Top 300 Quiz #3 Questions with complete solution
2025/2026
1. Aprepitant Brand: Emend
Class: Neurokinin 1 (NK1) Receptor
Antagonist Indication: N/V
ADME: CYP3A4 substrate and inhibitor, CYP2C9 inducer
DDIs: May increase conc. of chemotherapy medications, risk for
decreased ettec-tiveness of estrogen-containing contraceptives, and can
decrease INR when given with warfarin therapy
Key patient counseling: In combination with other antiemetics in CINV and
PONV
2. Bisacodyl Brand: Dulcolax
Class: Stimulant Laxative
Indication: Constipation --> reserved after failure to bulk forming and osmotic
laxatives
ADME: Deacetylation in colon; UGT glucuronidation
Warning/precaution: Not recommended for use in patients
experiencing stomach pain, nausea, vomiting, or a sudden change in
bowel movements with lasts > 2 weeks
GI side ettects: Abdominal cramping, pain, discomfort
3. Chlorpromazine Brand: Thorazine
Class: Dopamine Antagonists
Indication: N/V --> primarily used as rescue antiemetics for PONV
AEs: Extrapyramidal symptoms (EPS) --> Avoid chronic use (>12
weeks), QTc pro-longation --> dysrhythmias --> Torsades de Pointes,
Sedation, Hypotension
Key patient counseling: Not first-line agents for N/V due to side ettects of
sedation, orthostatic hypotension, and extrapyramidal symptoms
4. Dimenhydrinate Brand: Dramamine
Class: Antihistamine/Antimuscarinic, H1R antagonist
Indication: N/V --> primary use is for prevention of N/V associated with
,vertigo & motion sickness
ADME: CYP2D6 substrate & inhibitor
, Top 300 Quiz #3
AEs: Anti-cholingeric related: sedation/drowsiness/confusion -->
caution/avoid in the older adults, dry mouth, blurry vision -->
problematic in patients w/ narrow angle glaucoma, urinary retention -->
caution/avoid in patient w/ BPH, tachycardia
5. Diphenoxy- Brand: Lomotil
late/
Class: Antimotility agent (Opiates)
atropine
Indication: Acute & chronic diarrhea
ADME: Esterase substrate --> cleavage to difenoxin
AEs: Constipation, cramps, nausea, dizziness, respiratory depression,
confusion, euphoria
Key patient counseling:
Diphenoxylate is co-formulated with atropine to discourage abuse -->
anticholin-ergic ettects if taken in large doses (e.g., blurred vision, dry
mouth, sedation, constipation, and urinary retention)
6. Docusate sodium Brand: Colace
Class: Emollient/Stool softener
Indication: Prevention of constipation, useful when straining should be
avoided, often combined with stimulant laxative induced constipation
AEs: Diarrhea, cramps, throat irritation
7. Doxylamine Brand: Unisom
Class: Antihistamine --> H1R Antagonists
Indication: N/V --> treatment of vertigo or motion
sickness ADME: CYP2D6 substrate
AEs: Anti-cholingeric related: sedation/drowsiness/confusion -->
caution/avoid in the older adults, dry mouth, blurry vision -->
problematic in patients w/ narrow angle glaucoma, urinary retention -->
caution/avoid in patient w/ BPH, tachycardia
8. Dronabinol Brand: Marinol
Controlled substance:
2025/2026
1. Aprepitant Brand: Emend
Class: Neurokinin 1 (NK1) Receptor
Antagonist Indication: N/V
ADME: CYP3A4 substrate and inhibitor, CYP2C9 inducer
DDIs: May increase conc. of chemotherapy medications, risk for
decreased ettec-tiveness of estrogen-containing contraceptives, and can
decrease INR when given with warfarin therapy
Key patient counseling: In combination with other antiemetics in CINV and
PONV
2. Bisacodyl Brand: Dulcolax
Class: Stimulant Laxative
Indication: Constipation --> reserved after failure to bulk forming and osmotic
laxatives
ADME: Deacetylation in colon; UGT glucuronidation
Warning/precaution: Not recommended for use in patients
experiencing stomach pain, nausea, vomiting, or a sudden change in
bowel movements with lasts > 2 weeks
GI side ettects: Abdominal cramping, pain, discomfort
3. Chlorpromazine Brand: Thorazine
Class: Dopamine Antagonists
Indication: N/V --> primarily used as rescue antiemetics for PONV
AEs: Extrapyramidal symptoms (EPS) --> Avoid chronic use (>12
weeks), QTc pro-longation --> dysrhythmias --> Torsades de Pointes,
Sedation, Hypotension
Key patient counseling: Not first-line agents for N/V due to side ettects of
sedation, orthostatic hypotension, and extrapyramidal symptoms
4. Dimenhydrinate Brand: Dramamine
Class: Antihistamine/Antimuscarinic, H1R antagonist
Indication: N/V --> primary use is for prevention of N/V associated with
,vertigo & motion sickness
ADME: CYP2D6 substrate & inhibitor
, Top 300 Quiz #3
AEs: Anti-cholingeric related: sedation/drowsiness/confusion -->
caution/avoid in the older adults, dry mouth, blurry vision -->
problematic in patients w/ narrow angle glaucoma, urinary retention -->
caution/avoid in patient w/ BPH, tachycardia
5. Diphenoxy- Brand: Lomotil
late/
Class: Antimotility agent (Opiates)
atropine
Indication: Acute & chronic diarrhea
ADME: Esterase substrate --> cleavage to difenoxin
AEs: Constipation, cramps, nausea, dizziness, respiratory depression,
confusion, euphoria
Key patient counseling:
Diphenoxylate is co-formulated with atropine to discourage abuse -->
anticholin-ergic ettects if taken in large doses (e.g., blurred vision, dry
mouth, sedation, constipation, and urinary retention)
6. Docusate sodium Brand: Colace
Class: Emollient/Stool softener
Indication: Prevention of constipation, useful when straining should be
avoided, often combined with stimulant laxative induced constipation
AEs: Diarrhea, cramps, throat irritation
7. Doxylamine Brand: Unisom
Class: Antihistamine --> H1R Antagonists
Indication: N/V --> treatment of vertigo or motion
sickness ADME: CYP2D6 substrate
AEs: Anti-cholingeric related: sedation/drowsiness/confusion -->
caution/avoid in the older adults, dry mouth, blurry vision -->
problematic in patients w/ narrow angle glaucoma, urinary retention -->
caution/avoid in patient w/ BPH, tachycardia
8. Dronabinol Brand: Marinol
Controlled substance:
