RNSG 1301 REVIEW EXAMS ALL SET QUESTIONS
AND ANSWERS SURE A+
✔✔Which results are expected when arachidonic acid is metabolized through the
prostaglandin pathway?
Bronchospasms
Edema
Pain
Vasoconstriction
Vasopermeability - ✔✔Edema - Edema is an anticipated effect of the prostaglandin
pathway, specifically noting that bradykinin and histamine cause edema.
Pain - Pain is an anticipated effect of the prostaglandin pathway, specifically noting that
bradykinin and histamine cause pain.
Vasopermeability - Vasopermeability is an anticipated effect of arachidonic acid's
metabolism through the prostaglandin pathway.
✔✔Which defects may lead to hyperuricemia?
Delayed metabolism of uric acid
Enhanced elimination of uric acid
,Impaired absorption of uric acid
Overproduction of uric acid
Underexcretion of uric acid - ✔✔Overproduction of uric acid - Hyperuricemia is
generally the result of overproduction of uric acid, underexcretion of uric acid, or both.
Underexcretion of uric acid - Underexcretion of uric acid is a potential "defect" that may
lead to hyperuricemia.
✔✔Match the chemical class to the nonsteroidal antiinflammatory drug (NSAID) that
belongs to the class. - ✔✔Celecoxib - Cyclooxygenase-2 inhibitor
Ketorolac - Acetic acid derivative
Nabumetone - Enolic acid derivative
Ibuprofen - Propionic acid derivative
✔✔Which statements regarding nonsteroidal antiinflammatory drugs (NSAIDs) are
accurate?
Most NSAIDs inhibit both cyclooxygenase (COX)-1 and COX-2 to varying degrees.
Celecoxib inhibits both COX-1 and COX-2, which are involved in inflammation.
Ibuprofen selectively inhibits COX-1, which is the "bad" COX causing pain and
inflammation.
NSAIDs are also referred to as leukotriene inhibitors with antipyretic and analgesic
effects.
Although they possess antipyretic and analgesic effects, NSAIDs are mainly used for
antiinflammatory effects. - ✔✔Most NSAIDs inhibit both cyclooxygenase (COX)-1 and
COX-2 to varying degrees. - The majority of NSAIDs inhibit both COX-1 and COX-2 to
varying degrees. Celecoxib is the only COX-2 selective NSAID that is currently available
in the United States.
Although they possess antipyretic and analgesic effects, NSAIDs are mainly used for
antiinflammatory effects. - NSAIDs exert antiinflammatory, antipyretic, and analgesic
effects. The main use of NSAIDs is for their antiinflammatory effects.
✔✔Which statements regarding aspirin's pharmacokinetics are accurate?
Upon oral administration, aspirin is readily absorbed, with 80% to 100% of the drug
absorbed.
Rectal absorption of aspirin may be delayed if fecal material is present or blood supply
is reduced.
Aspirin distributes to all body fluids and tissues.
It is minimally (25%) protein bound in the body.
Aspirin undergoes deacetylation to salicylic acid.
Excretion is independent of urinary pH. - ✔✔Upon oral administration, aspirin is readily
absorbed, with 80% to 100% of the drug absorbed. - After oral administration, aspirin is
readily absorbed in the small intestines with 80% to 100% of the drug absorbed.
, Rectal absorption of aspirin may be delayed if fecal material is present or blood supply
is reduced. - The presence of fecal material and a reduced blood supply to the rectum
may delay absorption, resulting in a week or longer for the therapeutic effects to occur.
It is minimally (25%) protein bound in the body. - Aspirin is highly protein bound with
80% to 90% being bound.
Aspirin undergoes deacetylation to salicylic acid. - Aspirin's metabolism involves
deacetylation to salicylic acid. This undergoes glucuronidation, conjugation, and
oxidation.
✔✔Which statements describe the therapeutic uses of aspirin?
Closure of patent ductus arteriosus
Dysmenorrhea
Fever
Inflammation
Pain
Platelet aggregation inhibition - ✔✔Dysmenorrhea - Nonsteroidal antiinflammatory
drugs (NSAIDs) like aspirin may be useful in the treatment and relief of dysmenorrhea
by blocking prostaglandin synthesis in uterine smooth muscle.
Fever - Because of its antipyretic effects, aspirin may be useful in reducing fevers. It is
only effective against pyrogens, not other causes of fever, and aspirin should not be
used to manage fever in children because of a risk for Reye syndrome.
Inflammation - Aspirin and other NSAIDs are often used for their effects against
inflammation. When used to treat inflammation, aspirin is generally given in higher
doses compared with when it is used for fever and analgesia.
Pain - Aspirin may be used to treat mild to moderate pain, being most effective against
muscle pain, joint pain, and headache.
Platelet aggregation inhibition - Aspirin confers beneficial cardioprotective effects
against stroke and myocardial infarction through its ability to inhibit platelet aggregation.
✔✔Match the antigout drug with its associated mechanism of action. - ✔✔Inhibits
xanthine oxidase - Febuxostat
Inhibits chemotaxis and microtubule assembly - Colchicine
Blocks reabsorption and promotes excretion of uric acid - Probenecid
Inhibits uric acid transporter proteins required for uric acid reabsorption - Lesinurad
AND ANSWERS SURE A+
✔✔Which results are expected when arachidonic acid is metabolized through the
prostaglandin pathway?
