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CPJE 2026 Practice Exam | Realistic Questions & Answers New Update

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This compilation covers critical drug warnings, genetic screening (HLA-B*1502 in Asians before carbamazepine; HLA-B*5701 before abacavir), opioid alternatives without crossreactivity (fentanyl, methadone), and key drug interactions (inducers like PS PORCS; inhibitors like GPACMAN). It details diabetes medications (glipizide before meals; repaglinide; canagliflozin; liraglutide), cardiovascular drugs (amiodarone precautions; DOACs; beta-blockers for HF; BiDil in AA), respiratory agents (salmeterol with steroid; omalizumab in-office; tiotropium), psychiatry drugs (MAOIs; bupropion; antipsychotics with EPS or metabolic effects), Parkinson’s drugs (pramipexole; apomorphine; amantadine), Alzheimer’s agents (memantine; rivastigmine; donepezil), anticoagulants (argatroban in HIT; dabigatran; apixaban; rivaroxaban; fondaparinux), antiarrhythmics (amiodarone; dronedarone; dofetilide requiring in-hospital start), chemotherapy safety (doxorubicin cardiotoxicity; capecitabine hand-foot syndrome; tamoxifen DVT risk), diuretics (ethacrynic acid ototoxicity; metolazone in renal impairment), ophthalmology (dorzolamide sulfa allergy), dermatology (tacrolimus; ivermectin for scabies), osteoporosis (teriparatide requiring calcium), and safety warnings (propofol avoid in egg/soy allergy; phenytoin side effects; leaching requirements for amiodarone and certain cancer drugs).

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CPJE 2026 Practice Exam | Realistic
Questions & Answers New Update
1. Rotigotine - >>>>>> Neupro patch: do not heat/ use during MRI



2. HLA b1502 - >>>>>> Test in Asians. Rash for carbamazepine (tegretol), phenytoin (Dilantin), fos
phenytoin (cerebyx)



3. Trastuzumab - >>>>>> Herceptin, her/Neu- ado-trastuzunab (kadcyla), lapatinib (tykerb) pertuzumab
(perjeta)



4. Hla- b 5701 - >>>>>> Don't give abacavir (ziagen), epzicom, trizivir



5. Not cross reactive a/ opioid allergy - >>>>>> Fentanyl, meperidine (Demerol), methadone
(dolophine), tramadol (ultram), tapentadol (nucynta)



6. Inducers - >>>>>> Ps porcs (phenytoin, smoking, phenobarbital, oxcarbazepine, rifampin,
carbamazepine, St. John's wort)



7. Inhibitors - >>>>>> Gpacman (grapefruit, pi's, azoles, cimetidine/cyclosporine, macrolides-
erytho/clarithro, amiodarone, non dihydro (dilt, verapamil))



8. If on amiodarone, decrease these drugs by 30-50% - >>>>>> Digoxin, warfarin, quinidine,
procainanide, statins



9. Statins with high risk of inhibition - >>>>>> Las (lova, atorva, simva)



10. Entecavir - >>>>>> Baraclude. Empty stomach for hep B that fail lamivudime and adefovir- se:
peripheral edema, nephrotoxic

,11. Ribavirin - >>>>>> Copegus. W/ food bid for hep c, hepatotoxic, hemolytic anemia, preg x, psych
disorders, ci: renal disfxn



12. Glipizide - >>>>>> Glucotrol 30 min before break & dinner



13. Glimeprimide - >>>>>> Amaryl 1-2 mg qd w/ 1st meal



14. Glyburide - >>>>>> Diabeta, + metformin = glucovance, do not use w/ renal failure 2.5-5mg qd



15. Rosiglitazone - >>>>>> Avandia 4-8mg qd (tzd, exacerbate hf, liver damage, increases hdl, decreases
tg/total cholesterol) similar: pioglitazone (actos)



16. Repaglinide - >>>>>> Prandin 0.5-2mg TID 15-30 min before a meal, hypoglycemia- do not take with
su's



17. Nateglinide - >>>>>> Starlix injection- 15-30 min before meals



18. Acarbose - >>>>>> Precose- w/ 1st bite of meal and water



19. Miglitol - >>>>>> Glyset w/ 1st bite of meal and water



20. Linagliptan - >>>>>> Tradjenta- 5 mg qd in morning with or without food, no renal adjustment



21. Saxagliptin - >>>>>> OnglyZa 2.5-5mg qd



22. Canaglifozin - >>>>>> Invokana 100mg qd before first meal of day for DM. Se: female genital mycotic
infxn, increased urination, hyperkalemia, can increase dig levels, ci: renal dx

, 23. Exenatide - >>>>>> Byetta 30-60 min before am & pm meals, medguide, pancreatitis, thyroid c-cell
carcinoma xr= bydureon



24. Liraglutide - >>>>>> Victoza QD thyroid c-cell carcinoma, more weight loss, less pancreatitis



25. Pramlintide - >>>>>> Symlin - injection, skip if no meals, weight loss



26. Insulin aspart - >>>>>> Novolog rapid



27. Insulin glulisine - >>>>>> Apidra rapid



28. Insulin lispro - >>>>>> Humalog rapid



29. Detemir - >>>>>> Levemir long acting



30. Insulin glargine - >>>>>> Lantus long acting



31. Ibandronate - >>>>>> Boniva 150 monthly



32. Zolendrenic acid - >>>>>> Reclast iv - pretreat w/nsaids



33. Teriparatide - >>>>>> Forteo SC daily: osteosarcoma, kidney stones, orthostatic hypotension,
hypocalcemia- must take ca starting 2 weeks before time- fridge after each dose, sit while giving



34. Lotensin - >>>>>> Benazepril



35. Indapamide - >>>>>> Lozol 1.25-5mg- thiazide diuretic



36. Aerobid - >>>>>> Budesonide inhaler

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