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Sixth edition
Copyright © 2024 Wolters Kluwer.
Copyright © 2020 Wolters Kluwer. Copyright © 2016 Wolters Kluwer. Copyright
© 2013, 2009 Wolters Kluwer Health / Lippincott Williams & Wilkins. Copyright
© 2005 All rights reserved. This book is protected by copyright. No part of this
book may be reproduced or transmitted in any form or by any means, including
as photocopies or scanned-in or other electronic copies, or utilized by any
information storage and retrieval system without written permission from the
copyright owner, except for brief quotations embodied in critical articles and
reviews. Materials appearing in this book prepared by individuals as part of their
oûcial duties as U.S. government employees are not covered by the above-
mentioned copyright. To request permission, please contact Wolters Kluwer at
Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at
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9 8 7 6 5 4 3 2 1
Printed in Mexico
Library of Congress Cataloging-in-Publication Data available upon request.
978-1-975192-74-7
This work is provided “as is,” and the publisher disclaims any and all warranties,
express or implied, including any warranties as to accuracy, comprehensiveness,
or currency of the content of this work.
This work is no substitute for individual patient assessment based upon
healthcare professionals’ examination of each patient and consideration of, among
other things, age, weight, gender, current or prior medical conditions, medication
history, laboratory data and other factors unique to the patient. The publisher
does not provide medical advice or guidance and this work is merely a reference
tool. Healthcare professionals, and not the publisher, are solely responsible for the
, use of this work including all medical judgments and for any resulting diagnosis
and treatments.
Given continuous, rapid advances in medical science and health information,
independent professional veriûcation of medical diagnoses, indications,
appropriate pharmaceutical selections and dosages, and treatment options should
be made and healthcare professionals should consult a variety of sources. When
prescribing medication, healthcare professionals are advised to consult the
product information sheet (the manufacturer’s package insert) accompanying
each drug to verify, among other things, conditions of use, warnings and side
effects and identify any changes in dosage schedule or contraindications,
particularly if the medication to be administered is new, infrequently used or has
a narrow therapeutic range. To the maximum extent permitted under applicable
law, no responsibility is assumed by the publisher for any injury and/or damage
to persons or property, as a matter of products liability, negligence law or
otherwise, or from any reference to or use by any person of this work
shop.lww.com
,Not authorised for sale in United States, Canada, Australia, New Zealand,
Puerto Rico, and U.S. Virgin Islands.
Acquisitions Editor: Matt Hauber
Senior Development Editor: Amy Millholen
Editorial Coordinator: Erin E. Hernandez
Editorial Assistant: Parisa Saranj
Marketing Manager: Phyllis Hitner
Production Project Manager: Matt West
Manager, Graphic Arts & Design: Steve Druding
Manufacturing Coordinator: Margie Orzech-Zeranko
Prepress Vendor: Aptara, Inc.
Sixth edition
Copyright © 2024 Wolters Kluwer.
Copyright © 2020 Wolters Kluwer. Copyright © 2016 Wolters Kluwer. Copyright
© 2013, 2009 Wolters Kluwer Health / Lippincott Williams & Wilkins. Copyright
© 2005 All rights reserved. This book is protected by copyright. No part of this
book may be reproduced or transmitted in any form or by any means, including
as photocopies or scanned-in or other electronic copies, or utilized by any
information storage and retrieval system without written permission from the
copyright owner, except for brief quotations embodied in critical articles and
reviews. Materials appearing in this book prepared by individuals as part of their
oûcial duties as U.S. government employees are not covered by the above-
mentioned copyright. To request permission, please contact Wolters Kluwer at
Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at
, or via our website at shop.lww.com (products and
services).
9 8 7 6 5 4 3 2 1
Printed in Mexico
Library of Congress Cataloging-in-Publication Data available upon request.
978-1-975192-74-7
This work is provided “as is,” and the publisher disclaims any and all warranties,
express or implied, including any warranties as to accuracy, comprehensiveness,
or currency of the content of this work.
This work is no substitute for individual patient assessment based upon
healthcare professionals’ examination of each patient and consideration of, among
other things, age, weight, gender, current or prior medical conditions, medication
history, laboratory data and other factors unique to the patient. The publisher
does not provide medical advice or guidance and this work is merely a reference
tool. Healthcare professionals, and not the publisher, are solely responsible for the
, use of this work including all medical judgments and for any resulting diagnosis
and treatments.
Given continuous, rapid advances in medical science and health information,
independent professional veriûcation of medical diagnoses, indications,
appropriate pharmaceutical selections and dosages, and treatment options should
be made and healthcare professionals should consult a variety of sources. When
prescribing medication, healthcare professionals are advised to consult the
product information sheet (the manufacturer’s package insert) accompanying
each drug to verify, among other things, conditions of use, warnings and side
effects and identify any changes in dosage schedule or contraindications,
particularly if the medication to be administered is new, infrequently used or has
a narrow therapeutic range. To the maximum extent permitted under applicable
law, no responsibility is assumed by the publisher for any injury and/or damage
to persons or property, as a matter of products liability, negligence law or
otherwise, or from any reference to or use by any person of this work
shop.lww.com
