Gold Compounds
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Auranofin (po)
-Inhibits release of lysosomes that cause destruction & inhibits
phagocytosis
-Quite toxic
-Contraindicated with many diseases
Salicylates
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Aspirin (po)
, -Inhibits prostaglandin synthesis and TXA2
-Salicylism toxicity 20g for adults, 4g for children
Antimetabolites
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Methotrexate (IV, PO)
-Inhibit DNA synthesis by blocking thymidylate, DNA polymerase, or folic
acid reductase
-In S phase of cell cycle
-Used in rapidly dividing cancers
Methotrexate crosses BBB
Leucovorin is given to counter adverse effects
Anti-neoplastic Antibiotics
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Doxorubicin (IV)
-Breaks DNA strands in G2/M phase
-For rapidly dividing cancers
-ALL parenterally
-Doxo&Daunorubicin are both taken up by heart/lungs so can be toxic
-Dexrazoxane is given as cardioprotective drug
Protein C & Antithrombin
Give this one a try later!
Give this one a try later!
Auranofin (po)
-Inhibits release of lysosomes that cause destruction & inhibits
phagocytosis
-Quite toxic
-Contraindicated with many diseases
Salicylates
Give this one a try later!
Aspirin (po)
, -Inhibits prostaglandin synthesis and TXA2
-Salicylism toxicity 20g for adults, 4g for children
Antimetabolites
Give this one a try later!
Methotrexate (IV, PO)
-Inhibit DNA synthesis by blocking thymidylate, DNA polymerase, or folic
acid reductase
-In S phase of cell cycle
-Used in rapidly dividing cancers
Methotrexate crosses BBB
Leucovorin is given to counter adverse effects
Anti-neoplastic Antibiotics
Give this one a try later!
Doxorubicin (IV)
-Breaks DNA strands in G2/M phase
-For rapidly dividing cancers
-ALL parenterally
-Doxo&Daunorubicin are both taken up by heart/lungs so can be toxic
-Dexrazoxane is given as cardioprotective drug
Protein C & Antithrombin
Give this one a try later!
