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Mn 553 Examination 2026 Verified Solution Compendium

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MN 553 EXAMINATION 2026 VERIFIED SOLUTION COMPENDIUM

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MN 553 EXAMINATION 2026 VERIFIED
SOLUTION COMPENDIUM


◉Clinical use for TCAs. Answer: Nocturnal enuresis


Intractable pain


Anxiety disorders.


◉Pharmacodynamics of TCAs. Answer: Act on neurotransmitters
serotonin and norepinephrine and histamine and acetylchoine


◉Pharmacokinetics of TCAs. Answer: Fairly long half life of 6-18
hours


Liver metabolism strong CYP2D6


◉What should the treatment for depression always include. Answer:
Referral for psychological therapy


◉Treatment for pediatric depression. Answer: Fluoxetine (Prozac)

,◉Why are MAOIs avoided. Answer: Low safety margin


Not a first line drug


Many drug-drug , food- drug interactions


◉SSRI pharmacodynamics. Answer: Selective inhibitory effects on
presynaptic serotonin reuptake


◉SSRI pharmacokinetics. Answer: Slow absorption


Half-life 26 hours


Extensive first pass metabolism


◉Fluoxetine half life. Answer: 1-3 days


◉Fluoxetine first metabolite. Answer: 4-16 days


◉SSRI ADRs. Answer: CNS

, GI


Sexual dysfunction


Serotonin syndrome


◉SSRI patient education. Answer: Pregnancy category B, C, or D


Withdrawal symptoms if abruptly discontinued


Avoid St. johns wort


◉SSRI monitoring. Answer: Never give more than 4 weeks on first
prescription


Monitor target symptoms


◉SNRI clinical uses. Answer: Major depressive disorder


GAD


Neuropathy

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