COMSAE FORM 113 PRACTICE TEST QUESTIONS AND CORRECT ANSWERS (VERIFIED
ANSWERS) PLUS RATIONALES 2026 Q&A |STUDY GUIDE| INSTANT DOWNLOAD PDF
CORE DOMAINS
Osteopathic principles and manipulative treatment.
Anatomy, physiology, and biochemistry.
Pathology and pathophysiology.
Pharmacology and microbiology.
Behavioral science and ethics.
Preventive medicine and public health.
Internal medicine and family medicine.
Pediatrics, obstetrics, and gynecology.
Surgery, emergency care, and clinical decision-making.
Systems-based practice and professionalism.*
INTRODUCTION
,This practice test is designed to assess foundational biomedical knowledge and clinical reasoning in a format
that mirrors the structure and demands of COMSAE Phase 1 preparation. It emphasizes multiple-choice, case-
based questions that require application of medical science, interpretation of clinical findings, and sound
decision-making. The exam assesses the integration of basic science, osteopathic principles, ethical practice,
and patient-centered care across common and high-yield clinical presentations. Questions are written to
reflect real-world medical scenarios and the judgment expected of future osteopathic physicians.
SECTION ONE
, . A 22-year-old college student develops sore throat, fever, and posterior cervical lymphadenopathy. He is
diagnosed with infectious mononucleosis. Which complication is most important to counsel him about?
A. 🟢 Splenic rupture
B. Otitis media
C. Appendicitis
D. Hyperthyroidism
🔴 RATIONALE: Infectious mononucleosis can cause splenomegaly, and splenic rupture is a rare but serious
complication requiring activity restriction.
. A patient with asthma uses albuterol several times daily and wakes at night with symptoms twice weekly. What
is the best next step in therapy?
A. Oral prednisone daily
B. 🟢 Inhaled corticosteroid
C. Theophylline monotherapy
D. Antibiotics
🔴 RATIONALE: Frequent rescue inhaler use and nocturnal symptoms indicate persistent asthma, which
requires controller therapy with an inhaled corticosteroid.
. A newborn has a systolic murmur and bounding pulses. Chest x-ray shows cardiomegaly with pulmonary
congestion. What defect is most likely?
A. Tetralogy of Fallot
B. Transposition of the great arteries
C. 🟢 Patent ductus arteriosus
D. Coarctation of the aorta
🔴 RATIONALE: Patent ductus arteriosus classically causes a continuous shunt and may present with
bounding pulses and signs of heart failure in newborns.
ANSWERS) PLUS RATIONALES 2026 Q&A |STUDY GUIDE| INSTANT DOWNLOAD PDF
CORE DOMAINS
Osteopathic principles and manipulative treatment.
Anatomy, physiology, and biochemistry.
Pathology and pathophysiology.
Pharmacology and microbiology.
Behavioral science and ethics.
Preventive medicine and public health.
Internal medicine and family medicine.
Pediatrics, obstetrics, and gynecology.
Surgery, emergency care, and clinical decision-making.
Systems-based practice and professionalism.*
INTRODUCTION
,This practice test is designed to assess foundational biomedical knowledge and clinical reasoning in a format
that mirrors the structure and demands of COMSAE Phase 1 preparation. It emphasizes multiple-choice, case-
based questions that require application of medical science, interpretation of clinical findings, and sound
decision-making. The exam assesses the integration of basic science, osteopathic principles, ethical practice,
and patient-centered care across common and high-yield clinical presentations. Questions are written to
reflect real-world medical scenarios and the judgment expected of future osteopathic physicians.
SECTION ONE
, . A 22-year-old college student develops sore throat, fever, and posterior cervical lymphadenopathy. He is
diagnosed with infectious mononucleosis. Which complication is most important to counsel him about?
A. 🟢 Splenic rupture
B. Otitis media
C. Appendicitis
D. Hyperthyroidism
🔴 RATIONALE: Infectious mononucleosis can cause splenomegaly, and splenic rupture is a rare but serious
complication requiring activity restriction.
. A patient with asthma uses albuterol several times daily and wakes at night with symptoms twice weekly. What
is the best next step in therapy?
A. Oral prednisone daily
B. 🟢 Inhaled corticosteroid
C. Theophylline monotherapy
D. Antibiotics
🔴 RATIONALE: Frequent rescue inhaler use and nocturnal symptoms indicate persistent asthma, which
requires controller therapy with an inhaled corticosteroid.
. A newborn has a systolic murmur and bounding pulses. Chest x-ray shows cardiomegaly with pulmonary
congestion. What defect is most likely?
A. Tetralogy of Fallot
B. Transposition of the great arteries
C. 🟢 Patent ductus arteriosus
D. Coarctation of the aorta
🔴 RATIONALE: Patent ductus arteriosus classically causes a continuous shunt and may present with
bounding pulses and signs of heart failure in newborns.
