Test bank for Tietz Fundamentals of Clinical Chemistry and
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Molecular Diagnostics,
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8th Edition by Nader Rifai, PhD
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Chapters 1 - 49p p p p
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
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Table of contents:
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I. Principles Of Laboratory Medicine
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Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
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Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
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Chapter 3. Clinical Evaluation of Methods
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Chapter 4. Evidence-Based Laboratory Medicine
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Chapter 5. Establishment and Use of Reference Values
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Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
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Chapter 7. Quality Management
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II. Analytical Techniques And Instrumentation
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Chapter 8. Principles of Basic Techniques and Laboratory Safety
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Chapter 9. Optical Techniques
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Chapter 10. Electrochemistry and Chemical Sensors
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Chapter 11. Electrophoresis
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Chapter 12. Chromatography
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Chapter 13. Mass Spectrometry
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Chapter 14. Enzyme and Rate Analyses
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Chapter 15. Immunochemical Techniques
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Chapter 16 Automationp p
Chapter 17. Point-of-Care Instrumentation
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III. Analytes
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Chapter 18. Amino Acids, Peptides, and Proteins
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Chapter 19. Serum Enzymes
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Chapter 20. Tumor Markers and Cancer Genes
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Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
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Chapter 22. Carbohydrates
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Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
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Chapter 24. Electrolytes and Blood Gases
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Chapter 25. Hormones p p
Chapter 26. Catecholamines and Serotonin
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Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
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Chapter 28. Hemoglobin, Iron, and Bilirubin
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Chapter 29. Porphyrins and Porphyrias
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Chapter 30. Therapeutic Drugs and Their Management
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Chapter 31. Clinical Toxicology
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Chapter 32. Toxic Metals
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IV. Pathophysiology
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Chapter 33. Diabetes p p
,Chapter 34. Cardiovascular Disease
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Chapter 35. Kidney Disease
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Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
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Chapter 37. Liver Disease
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Chapter 38. Gastrointestinal and Pancreatic Diseases
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Chapter 39. Disorders of Bone and Mineral Metabolism
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Chapter 40. Disorders of the Pituitary Gland
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Chapter 41. Disorders of the Adrenal Cortex
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Chapter 42. Thyroid Disorders
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Chapter 43. Reproduction-Related Disorders
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Chapter 44. Pregnancy and Prenatal Testing
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Chapter 45. Newborn Screening and Inborn Errors of Metabolism
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Chapter 46. Pharmacogenetics
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V. Molecular Diagnostics
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Chapter 47. Principles of Molecular Biology
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Chapter 48. Nucleic Acid Techniques and Applications
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Chapter 49. Genomes and Nucleic Acid Alterations
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, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine TestBank
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MULTIPLE CHOICE p
1. An individual working in a clinical chemistry laboratory is married to a sales representative
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who works for a company that sells chemistry laboratory supplies. When the laboratory
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manager requests a list of needed supplies, cost of supplies, and vendors, this individual only
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recommends the spouse’s company as the vendor. This is considered to be a(n):
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a. accounting issue. p
b. possible conflict of interest. p p p
c. maintenance of confidentiality issue. p p p
d. problem with resource allocation. p p p
ANS: B p
Concern has been raised over the interrelationships between practitioners in the medical
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fieldand commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
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Similarly, relationships have been scrutinized between clinical laboratorians and
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manufacturers and providers of diagnostic equipment and supplies. These concerns led the
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National Institutes of Health (NIH) in 1995 to require official institutional review of financial
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disclosure by researchers and management of situations in which disclosure indicates
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potentialconflicts of interest.
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DIF: 1 REF: Page 4-5 ppp p OBJ: 6 | 7 p p p
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce
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the pain following her recent surgery. A friend of the patient claims that the same painkiller
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“worked wonders” to reduce her pain after the same surgery. The physician states that the
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difference in the effect of the drug might be caused by
p p , which is studied in
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pharmacogenetics.
p
a. epidemiology
b. an inherited disease p p
c. a conflict of interest
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d. a genetic variation in drug-metabolizing enzymes
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ANS: D p
Pharmacogenetics is the study of the genetic variation of drug metabolism p p p p p p p p p p
betweenindividuals.
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DIF: 1 REF: Page 3 pp p p OBJ: 1 p
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
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name of a close friend printed on the bar-coded label. The genetic test that is ordered on
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thefriend’s sample would provide diagnostic information about a disorder that has a poor
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prognosis, and the test is usually performed by John. He asks a fellow employee to analyze
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the sample for him and not divulge the results. This ethical issue concerns:
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a. confidentiality of patient genetic and medical information. p p p p p p
b. a conflict of interest.
