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Samenvatting Universiteit Gent | Biochemie | H2: Glycolyse | 2025/26

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In dit document wordt H2 van biochemie (metabolisme) behandeld. De glycolyse wordt stap voor stap duidelijk uitgelegd met de chemische formules erbij getekend. Dit document bevat ook alle informatie die in de hoorcolleges werden meegegeven door Dr. Prof K. De Bosscher. Via deze samenvatting/notitie is een moeilijk onderwerp zoals glycolyse eenvoudig te begrijpen.

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H2: de glycolyse
Glucose + 2 ADP + 2 NAD* + 2 Pi

2 1
.
van glucose naar pyruaat
glycolyse :
glucose >
-
pyruvaat 110 stappen)
Chexose) Carbonzuur)
2 pyruvaat + 2ATP + 2 NADH + 2H + + 2H2O
↳3 C- atomen

Carbonylgroep
↳ hydroxyl groep
in 10 enzymatische reacties

PyrUVAE actyl Coa
oxidatieve
decarboxylatie INVESTERINGS-SPUTSINGS-WINSTFASE
FASE FASE

productie NADH moleculen ISTAP 1-3) ISTAP4-5) ISTAP 6-10)




glucose >
- bloedbaan -> via glycolyse door
E Cellen verwerkbaar


AEROBE GLYCOLYSE ANAEROBE GLYCOLYSE
(onder O , Zonder tussenkomst mitoch ( .




verdere oxidatie pyruvaat
=> CO2 reductie

Dyruvaat = Lactant

ATP :
fachrylering
in gistcellen :
glycolyse >
- al .
ferm .
= ethanoe



AEROOB mitoch .




OLUCOSE 2 Pyrmaat >
6 (2 + 6 Hz0

2 Lacta
Dist .
meikz
ANAEROOB
.




SLUCOCE 2
pyraat ac .



gist. 2 ethand + 2 (2

, STAP STAP 2

X-D-glucose X-D-glucose-6-phosphate X-D-glucose-6-fogaat X-D-fructose-6-tostaat
(audose) Sketose)
nexokinase glucokinase glucose- fOStO-
Calle cellen) (levers 6-10Stadt- glucose ISOMERISATIE
=




isomerase isomerase
CHzOP
O
Y-tosporylgroep van ATP-O-atoom op Co glucose (irreversibel H
O POCH2
"CHcOH
S
5 H 6




Top
4 1 2
5
CHzOH HO
60 · HO3 2
OH H 4 3 OH
H5 H H5 H

4 1 t ATP 4 1 + ADP + HT H OH OH H
OH OH
HO OH
3 2 HO 3 2
OH
X-D-guscose-6-phosphase X-D-fructose-6-phosphale
H OH H OH

X-D-glucose X-D-glucose-6-phosphase


nexorinase =
seutelenzym
↳ alosterische inhibitie door glucose-o-fostaat

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