Top 300 Quiz #4 Question and answers 100% correct
2025/2026
1.Atezolizumab Brand: Tecentriq
Class: mAb; Inhibits PD-L1 (receptor on tumor cell) -->
Prevents inactivation of T-cells
Indication(s): Bladder + Lung Cancers
ADEs: fatigue, lost appetite, nausea, UTI's/infections
2. Bleomycin Brand: Blenoxane
Class: Antracycline (Top II) --> ss + dsDNA breaks following free radical
formation Indication(s): Antitumor antibiotic; One of most widely used
anti-cancer agents DLTs: Pulmonary fibrosis (lifetime max dose <400
units); NOT myelosuppressive!! Clinical Pearls:
Routes of admin --> IV, SubCut, IM
3. Capecitabine Brand: Xeloda
Class: Thymidylate synthase (TS) inhibitor; Prodrug of 5-FU
Indication(s): Colon + Colorectal cancer (first line and in advanced,
metastatic cases)
DLTs: Diarrhea, hand and foot syndrome, decrease in 'other' GI toxicities
seen with 5-FU
Clinical Pearls:
Liver activation 1st, then Hydrolyzed to 5-FU by thymidine phophorylase (TP)
4. Carboplatin Brand: Paraplatin
Class: Platinum --> binds guanine + forms cross links to inhibit DNA
synthesis + function
Indication(s): Lung + Reproductive cancers
ADEs: Nephrotoxic, peripheral neuropathy, ototoxicity, and many traditional
chemo adverse ettects
DLTs: Myelosuppression
Clinical Pearls:
- Decreased renal and GI toxicity; overall more tolerable
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, Top 300 Quiz #4
5. Cisplatin Brand: Platinol
Class: Platinum --> binds guanine + forms cross links to inhibit DNA
synthesis + function
Indication(s): Lung + Reproductive cancers
ADEs: Nephrotoxic, peripheral neuropathy, ototoxicity, and many traditional
chemo adverse ettects
Clinical Pearls:
- Renal dysfunction requires dose modification
6. Cyclopho Brand: Cytoxen
s- Class: Alkylating agent --> Addition of alkyl groups to DNA --> DNA
phamide strand break-age
Indication(s): Nonspecific cancers
ADEs: Myelosuppression, GI issues, reproductive abnormalities, and
increased risk of secondary malignancies
Important Info:
-Prodrug
-Nonenzymatic cleavage in tumor and normal tissue --> acrolein
and mustard (active species) --> Cytotoxic
7. Docetaxel Brand: Taxotere
Class: Taxane --> Mitotic spindle poison --> Stabilizes tubulin formation/blocks
depolymerization.
Indication(s): Second line --> Advanced breast, lung, platinum refractory GU
ADEs: Nephrotoxic, peripheral neuropathy, ototoxicity, and many traditional
chemo adverse ettects
DLTs: Myelosuppression with neutropenia, neurotoxicity, fluid retention
Clinical Pearls:
- Semi-synthetic derivative of paclitaxel
8. Doxorubicin Brand: Adriamycin
Class: Antracycline (Top II) --> ss + dsDNA breaks following free radical
formation
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2025/2026
1.Atezolizumab Brand: Tecentriq
Class: mAb; Inhibits PD-L1 (receptor on tumor cell) -->
Prevents inactivation of T-cells
Indication(s): Bladder + Lung Cancers
ADEs: fatigue, lost appetite, nausea, UTI's/infections
2. Bleomycin Brand: Blenoxane
Class: Antracycline (Top II) --> ss + dsDNA breaks following free radical
formation Indication(s): Antitumor antibiotic; One of most widely used
anti-cancer agents DLTs: Pulmonary fibrosis (lifetime max dose <400
units); NOT myelosuppressive!! Clinical Pearls:
Routes of admin --> IV, SubCut, IM
3. Capecitabine Brand: Xeloda
Class: Thymidylate synthase (TS) inhibitor; Prodrug of 5-FU
Indication(s): Colon + Colorectal cancer (first line and in advanced,
metastatic cases)
DLTs: Diarrhea, hand and foot syndrome, decrease in 'other' GI toxicities
seen with 5-FU
Clinical Pearls:
Liver activation 1st, then Hydrolyzed to 5-FU by thymidine phophorylase (TP)
4. Carboplatin Brand: Paraplatin
Class: Platinum --> binds guanine + forms cross links to inhibit DNA
synthesis + function
Indication(s): Lung + Reproductive cancers
ADEs: Nephrotoxic, peripheral neuropathy, ototoxicity, and many traditional
chemo adverse ettects
DLTs: Myelosuppression
Clinical Pearls:
- Decreased renal and GI toxicity; overall more tolerable
1/
7
, Top 300 Quiz #4
5. Cisplatin Brand: Platinol
Class: Platinum --> binds guanine + forms cross links to inhibit DNA
synthesis + function
Indication(s): Lung + Reproductive cancers
ADEs: Nephrotoxic, peripheral neuropathy, ototoxicity, and many traditional
chemo adverse ettects
Clinical Pearls:
- Renal dysfunction requires dose modification
6. Cyclopho Brand: Cytoxen
s- Class: Alkylating agent --> Addition of alkyl groups to DNA --> DNA
phamide strand break-age
Indication(s): Nonspecific cancers
ADEs: Myelosuppression, GI issues, reproductive abnormalities, and
increased risk of secondary malignancies
Important Info:
-Prodrug
-Nonenzymatic cleavage in tumor and normal tissue --> acrolein
and mustard (active species) --> Cytotoxic
7. Docetaxel Brand: Taxotere
Class: Taxane --> Mitotic spindle poison --> Stabilizes tubulin formation/blocks
depolymerization.
Indication(s): Second line --> Advanced breast, lung, platinum refractory GU
ADEs: Nephrotoxic, peripheral neuropathy, ototoxicity, and many traditional
chemo adverse ettects
DLTs: Myelosuppression with neutropenia, neurotoxicity, fluid retention
Clinical Pearls:
- Semi-synthetic derivative of paclitaxel
8. Doxorubicin Brand: Adriamycin
Class: Antracycline (Top II) --> ss + dsDNA breaks following free radical
formation
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7
