Pharmacology 566 Midterm:
Week 2 Test Exam Questions
Merged With Correct Verified
And Well Analyzed Answers
Graded A+
Adverse reactions/pt. teaching: Itraconazole - ANSWER-Alternative to
amphotericin B for systemic mycoses
Cardio suppression, hepatotoxicity
Can inhibit metabolizing enzymes, raising other drug levels (i.e.
warfarin, cyclosporine, digoxin, quinidine)
Anthelmintics lifespan considerations: Infants - ANSWER-Inadequate
studies; weigh risk vs benefit
Anthelmintics lifespan considerations: pregnancy - ANSWER-Safe:
praziquantel, moxidectin
Safe in 2nd/3rd trimester: mebendazole, albendazole, pyrantel
pamoate
Anthelmintics: Diagnostics - ANSWER-Confirm infection, HCG, CBC,
LFTs for some drugs
, Anthelmintics: Monitoring - ANSWER-Albendazole-LFT, CBC
Mebendazole-LFT, CBC, renal function
Praziquantel-LFTs
Ivermectin/moxidectin-eye exam if abnormal @ baseline
Anthelmintics/antiretrovirals: Adverse effects - ANSWER-Liver/renal
impairment, bone marrow suppression, teratogenesis, gasping
syndrome (pyrantel), GI effects, CNS effects, Abd pain, hypersensitivity
reactions, Mazzotti reaction, pancreatitis, PR/QT prolongation,
Anthelmintics/antiretrovirals: High-risk patients - ANSWER-
Liver/kidney disease, anemia, bleeding disorders, infections,
hypotension, pancreatitis, infants, heart disease
Antifungal lifespan considerations: children/adolescents - ANSWER-
Safe in decreased doses, side effects similar to adults
Antifungal lifespan considerations: Infants - ANSWER-Nystatin for oral
candidiasis, fluconazole for systemic
Antifungal lifespan considerations: older adults - ANSWER-Increased
risk for achlorhydria d/t antifungal absorption unpredictability;
warfarin, phenytoin and oral hypoglycemics are increased by azoles
Antifungal lifespan considerations: pregnancy/breastfeeding -
ANSWER-P: Consider risks and benefits
BF: data is lacking, most considered safe in decreased doses EXCEPT
ketoconazole d/t risk of hepatotoxicity
Antiviral lifespan considerations: Infants - ANSWER-Not safe:
foscarnet, famciclovir, cidofovir, foscavir, rilpivirine, indinavir,
Week 2 Test Exam Questions
Merged With Correct Verified
And Well Analyzed Answers
Graded A+
Adverse reactions/pt. teaching: Itraconazole - ANSWER-Alternative to
amphotericin B for systemic mycoses
Cardio suppression, hepatotoxicity
Can inhibit metabolizing enzymes, raising other drug levels (i.e.
warfarin, cyclosporine, digoxin, quinidine)
Anthelmintics lifespan considerations: Infants - ANSWER-Inadequate
studies; weigh risk vs benefit
Anthelmintics lifespan considerations: pregnancy - ANSWER-Safe:
praziquantel, moxidectin
Safe in 2nd/3rd trimester: mebendazole, albendazole, pyrantel
pamoate
Anthelmintics: Diagnostics - ANSWER-Confirm infection, HCG, CBC,
LFTs for some drugs
, Anthelmintics: Monitoring - ANSWER-Albendazole-LFT, CBC
Mebendazole-LFT, CBC, renal function
Praziquantel-LFTs
Ivermectin/moxidectin-eye exam if abnormal @ baseline
Anthelmintics/antiretrovirals: Adverse effects - ANSWER-Liver/renal
impairment, bone marrow suppression, teratogenesis, gasping
syndrome (pyrantel), GI effects, CNS effects, Abd pain, hypersensitivity
reactions, Mazzotti reaction, pancreatitis, PR/QT prolongation,
Anthelmintics/antiretrovirals: High-risk patients - ANSWER-
Liver/kidney disease, anemia, bleeding disorders, infections,
hypotension, pancreatitis, infants, heart disease
Antifungal lifespan considerations: children/adolescents - ANSWER-
Safe in decreased doses, side effects similar to adults
Antifungal lifespan considerations: Infants - ANSWER-Nystatin for oral
candidiasis, fluconazole for systemic
Antifungal lifespan considerations: older adults - ANSWER-Increased
risk for achlorhydria d/t antifungal absorption unpredictability;
warfarin, phenytoin and oral hypoglycemics are increased by azoles
Antifungal lifespan considerations: pregnancy/breastfeeding -
ANSWER-P: Consider risks and benefits
BF: data is lacking, most considered safe in decreased doses EXCEPT
ketoconazole d/t risk of hepatotoxicity
Antiviral lifespan considerations: Infants - ANSWER-Not safe:
foscarnet, famciclovir, cidofovir, foscavir, rilpivirine, indinavir,
