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NBRC TMC Mock Practice Exam Questions & Answers | NBRC TMC | 200+ Questions | Oxygen Therapy, Mechanical Ventilation, ABGs, Airway Management & Respiratory Care | National Board for Respiratory Care (NBRC)

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This comprehensive NBRC Therapist Multiple-Choice (TMC) Mock Practice Exam Questions and Answers study guide contains 200+ exam-style questions with detailed answers covering the essential knowledge and clinical decision-making skills required to successfully prepare for the National Board for Respiratory Care (NBRC) Therapist Multiple-Choice (TMC) Examination. Designed for Respiratory Therapy students, Certified Respiratory Therapist (CRT) candidates, Registered Respiratory Therapist (RRT) candidates, and practicing respiratory care professionals, this resource provides realistic, scenario-based questions that closely reflect the format, complexity, and clinical reasoning required on the official NBRC TMC certification examination. The structured question-and-answer format strengthens critical thinking, reinforces respiratory care concepts, and improves exam readiness through evidence-based clinical scenarios. The study guide comprehensively reviews high-yield respiratory care topics including oxygen therapy, oxygen delivery devices, air-entrainment masks, non-rebreather masks, humidification therapy, aerosol therapy, heated humidifiers, heat and moisture exchangers (HMEs), arterial blood gas (ABG) interpretation, acid-base balance, oxygen content calculations, oxygen cylinder duration calculations, FiO₂ calculations, air-entrainment ratios, mechanical ventilation, ventilator monitoring, ventilator waveforms, static compliance, positive end-expiratory pressure (PEEP), auto-PEEP recognition, airway management, endotracheal intubation, tracheostomy care, cuff pressure management, suctioning techniques, bronchoscopy, chest tube management, pulmonary assessment, cardiac biomarkers, congestive heart failure (CHF), myocardial infarction (MI), pulmonary diseases, COPD management, noninvasive positive pressure ventilation (NPPV), CPAP therapy, respiratory emergencies, patient assessment, respiratory physiology, oxygen transport, airway clearance techniques, and respiratory equipment troubleshooting. These questions closely mirror the clinical competencies and patient-care scenarios assessed on the NBRC TMC examination while reinforcing evidence-based respiratory therapy practice. The content is aligned with the National Board for Respiratory Care (NBRC) Therapist Multiple-Choice (TMC) Examination Content Outline and evidence-based respiratory care standards. Primary references include the NBRC TMC Examination Matrix, Egan's Fundamentals of Respiratory Care (Kacmarek, Stoller & Heuer), Pilbeam's Mechanical Ventilation: Physiological and Clinical Applications, AARC Clinical Practice Guidelines published by the American Association for Respiratory Care (AARC), Clinical Manifestations and Assessment of Respiratory Disease by Des Jardins & Burton, Respiratory Care: Principles and Practice by Hess et al., and the AARC Oxygen Therapy Clinical Practice Guidelines. These authoritative resources establish the evidence-based principles of oxygen therapy, airway management, mechanical ventilation, respiratory assessment, pulmonary diagnostics, humidification, and critical care reflected throughout this certification study guide. Relevant Students: NBRC TMC certification candidates, Registered Respiratory Therapist (RRT) candidates, Certified Respiratory Therapist (CRT) candidates, Respiratory Therapy students, Respiratory Care students, Pulmonary Medicine students, Critical Care students, Intensive Care Unit (ICU) clinicians, Emergency Department respiratory therapists, Mechanical Ventilation students, Cardiopulmonary Care students, Allied Health students, Clinical Respiratory Care instructors, Respiratory Therapy educators, Healthcare professionals preparing for NBRC certification. Keywords: NBRC TMC, NBRC Therapist Multiple Choice, TMC exam, NBRC practice exam, NBRC practice questions, respiratory therapy, respiratory care, RRT exam, CRT exam, oxygen therapy, arterial blood gases, ABG interpretation, acid base balance, oxygen delivery devices, nonrebreather mask, air entrainment mask, humidification therapy, aerosol therapy, heated humidifier, HME, mechanical ventilation, ventilator management, ventilator waveforms, static compliance, PEEP, auto PEEP, airway management, endotracheal intubation, tracheostomy care, suctioning, bronchoscopy, chest tube management, oxygen calculations, FiO₂ calculations, oxygen cylinder duration, COPD, CPAP, NPPV, CHF, myocardial infarction, pulmonary assessment, respiratory physiology, critical care, respiratory equipment, AARC guidelines, respiratory certification, respiratory therapy review, respiratory board exam, NBRC study guide.

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NBRC Mock TMC Exam Review
2026 Exam Questions with
100% Correct Answers | Latest
Update



A patient is receiving O2 from an E cylinder at 4 L/min through a nasal

cannula. The cylinder pressure is 1900 psig. How long will the cylinder

run until it is empty?




A. 47 min

,B. 1.7 h

C. 2.2 h


D. 3.6 h - ANSWER ✔✔E cylinder = 0.28


1900x0.28/4 = 133/60 = 2.21




Answer: C. 2 hours, 21 minutes

After the Respiratory Therapist sets up a nonrebreathing mask on a

patient at a flow rate of 10 L/min, the reservoir bag collapses before the

patient finishes inspiring. The RT should do which of the following?




A. Change to a simple mask at a flow rate of 10 L/min

B. Remove the one-way valve from the exhalation port.

C. Place the patient on continuous positive airway pressure (CPAP)


D. Increase the flow rate to 15 L/min - ANSWER ✔✔D. Increase the

flow rate to 15 L/min

A patient with carbon monoxide (CO) poisoning can best be treated with

which of the following therapies?

, A. Nasal Cannula at 6 L/min

B. Simple O2 mask at 10 L/min

C. CPAP and 60% O2


D. Nonrebreathing mask - ANSWER ✔✔D. Nonrebreathing mask


The following blood gas levels have been obtained from a patient using

a 60% aerosol mask.




pH: 7.47

PaCO2: 31 mmHg

PaO2: 58 mmHg




What should the RT recommend at this time?




A. Place the patient on CPAP

B. Increase the O2 to 70%

C. Intubate and place the patient on mechanical ventilation


D. Change to a nonrebreathing mask - ANSWER ✔✔A. Place the

patient on CPAP

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