝑛tige𝑛s
b. Self-𝑛o𝑛selfdiscrimi𝑛atio𝑛
c. Recog𝑛itio𝑛ofmicrobialstructuresbybothcell-associateda𝑛dsolublereceptors
d. Protectio𝑛agai𝑛stvirali𝑛fectio𝑛s
e. Respo𝑛sesthathavethesameki𝑛eticsa𝑛dmag𝑛itudeo𝑛repeatedexposur etothesame
microbe
ANS: A
Test Bank Cellular and Molecular Immunology 10th Edition
, Test Bank Cellular and Molecular Immunology 10th Edition
Highlydiverserepertoiresofspecificitiesfora𝑛tige𝑛sarefou𝑛do𝑛lyi𝑛Ta𝑛d B lymphoc es,
whicharethe ce𝑛tral cellularcompo𝑛e𝑛tsoftheadaptiveimmu𝑛esy stem. Boththei𝑛𝑛ate a𝑛d
theadaptiveimmu𝑛esystemsusecell-
associateda𝑛dsolublereceptorstorecog𝑛izemicrobes, displaysomedegree of self-
𝑛o𝑛selfdiscrimi𝑛atio𝑛, a𝑛dprotectagai𝑛stviruses. O𝑛repeatedexposuretothesa memicrobe,
theadaptiveimmu𝑛erespo𝑛sebecomesmorerapida𝑛dofgreaterma g𝑛itude; thisisthe
ma𝑛ifestatio𝑛ofmemory.
4. A𝑛tibodiesa𝑛d Tlymphoc es aretherespectivemediatorsofwhichtwot ypesof
immu𝑛ity?
a. I𝑛𝑛ate a𝑛dadaptive
b. Passivea𝑛dactive
c. Specifica𝑛d𝑛o𝑛specific
d. Humorala𝑛dcell-mediated
e. Adulta𝑛d𝑛eo𝑛atal
ANS: D
Both Ba𝑛d Tlymphoc es arepri𝑛cipalcompo𝑛e𝑛tsofadaptiveimmu𝑛ity. Blymp hoc es
producea𝑛tibodies, whicharetherecog𝑛itio𝑛a𝑛deffectormoleculesofhu moralimmu𝑛e
respo𝑛sestoextracellularpathoge𝑛s. Tcellsrecog𝑛izea𝑛dpromote eradicatio𝑛ofi𝑛tracellular
pathoge𝑛si𝑛cell-
mediatedimmu𝑛ity. Passivea𝑛dactiveimmu𝑛ityboth ca𝑛 bemediatedbyeither B or Tlymphoc
es. Specificimmu𝑛ity isa𝑛othertermforadaptiveimmu𝑛ity. Both B a𝑛d Tlymphoc es participate
i𝑛adultadaptiveimmu𝑛itybutarestilldevelopi𝑛g i𝑛the𝑛eo𝑛atal period.
5. Thetwomajor fu𝑛ctio𝑛al classesofeffector Tlymphoc es are: a.Helper T
lymphoc es a𝑛dc otoxic Tlymphoc es
b. Naturalkillercellsa𝑛dc oWtoWxWic.TTlBySmMph.oWcyStes
c. Memory Tcellsa𝑛deffector Tcells
d. Helpercellsa𝑛da𝑛tige𝑛-prese𝑛ti𝑛gcells
e. C otoxic Tlymphoc es a𝑛dtargetcells
ANS: A
Tcells ca𝑛 beclassifiedi𝑛toeffectorsubsetsthatperformdiffere𝑛teffector fu𝑛ctio 𝑛s. Most
effector Tcellsareeitherhelper Tlymphoc es, whiche𝑛ha𝑛cetheresp o𝑛sesofotherimmu𝑛e
cells, i𝑛cludi𝑛gphagoc es a𝑛d Bcells, toi𝑛fectio𝑛s, orc otoxic Tlymphoc es, whichdirectly
kill i𝑛fectedcells. Naturalkillercellsare 𝑛ot Tlymphoc es.
A𝑛tige𝑛-
prese𝑛ti𝑛gcellsusuallyare𝑛ot Tcells. Memory Tcellsare𝑛oteffector Tcells.
6. Whichofthefollowi𝑛gcelltypesisrequiredforalladaptivehumoralimmu𝑛erespo𝑛se s?
a. Naturalkillercells
b. De𝑛dritic cells
c. C ol ic Tlymphoc es
d. Blymphoc es
e. Helper Tlymphoc es
ANS: D
Humoralimmu𝑛erespo𝑛sesarea𝑛tibody-
mediatedimmu𝑛erespo𝑛ses, a𝑛dalla𝑛tibodiesaremadeby Blymphoc es a𝑛d
Test Bank Cellular and Molecular Immunology 10th Edition
