BMSC 230 METABOLISM MODULES 9-13 QUESTIONS
AND VERIFIED ANSWERS
How many rounds of fatty acid synthesis are required to form palmitate? - Answers - 7
True or False?
Pentose phosphate pathway, and the transport of acetyl CoA in the form of citrate to the
cytosol from the mitochondria are the two sources of NADPH required for fatty acid
synthesis. - Answers - True
Which is the correct repetitive reaction sequence for fatty acid synthesis? - Answers -
Condensation, reduction, dehydration, reduction.
Which of the following statements about acetyl CoA carboxylase are true?
A) It has higher activity when it forms long filaments.
B) It is phosphorylated by protein kinase A.
C) Insulin stimulates its activity.
D) When it is phosphorylated it has lower activity.
E) It catalyzes the first committed step in fatty acid synthesis.
F) The product of the reaction it catalyzes is malonyl ACP. - Answers - A) C) D) E)
Fatty acids can be used for a variety of important biological functions. Which of the
below is NOT one of these?Can be used to supply carbons for ketone body synthesis.
A) Can be used to supply carbons for ketone body synthesis.
B)Can be used to supply carbons for glucose synthesis.
C) Are components of membranes.
D) Are precursors for signalling molecules. - Answers - B) Can be used to supply
carbons for glucose synthesis.
How does acetyl CoA get from the mitochondria to the cytosol so it can be used in fatty
acid synthesis?
A) It is directly transported by a specialized shuttle system.
B) It is converted to pyruvate which can cross the mitochondrial membrane.
C) It is converted to citrate which can be transported out to the cytosol where it is
broken down to oxaloacetate and acetyl CoA.
D) It is converted to malate which can shuttle between the cytosol and mitochondria. -
Answers - C) It is converted to citrate which can be transported out to the cytosol where
it is broken down to oxaloacetate and acetyl CoA.
Acyl carrier protein (ACP):
A) is an important component of the acetyl CoA carboxylase complex.
, B) acts as an arm which moves the intermediates of fatty acid synthesis from one
enzyme to the next.
C) contains biotin as a prosthetic group.
D) carries fatty acyl CoA molecules from the cell to the blood once they are synthesized.
- Answers - B) acts as an arm which moves the intermediates of fatty acid synthesis
from one enzyme to the next.
NADPH required for fatty acid synthesis come from:
A) the pyruvate dehydrogenase reaction
B) the citric acid cycle.
C) the process of transporting acetyl CoA to the cytosol.
D) Both a and c - Answers - C) the process of transporting acetyl CoA to the cytosol.
Production of a 19-carbon unsaturated fatty acid:
A) requires starting fatty acid synthesis with propionic acid.
B) requires specialized enzymes located in the cytoplasmic side of the golgi membrane.
C) can only occur if the double bond is located beyond carbon 9.
D) doesn't occur since only fatty acids with an even number of carbons are required. -
Answers - A) requires starting fatty acid synthesis with propionic acid.
Which statement about leukotrienes and prostaglandins is INCORRECT?
A) They are produced from arachidonate, an unsaturated fatty acid.
B) They are hormones that act on the same cells that produce them.
C) They have diverse functions in the cell.
D) Their synthesis is inhibited by aspirin. - Answers - D) Their synthesis is inhibited by
aspirin.
Which statement about the regulation of fatty acid synthesis is CORRECT?
A) Acetyl CoA carboxylase is the key enzyme in the pathway that is regulated.
B) Fatty acid synthesis is stimulated by a low energy state so that more fatty acids are
made that can be used as fuel.
C) Epinephrine stimulates fatty acid synthesis to provide fuel for the "fight or flight"
reflex.
D) Acetyl CoA carboxylase is phosphoryated by cAMP-dependent protein kinase and
inhibited allosterically by citrate. - Answers - A) Acetyl CoA carboxylase is the key
enzyme in the pathway that is regulated.
Which of the following is NOT a required ingredient for the synthesis of palmitate?
A) ATP
B) FADH2
C) NADPH
D) Acetyl CoA - Answers - B) FADH2
What do triacylglycerol and phospholipids have in common?
A) a, b, and c are all correct.