Bronchospasms
Edema
Pain
Vasoconstriction
Vasopermeability - ✔✔Edema - Edema is an anticipated effect of the prostaglandin
pathway, specifically noting that bradykinin and histamine cause edema.
Pain - Pain is an anticipated effect of the prostaglandin pathway, specifically noting that
bradykinin and histamine cause pain.
Vasopermeability - Vasopermeability is an anticipated effect of arachidonic acid's
metabolism through the prostaglandin pathway.
✔✔Which defects may lead to hyperuricemia?
Delayed metabolism of uric acid
Enhanced elimination of uric acid
,Impaired absorption of uric acid
Overproduction of uric acid
Underexcretion of uric acid - ✔✔Overproduction of uric acid - Hyperuricemia is
generally the result of overproduction of uric acid, underexcretion of uric acid, or both.
Underexcretion of uric acid - Underexcretion of uric acid is a potential "defect" that may
lead to hyperuricemia.
✔✔Match the chemical class to the nonsteroidal antiinflammatory drug (NSAID) that
belongs to the class. - ✔✔Celecoxib - Cyclooxygenase-2 inhibitor
Ketorolac - Acetic acid derivative
Nabumetone - Enolic acid derivative
Ibuprofen - Propionic acid derivative
✔✔Which statements regarding nonsteroidal antiinflammatory drugs (NSAIDs) are
accurate?
Most NSAIDs inhibit both cyclooxygenase (COX)-1 and COX-2 to varying degrees.
Celecoxib inhibits both COX-1 and COX-2, which are involved in inflammation.
Ibuprofen selectively inhibits COX-1, which is the "bad" COX causing pain and
inflammation.
NSAIDs are also referred to as leukotriene inhibitors with antipyretic and analgesic
effects.
Although they possess antipyretic and analgesic effects, NSAIDs are mainly used for
antiinflammatory effects. - ✔✔Most NSAIDs inhibit both cyclooxygenase (COX)-1 and
COX-2 to varying degrees. - The majority of NSAIDs inhibit both COX-1 and COX-2 to
varying degrees. Celecoxib is the only COX-2 selective NSAID that is currently available
in the United States.
Although they possess antipyretic and analgesic effects, NSAIDs are mainly used for
antiinflammatory effects. - NSAIDs exert antiinflammatory, antipyretic, and analgesic
effects. The main use of NSAIDs is for their antiinflammatory effects.
✔✔Which statements regarding aspirin's pharmacokinetics are accurate?
Upon oral administration, aspirin is readily absorbed, with 80% to 100% of the drug
absorbed.
Rectal absorption of aspirin may be delayed if fecal material is present or blood supply
is reduced.
Aspirin distributes to all body fluids and tissues.
It is minimally (25%) protein bound in the body.
Aspirin undergoes deacetylation to salicylic acid.
Excretion is independent of urinary pH. - ✔✔Upon oral administration, aspirin is readily
absorbed, with 80% to 100% of the drug absorbed. - After oral administration, aspirin is
readily absorbed in the small intestines with 80% to 100% of the drug absorbed.
, Rectal absorption of aspirin may be delayed if fecal material is present or blood supply
is reduced. - The presence of fecal material and a reduced blood supply to the rectum
may delay absorption, resulting in a week or longer for the therapeutic effects to occur.
It is minimally (25%) protein bound in the body. - Aspirin is highly protein bound with
80% to 90% being bound.
Aspirin undergoes deacetylation to salicylic acid. - Aspirin's metabolism involves
deacetylation to salicylic acid. This undergoes glucuronidation, conjugation, and
oxidation.
✔✔Which statements describe the therapeutic uses of aspirin?
Closure of patent ductus arteriosus
Dysmenorrhea
Fever
Inflammation
Pain
Platelet aggregation inhibition - ✔✔Dysmenorrhea - Nonsteroidal antiinflammatory
drugs (NSAIDs) like aspirin may be useful in the treatment and relief of dysmenorrhea
by blocking prostaglandin synthesis in uterine smooth muscle.
Fever - Because of its antipyretic effects, aspirin may be useful in reducing fevers. It is
only effective against pyrogens, not other causes of fever, and aspirin should not be
used to manage fever in children because of a risk for Reye syndrome.
Inflammation - Aspirin and other NSAIDs are often used for their effects against
inflammation. When used to treat inflammation, aspirin is generally given in higher
doses compared with when it is used for fever and analgesia.
Pain - Aspirin may be used to treat mild to moderate pain, being most effective against
muscle pain, joint pain, and headache.
Platelet aggregation inhibition - Aspirin confers beneficial cardioprotective effects
against stroke and myocardial infarction through its ability to inhibit platelet aggregation.
✔✔Match the antigout drug with its associated mechanism of action. - ✔✔Inhibits
xanthine oxidase - Febuxostat
Inhibits chemotaxis and microtubule assembly - Colchicine
Blocks reabsorption and promotes excretion of uric acid - Probenecid
Inhibits uric acid transporter proteins required for uric acid reabsorption - Lesinurad