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c. resource allocation. p
d. diagnostic accuracy. p
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Molecular Diagnostics,
p p p
8th Edition by Nader Rifai, PhD
p p p p p p
Chapters 1 - 49p p p p
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
p p p p p p p p
p
p p
Table of contents:
p p
I. Principles Of Laboratory Medicine
p p p p
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
p p p p p p p p
Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
p p p p p p p p p p p
Chapter 3. Clinical Evaluation of Methods
p p p p p
Chapter 4. Evidence-Based Laboratory Medicine
p p p p
Chapter 5. Establishment and Use of Reference Values
p p p p p p p
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
p p p p p p p p
Chapter 7. Quality Management
p p p
II. Analytical Techniques And Instrumentation
p p p p
Chapter 8. Principles of Basic Techniques and Laboratory Safety
p p p p p p p p
Chapter 9. Optical Techniques
p p p
Chapter 10. Electrochemistry and Chemical Sensors
p p p p p
Chapter 11. Electrophoresis
p p
Chapter 12. Chromatography
p p
Chapter 13. Mass Spectrometry
p p p
Chapter 14. Enzyme and Rate Analyses
p p p p p
Chapter 15. Immunochemical Techniques
p p p
Chapter 16 Automationp p
Chapter 17. Point-of-Care Instrumentation
p p p
III. Analytes
p
Chapter 18. Amino Acids, Peptides, and Proteins
p p p p p p
Chapter 19. Serum Enzymes
p p p
Chapter 20. Tumor Markers and Cancer Genes
p p p p p p
Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
p p p p p p p p p p p
Chapter 22. Carbohydrates
p p
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
p p p p p p p p p
Chapter 24. Electrolytes and Blood Gases
p p p p p
Chapter 25. Hormones p p
Chapter 26. Catecholamines and Serotonin
p p p p
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
p p p p p p
Chapter 28. Hemoglobin, Iron, and Bilirubin
p p p p p
Chapter 29. Porphyrins and Porphyrias
p p p p
Chapter 30. Therapeutic Drugs and Their Management
p p p p p p
Chapter 31. Clinical Toxicology
p p p
Chapter 32. Toxic Metals
p p p
IV. Pathophysiology
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Chapter 33. Diabetes p p
,Chapter 34. Cardiovascular Disease
p p p
Chapter 35. Kidney Disease
p p p
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
p p p p p p p p p p
Chapter 37. Liver Disease
p pp p
Chapter 38. Gastrointestinal and Pancreatic Diseases
p p p p p
Chapter 39. Disorders of Bone and Mineral Metabolism
p pp p p p p p
Chapter 40. Disorders of the Pituitary Gland
p pp p p p p
Chapter 41. Disorders of the Adrenal Cortex
p p p p p p
Chapter 42. Thyroid Disorders
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Chapter 43. Reproduction-Related Disorders
p p p
Chapter 44. Pregnancy and Prenatal Testing
p pp p p p
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
p p p p p p p p
Chapter 46. Pharmacogenetics
p p
V. Molecular Diagnostics
p p
Chapter 47. Principles of Molecular Biology
p p p p p
Chapter 48. Nucleic Acid Techniques and Applications
p p p p p p
Chapter 49. Genomes and Nucleic Acid Alterations
p p p p p p
, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine TestBank
p p p p p p p p p p
MULTIPLE CHOICE p
1. An individual working in a clinical chemistry laboratory is married to a sales representative
p p p p p p p p p p p p p
who works for a company that sells chemistry laboratory supplies. When the laboratory
p p p p p p p p p p p p p
manager requests a list of needed supplies, cost of supplies, and vendors, this individual only
p p p p p p p p p p p p p p p
recommends the spouse’s company as the vendor. This is considered to be a(n):
p p p p p p p p p p p p p
a. accounting issue. p
b. possible conflict of interest. p p p
c. maintenance of confidentiality issue. p p p
d. problem with resource allocation. p p p
ANS: B p
Concern has been raised over the interrelationships between practitioners in the medical
p p p p p p p p p p p
fieldand commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
p p p p p p p p p p p p p
Similarly, relationships have been scrutinized between clinical laboratorians and
p p p p p p p p
manufacturers and providers of diagnostic equipment and supplies. These concerns led the
p p p p p p p p p p p p
National Institutes of Health (NIH) in 1995 to require official institutional review of financial
p p p p p p p p p p p p p p
disclosure by researchers and management of situations in which disclosure indicates
p p p p p p p p p p p
potentialconflicts of interest.
p p p p
DIF: 1 REF: Page 4-5 ppp p OBJ: 6 | 7 p p p
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce
p p p p p p p p p p p p p p
the pain following her recent surgery. A friend of the patient claims that the same painkiller
p p p p p p p p p p p p p p p p
“worked wonders” to reduce her pain after the same surgery. The physician states that the
p p p p p p p p p p p p p p p
difference in the effect of the drug might be caused by
p p , which is studied in
p p p p p p p p p p p p p
pharmacogenetics.
p
a. epidemiology
b. an inherited disease p p
c. a conflict of interest
p p p
d. a genetic variation in drug-metabolizing enzymes
p p p p p
ANS: D p
Pharmacogenetics is the study of the genetic variation of drug metabolism p p p p p p p p p p
betweenindividuals.
p p
DIF: 1 REF: Page 3 pp p p OBJ: 1 p
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
p p p p p p p p p p p p p p
name of a close friend printed on the bar-coded label. The genetic test that is ordered on
p p p p p p p p p p p p p p p p p
thefriend’s sample would provide diagnostic information about a disorder that has a poor
p p p p p p p p p p p p p p
prognosis, and the test is usually performed by John. He asks a fellow employee to analyze
p p p p p p p p p p p p p p p p
the sample for him and not divulge the results. This ethical issue concerns:
p p p p p p p p p p p p p
a. confidentiality of patient genetic and medical information. p p p p p p
b. a conflict of interest.
p p p
c. resource allocation. p
d. diagnostic accuracy. p