B) Both b and c are correct.
AND VERIFIED ANSWERS
How many rounds of fatty acid synthesis are required to form palmitate? - Answers - 7
True or False?
Pentose phosphate pathway, and the transport of acetyl CoA in the form of citrate to the
cytosol from the mitochondria are the two sources of NADPH required for fatty acid
synthesis. - Answers - True
Which is the correct repetitive reaction sequence for fatty acid synthesis? - Answers -
Condensation, reduction, dehydration, reduction.
Which of the following statements about acetyl CoA carboxylase are true?
A) It has higher activity when it forms long filaments.
B) It is phosphorylated by protein kinase A.
C) Insulin stimulates its activity.
D) When it is phosphorylated it has lower activity.
E) It catalyzes the first committed step in fatty acid synthesis.
F) The product of the reaction it catalyzes is malonyl ACP. - Answers - A) C) D) E)
Fatty acids can be used for a variety of important biological functions. Which of the
below is NOT one of these?Can be used to supply carbons for ketone body synthesis.
A) Can be used to supply carbons for ketone body synthesis.
B)Can be used to supply carbons for glucose synthesis.
C) Are components of membranes.
D) Are precursors for signalling molecules. - Answers - B) Can be used to supply
carbons for glucose synthesis.
How does acetyl CoA get from the mitochondria to the cytosol so it can be used in fatty
acid synthesis?
A) It is directly transported by a specialized shuttle system.
B) It is converted to pyruvate which can cross the mitochondrial membrane.
C) It is converted to citrate which can be transported out to the cytosol where it is
broken down to oxaloacetate and acetyl CoA.
D) It is converted to malate which can shuttle between the cytosol and mitochondria. -
Answers - C) It is converted to citrate which can be transported out to the cytosol where
it is broken down to oxaloacetate and acetyl CoA.
Acyl carrier protein (ACP):
A) is an important component of the acetyl CoA carboxylase complex.
, B) acts as an arm which moves the intermediates of fatty acid synthesis from one
enzyme to the next.
C) contains biotin as a prosthetic group.
D) carries fatty acyl CoA molecules from the cell to the blood once they are synthesized.
- Answers - B) acts as an arm which moves the intermediates of fatty acid synthesis
from one enzyme to the next.
NADPH required for fatty acid synthesis come from:
A) the pyruvate dehydrogenase reaction
B) the citric acid cycle.
C) the process of transporting acetyl CoA to the cytosol.
D) Both a and c - Answers - C) the process of transporting acetyl CoA to the cytosol.
Production of a 19-carbon unsaturated fatty acid:
A) requires starting fatty acid synthesis with propionic acid.
B) requires specialized enzymes located in the cytoplasmic side of the golgi membrane.
C) can only occur if the double bond is located beyond carbon 9.
D) doesn't occur since only fatty acids with an even number of carbons are required. -
Answers - A) requires starting fatty acid synthesis with propionic acid.
Which statement about leukotrienes and prostaglandins is INCORRECT?
A) They are produced from arachidonate, an unsaturated fatty acid.
B) They are hormones that act on the same cells that produce them.
C) They have diverse functions in the cell.
D) Their synthesis is inhibited by aspirin. - Answers - D) Their synthesis is inhibited by
aspirin.
Which statement about the regulation of fatty acid synthesis is CORRECT?
A) Acetyl CoA carboxylase is the key enzyme in the pathway that is regulated.
B) Fatty acid synthesis is stimulated by a low energy state so that more fatty acids are
made that can be used as fuel.
C) Epinephrine stimulates fatty acid synthesis to provide fuel for the "fight or flight"
reflex.
D) Acetyl CoA carboxylase is phosphoryated by cAMP-dependent protein kinase and
inhibited allosterically by citrate. - Answers - A) Acetyl CoA carboxylase is the key
enzyme in the pathway that is regulated.
Which of the following is NOT a required ingredient for the synthesis of palmitate?
A) ATP
B) FADH2
C) NADPH
D) Acetyl CoA - Answers - B) FADH2
What do triacylglycerol and phospholipids have in common?
A) a, b, and c are all correct.
B) Both b and c are correct.
