ASCP MLT CHEMISTRY EXAM STUDY GUIDE 2026/2027 ACCURATE QUESTIONS WITH CORRECT DETAILED SOLUTIONS || 100% GUARANTEED PASS NEWEST VERSION

ASCP MLT CHEMISTRY EXAM STUDY GUIDE 2026/2027 ACCURATE QUESTIONS WITH CORRECT DETAILED SOLUTIONS || 100% GUARANTEED PASS NEWEST VERSION 1. Which one of the following statements about acetaminophen metabolism is false? Choose the single best answer A. It is metabolized in the kidney B. It is largely metabolized in the liver to glucuronide and sulfonate conjugates C. A small amount is metabolized via cytochrome oxidase to a reactive benzoquinoneimine intermediate D. This intermediate becomes toxic to the liver once tissue glutathione becomes depleted - ANSWER A; The benzoquinoneimine intermediate produced in the liver as a result of hepatic cytochrome oxidase metabolism of acetaminophen is responsible for hepatic necrosis via acylation of hepatic tissue. The treatment of acetaminophen toxicity includes the use of N-acetylcysteine (Mucomyst), which acts as a glutathione substitute. The risk of hepatotoxicity is predicted with the Rumack Matthew nomogram, which uses the hours after ingestion and plasma acetaminophen level to predict the probability of hepatotoxicity. Severe hepatotoxicity can be fatal. 2. According to the 2010 ADA guidelines, HbA1C percent can be used as an assay to diagnose diabetes. True/False - ANSWER T; The 2010 ADA Clinical Practice Recommendations added measurement of HbA1C as a diagnostic assay for diagnosis of diabetes. 3. Which of the following conditions would make a sample unsuitable for lactic acid testing? Choose the single best answer A. Movement of hand or arm during specimen collection B. Received in the lab on ice C. Centrifuged in a refrigerated centrifuge D. Specimen centrifuged and plasma separated from cells less than 15 minutes after collection - ANSWER A; Movement of the muscles in the hand or arm during specimen collection will falsely increase lactic acid concentration. A blood sample for lactic acid testing should be placed on ice immediately after collection, centrifuged within 15 minutes of collection, and plasma immediately separated from cells following centrifugation. If possible, a refrigerated centrifuge should be used. 4. You are working in a clinical chemistry laboratory and are analyzing a plasma glucose sample. The sample is flagged by the analyzer for being "outside of linear range." You manually dilute the sample 1:2 and rerun it. Again, you receive an "outside linear range" alert. You decide to perform a different manual dilution. This time you manually dilute the original sample again; this time using a 1:3 dilution. The instrument gives you a glucose value of 150 mg/dL from this diluted sample. What is the actual patient glucose result that you should report to the physician? Choose the single best answer A. 100 mg/dL B. 400 mg/dL C. 600 mg/dL D. 450 mg/dL E. 1200 mg/dL - ANSWER D; The correct response is option D: 450 mg/dl. A 1:3 dilution entails mixing one part patient sample with two parts diluent, for a total volume of 3 parts. In laboratory dilutions, the total volume is considered a dilution factor. The dilution factor in this question is 3. So a diluted sample with a value of 150 would need to be multiplied by 3 to obtain the correct final answer. 150 x 3 = 450 mg/dl. 5. A routine serum protein electrophoresis with normal proteins results in _____ zones or bands. A: 5 B: 6 C: 10 D: 12 **This is Level 3 Question** - ANSWER A 6. In an standard electrophoretic separation, what zone appears first (anodal end) on the densitometric pattern? A: Albumin B: A1-globulins C: A2-globulins D: B-globulins **This is Level 2 Question** - ANSWER A 7. Which of the following cardiovascular risk markers is a more sensitive version of a test that is used to assess inflammation? A: Oxidized-LDL B: HS-CRP C: ApoB/ApoA1 D: LpPLA2 **This is Level 2 Question** - ANSWER B 8. How does Aspirin (salicylic acid) affect PLT function? A: Inhibiting cyclooxygenase B: Activates lipids C: Inhibiting carbohydrates D: Activating nucleic acid **This is Level 2 Question** - ANSWER A 9. A patient has optimal LDL & HDL cholesterol values, but a HS-CRP test shows a value of 12mg/L (low cardiovascular risk 1.0mg/L). Which of the following situations is most likely? A: The patient has a marked lipid problem such as metabolic syndrome B: The patient has not been fasting C: The patient has a underlying acute inflammation process D: The patient has been drinking too much water before the specimen was collected, therefore diluting the LDL & HDL values **This is Level 3 Question** - ANSWER C 10. A reaction is in _____ kinetics when the reaction rate depends on enzyme concentration. A: Zero-order B: 1st-order C: 2nd-order D: Mixed-order **This is Level 5 Question** - ANSWER A 11. Which of the following are considered 2 of the POSITIVE risk factors for coronary heart disease as determined by the NCEP? A: LDL-C concentration 100mg/dL; HDL-C concentration = 60mg/dL B: LDL-C concentration = 100mg/dL; HDL-C concentration = 60mg/dL C: LDL-C concentration 100mg/dL; HDL-C concentration = 40mg/dL D: LDL-C concentration = 100mg/dL; HDL-C concentration = 40mg/dL **This is Level 5 Question** - ANSWER D 12. An electrophoretic separation of lactate dehydrogenase isoenzyme that demonstrates elevation in LD-1 greater than LD-2 could be indicative of: A: A normal LD isoenzyme pattern B: Hemolysis C: Pancreatitis D: Hepatic injury **This is Level 7 Question** - ANSWER B