Updated Latest Test Bank For Pharmacotherapeutics For Advanced Practice Nurse Prescribers 6th Edition By Jill M Kolesar And Joseph T DiPiro Complete Questions And Answers Comprehensive Advanced Pharmacology Prescribing Drug Therapy Clinical Deci

PHARMACOTHERAPEUTICS FOR ADVANCED PRACTICE NURSE PRESCRIBERS,QUESTIONS & J J J J J J JJ




ANSWERS FULLY ANALYSED EDITION EXAM 100% CORRECTLY/VERIFIED ANSWERS WITH
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SATISFACTION GUARANTEED SUCCESS LATEST UPDATE 2023/2024 5TH EDITION WOO ROBINSON
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TEST BANK GRADED A+
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ANATASHIA
Chapter 1. J




AnIntroductiontoPharmacogenetics Multiple
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Choice
Identify the choice that best completes the statement or answers the question.
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J 1. Genetic polymorphisms account for differences in metabolism, including:
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1. Poor metabolizers, wholacka working enzyme J J J J J J




2. Intermediate metabolizers, who have one working, wild-type allele and one mutant J J J J J J J J J J




3. Extensive metabolizers, withtwo normally functioning alleles J J J J J J




4. All of the above J J J




J 2. Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to:
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1. A need to monitor drugs metabolized by 2D6 for toxicity
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2. Increased dosages needed of drugs metabolized by 2D6, suchas the J J J J J J J J J J JJ




selective serotoreuptake inhibitors J J




3. Decreased conversion of codeine tomorphine by CYP 2D6 J J J J J J J J




4. The need for lowered dosages of drugs, suchas beta blockers
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J 3. Rifampin is a nonspecific CYP450 inducer that may:
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1. Lead to toxic levels of rifampin and must be monitored closely
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2. Cause toxic levels of drugs, suchas oral contraceptives, whencoadministered
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3. Induce the metabolism of drugs, suchas oral contraceptives, leading totherapeutic
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4. Cause nonspecific changes indrug metabolism J J J J J




J 4. Inhibition of P-glycoprotein by a drug such as quinidine may lead to:
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1. Decreasedtherapeutic levels of quinidine J J J J




2. Increased therapeutic levels of quinidine J J J J




3. Decreased levels of a coadministered drug, suchas digoxin, that J J J J J J J J J J




requires P-glycoprabsorption and elimination J J J




4. Increased levels of a coadministered drug, such as digoxin, that J J J J J J J J J JJ




requires P-glycoproabsorption and elimination J J J




J 5. Warfarin resistance may be seen in patients with VCORC1 mutation, leading to:
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1. Toxic levels of warfarinbuilding up J J J J J

, 2. Decreased response to warfarin J J J




3. Increased riskfor significant drug interactions with warfarin
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4. Less riskof drug interactions with warfarin
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J 6. Genetic testing for VCORC1 mutation to assess potential warfarin
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resistance is requiredprior to prescribing warfarin.
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1. True
2. False

J 7. Pharmacogenetic testing is required by the U.S. Food and Drug
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Administration prior toprescribing: J J




1. Erythromycin
2. Digoxin
3. Cetuximab
4. Rifampin

J 8. Carbamazepine has a BlackBoxWarning recommending testing for the
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HLA-B*1502 allelein patients with Asian ancestry prior to starting
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therapy due to:
ATASHIA
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1. Decreased effectiveness of carbamazepine intreating seizures in Asian patients wit
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HLA-B*1502 allele J




2. Increased riskfor drug interactions in Asian patients with the HLA-B*1502 allele
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3. Increased riskfor Stevens-Johnson syndrome in Asianpatients with HLA-B*1502 a
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4. Patients who have the HLA-B*1502 allele being more likely to
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have a resistance tocarbamazepine
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J 9. Agenetic variationin how the metabolite of the cancer drug
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irinotecan SN-38 isinactivated by the body may lead to:
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1. Decreased effectiveness of irinotecanin the treatment of cancer J J J J J J J J




2. Increased adverse drug reactions, suchas neutropenia J J J J J J




3. Delayed metabolism of the prodrug irinotecanintothe active metabolite SN-38
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4. Increasedconcerns for irinotecanbeing carcinogenic J J J J J




10. Patients who have a poor metabolism phenotype will have:
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1. Slowed metabolism of a prodrug intoan active drug, leading toaccumulation of pr
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2. Accumulation of inactive metabolites of drugs J J J J J




3. A needfor increased dosages of medications
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4. Increased elimination of anactive drug J J J J J




11. Ultra-rapid metabolizers of drugs may have:
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, 1. To have dosages of drugs adjusted downward toprevent drug accumulation
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2. Active drug rapidly metabolized intoinactive metabolites, leading to
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potential therafailure J




3. Increasedelimination of active, nonmetabolized drug
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4. Slowed metabolism of a prodrug into anactive drug, leading to anaccumulation of
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12. A provider may consider testing for CYP2D6 variants prior to
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starting tamoxifen forbreast cancer to:
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1. Ensure the patient will not have increased adverse drug reactions to the tamoxifen
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2. Identify potential drug-drug interactions that may occur withtamoxifen
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3. Reduce the likelihood of therapeutic failure with tamoxifentreatment
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4. Identify poor metabolizers of tamoxifen
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, Chapter 1. An Introduction to
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PharmacogeneticsAnswerSection
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MULTIPLECHOICE J




1. ANS:
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J 2 PTS: 1
6. ANS:
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J 3 PTS: 1
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J 3 PTS: 1
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J 2 PTS: 1
10. 1 PTS: 1
ANS:
11. 2 PTS: 1
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12. 3 PTS: 1
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