WALDEN 6630 PSYCHOPHARMACOLOGY MIDTERM
STUDY GUIDE EXAM QUESTIONS AND CORRECT
VERIFIED ANSWERS ALL GRADED A+
Signs of Lithium toxicity include: - CORRECT ANSWER ✔✔- Acute renal
failure, ataxia, confusion, dysarthria, coma, and death
Serotonin regulates - CORRECT ANSWER ✔✔- Mood, emotion, feeding,
and reproductive behavior
This class of antidepressants binds to presynaptic SERT and inhibits them
from reuptake of serotonin to increase levels in the synaptic cleft to bind
with postsysnaptic 5HT2 receptors - CORRECT ANSWER ✔✔- SSRIs
First line therapy for MDD due to milder side effect profiles - CORRECT
ANSWER ✔✔- SSRIs
Six Common SSRIs - CORRECT ANSWER ✔✔- citalopram, escitalopram,
fluoxetine, fluvoxamine, sertraline, paroxetine
Onset of therapeutic benefit from SSRIs - CORRECT ANSWER ✔✔- 4-6
weeks
In addition to MDD, SSRIs also treat - CORRECT ANSWER ✔✔- Chronic
Anxiety, PTSD, OCD, and eating disorders (bulimia)
,Five Common side effects of SSRIs include - CORRECT ANSWER ✔✔-
Anxiety, insomnia, GI distress, sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years old
- CORRECT ANSWER ✔✔- suicidal ideation
Life threatening adverse effect of SSRIs, especially when used in
combination with other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) -
CORRECT ANSWER ✔✔- Serotonin Syndrome
Excess accumulation of serotonin resulting in overstimulation of the
nervous system - CORRECT ANSWER ✔✔- Serotonin Syndrome
Seven symptoms of Serotonin Syndrome - CORRECT ANSWER ✔✔-
Flushing, hyperthermia, agitation, muscle rigidity, seizure, coma,
HYPERreflexia
The treatment for serotonin syndrome - CORRECT ANSWER ✔✔-
Cyproheptadine (5-HT2 receptor antagonist)
Cyproheptadine treats serotonin syndrome by - CORRECT ANSWER ✔✔-
blocking 5-HT2 receptors (serotonin antagonist)
When SSRIs or SNRIs are stopped abruptly, common symptoms of
withdrawal include - CORRECT ANSWER ✔✔- Irritability, headaches, and
insomnia
, Medicine specific side effect of citalopram - CORRECT ANSWER ✔✔-
Prolonged QT interval (normal=0.4.-0.44 seconds)
This SSRI is pregnancy category D due to associations with congenital
heart defects - CORRECT ANSWER ✔✔- Paroxetine
All SSRIs but paroxetine (D) are pregnancy category - CORRECT
ANSWER ✔✔- C
Three SSRIs that are inhibitors of Cytochrome P450 enzymes - CORRECT
ANSWER ✔✔- fluoxetine, fluvoxamine, and paroxetine
Five common SNRIs include - CORRECT ANSWER ✔✔- duloxetine,
venlafaxine, desvenlafaxine, milnacipran, levomilnacipran
This antidepressant class of medications works by binding to presynaptic
SERT and NET to inhibit them from reuptake of serotonin and
norepinephrine to increase their levels in the synaptic cleft - CORRECT
ANSWER ✔✔- SNRIs
In addition to MDD SNRIs treat - CORRECT ANSWER ✔✔- Anxiety and
neuropathic pain (peripheral neuropathy)
Medication specific indications of duloxetine: - CORRECT ANSWER ✔✔-
urinary incontinence and Fibromyalgia
Medication specific indications of venlafaxine: - CORRECT ANSWER ✔✔-
social anxiety, panic disorders, PTSD, OCD, postmenopausal hot flashes
STUDY GUIDE EXAM QUESTIONS AND CORRECT
VERIFIED ANSWERS ALL GRADED A+
Signs of Lithium toxicity include: - CORRECT ANSWER ✔✔- Acute renal
failure, ataxia, confusion, dysarthria, coma, and death
Serotonin regulates - CORRECT ANSWER ✔✔- Mood, emotion, feeding,
and reproductive behavior
This class of antidepressants binds to presynaptic SERT and inhibits them
from reuptake of serotonin to increase levels in the synaptic cleft to bind
with postsysnaptic 5HT2 receptors - CORRECT ANSWER ✔✔- SSRIs
First line therapy for MDD due to milder side effect profiles - CORRECT
ANSWER ✔✔- SSRIs
Six Common SSRIs - CORRECT ANSWER ✔✔- citalopram, escitalopram,
fluoxetine, fluvoxamine, sertraline, paroxetine
Onset of therapeutic benefit from SSRIs - CORRECT ANSWER ✔✔- 4-6
weeks
In addition to MDD, SSRIs also treat - CORRECT ANSWER ✔✔- Chronic
Anxiety, PTSD, OCD, and eating disorders (bulimia)
,Five Common side effects of SSRIs include - CORRECT ANSWER ✔✔-
Anxiety, insomnia, GI distress, sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years old
- CORRECT ANSWER ✔✔- suicidal ideation
Life threatening adverse effect of SSRIs, especially when used in
combination with other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) -
CORRECT ANSWER ✔✔- Serotonin Syndrome
Excess accumulation of serotonin resulting in overstimulation of the
nervous system - CORRECT ANSWER ✔✔- Serotonin Syndrome
Seven symptoms of Serotonin Syndrome - CORRECT ANSWER ✔✔-
Flushing, hyperthermia, agitation, muscle rigidity, seizure, coma,
HYPERreflexia
The treatment for serotonin syndrome - CORRECT ANSWER ✔✔-
Cyproheptadine (5-HT2 receptor antagonist)
Cyproheptadine treats serotonin syndrome by - CORRECT ANSWER ✔✔-
blocking 5-HT2 receptors (serotonin antagonist)
When SSRIs or SNRIs are stopped abruptly, common symptoms of
withdrawal include - CORRECT ANSWER ✔✔- Irritability, headaches, and
insomnia
, Medicine specific side effect of citalopram - CORRECT ANSWER ✔✔-
Prolonged QT interval (normal=0.4.-0.44 seconds)
This SSRI is pregnancy category D due to associations with congenital
heart defects - CORRECT ANSWER ✔✔- Paroxetine
All SSRIs but paroxetine (D) are pregnancy category - CORRECT
ANSWER ✔✔- C
Three SSRIs that are inhibitors of Cytochrome P450 enzymes - CORRECT
ANSWER ✔✔- fluoxetine, fluvoxamine, and paroxetine
Five common SNRIs include - CORRECT ANSWER ✔✔- duloxetine,
venlafaxine, desvenlafaxine, milnacipran, levomilnacipran
This antidepressant class of medications works by binding to presynaptic
SERT and NET to inhibit them from reuptake of serotonin and
norepinephrine to increase their levels in the synaptic cleft - CORRECT
ANSWER ✔✔- SNRIs
In addition to MDD SNRIs treat - CORRECT ANSWER ✔✔- Anxiety and
neuropathic pain (peripheral neuropathy)
Medication specific indications of duloxetine: - CORRECT ANSWER ✔✔-
urinary incontinence and Fibromyalgia
Medication specific indications of venlafaxine: - CORRECT ANSWER ✔✔-
social anxiety, panic disorders, PTSD, OCD, postmenopausal hot flashes
