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Terms in this set (293)
What population is AML higher in? Males and in European Descent
What is a subtype of AML? APL
APL is more prevalent in.... Latino and Hispanics
What are the six groups of alkylating 1. Nitrogen Mustards
agents? 2. Etyhlenamine and methylenaimie deriatives.
3. Alkyl Sulfonates
4. Nitrosureas
5. Triazenes
6. Platinum Drugs
What are some drugs that are Cytoxan, Ifos
considered nitrogen mustards?
How do alkylating agents work? Act by inhibiting the transcription of DNA into RNA
and stops protein synthesis.
Alkylating agents work on... They work on all cells but work best on cells that
are rapidly dividing such as cancer cells.
, Alkylating agents also work on what Hematopoetic , reproductive and endothelial cells
other rapidly dividing cells... which accounts for SE such as anemia,
pancytopenia, amenorrhea, impaired
spermatogenesis, mucosal damage, alopecia and
increased risk of malignancy.
What are the major toxicities in the BM and GI Tract
alkylating agents?
What causes sinusoidal obstruction Alkylating Agents
syndrome?
What type of patients are at a higher WBC > 100,000
risk for TLS when presenting with
AML?
What is leukostasis? WBC > 100,000
What are 2 oncologic emergencies? Leukostasis and TLS
What is a common presentation with DIC with bleeding diathesis
APL?
Diagnosis of AML 1. Increased # of myeloblasts in BM and 2. 20%
blasts in marrow aspirate
When patients are on high dose Saline or steroid eye drops, until 24 hours after
cytarabine what should be done with completion of therapy.
their eyes?
MM is a tumor of old or young Old
adults?
Solutions | 2026 Edition | Pass Guaranteed
Save
Terms in this set (293)
What population is AML higher in? Males and in European Descent
What is a subtype of AML? APL
APL is more prevalent in.... Latino and Hispanics
What are the six groups of alkylating 1. Nitrogen Mustards
agents? 2. Etyhlenamine and methylenaimie deriatives.
3. Alkyl Sulfonates
4. Nitrosureas
5. Triazenes
6. Platinum Drugs
What are some drugs that are Cytoxan, Ifos
considered nitrogen mustards?
How do alkylating agents work? Act by inhibiting the transcription of DNA into RNA
and stops protein synthesis.
Alkylating agents work on... They work on all cells but work best on cells that
are rapidly dividing such as cancer cells.
, Alkylating agents also work on what Hematopoetic , reproductive and endothelial cells
other rapidly dividing cells... which accounts for SE such as anemia,
pancytopenia, amenorrhea, impaired
spermatogenesis, mucosal damage, alopecia and
increased risk of malignancy.
What are the major toxicities in the BM and GI Tract
alkylating agents?
What causes sinusoidal obstruction Alkylating Agents
syndrome?
What type of patients are at a higher WBC > 100,000
risk for TLS when presenting with
AML?
What is leukostasis? WBC > 100,000
What are 2 oncologic emergencies? Leukostasis and TLS
What is a common presentation with DIC with bleeding diathesis
APL?
Diagnosis of AML 1. Increased # of myeloblasts in BM and 2. 20%
blasts in marrow aspirate
When patients are on high dose Saline or steroid eye drops, until 24 hours after
cytarabine what should be done with completion of therapy.
their eyes?
MM is a tumor of old or young Old
adults?
