CBRS EXAM 2026 EXAMINATION TEST
COMPLETE QUESTIONS AND 100%
CORRECT ANSWERS UPDATED VERIFIED
GRADED A+
⩥ _______ are GABA gated channels but ______ are GPCR receptors.
Answer: GABA-A
GABA-B
⩥ drugs for GABA-A receptors mimic the neurosteroids ____, ____, and
____. Answer: benzodiazepines, barbituates, and ethanol
⩥ increases the frequency of GABA-A opening. Answer:
benzodiazepines
⩥ increase duration of GABA-A opening. Answer: barbituates
⩥ increase the frequency and duration of opening but is less selective
and modulates other channels like NMDA or glycine and not just
GABA-A. Answer: ethanol
,⩥ endogenous allosteric modulators of GABA-A channels that modulate
GABA channel opening; these are depressants. Answer: neurosteroids
⩥ what are the 3 basic steps in GPCR rceptors. Answer: 1. ligand (NT)
binds to receptor
2. G-protein activated
3. effector molecule activated
⩥ basic structure of GPCR. Answer: 1. the transmitter binding site
2/ the intracellular domain
⩥ the intracellular domain of a GPCR determines ______. Answer: type
of G protein that is activated (5 major types)
⩥ basic G protein mode of operation (5 steps). Answer: 1. inactive -->
alpha, beta, gamma subunits float together near membrane (alpha has
GDP)
2. NT binds and alpha exchanges GDP for GTP
3. alpha splits from beta/gamma this influences the effector protein
4. alpha inactivates by slowly converting GTP to GDP
5. alpha and beta/gamma recombine; start cycle over
⩥ ratio of major GPCR types to G protein types. Answer: 800 to 5
, many more GPCR types (the same G protein can be activated by more
than one GPCR)
⩥ all known NT have a _______ receptor. Answer: metabotropic
not all have ionotropic
⩥ 3 G protein types to remember. Answer: Gs, Gi, and Gq
⩥ shortcut pathway. Answer: effector proteins = ion channels
⩥ second messenger cascade example. Answer: effector proteins =
enzymes that produce second messengers
⩥ shortcut pathways are.... Answer: fast (not faster than LG tho) and
local (membrane-delimited pathway)
⩥ G protein beta/gamma activate _______. Answer: K+ channels
activate inhibitory receptors (ACh-gated M2 and M4; GABA-gated
GPCR GABA-B)
COMPLETE QUESTIONS AND 100%
CORRECT ANSWERS UPDATED VERIFIED
GRADED A+
⩥ _______ are GABA gated channels but ______ are GPCR receptors.
Answer: GABA-A
GABA-B
⩥ drugs for GABA-A receptors mimic the neurosteroids ____, ____, and
____. Answer: benzodiazepines, barbituates, and ethanol
⩥ increases the frequency of GABA-A opening. Answer:
benzodiazepines
⩥ increase duration of GABA-A opening. Answer: barbituates
⩥ increase the frequency and duration of opening but is less selective
and modulates other channels like NMDA or glycine and not just
GABA-A. Answer: ethanol
,⩥ endogenous allosteric modulators of GABA-A channels that modulate
GABA channel opening; these are depressants. Answer: neurosteroids
⩥ what are the 3 basic steps in GPCR rceptors. Answer: 1. ligand (NT)
binds to receptor
2. G-protein activated
3. effector molecule activated
⩥ basic structure of GPCR. Answer: 1. the transmitter binding site
2/ the intracellular domain
⩥ the intracellular domain of a GPCR determines ______. Answer: type
of G protein that is activated (5 major types)
⩥ basic G protein mode of operation (5 steps). Answer: 1. inactive -->
alpha, beta, gamma subunits float together near membrane (alpha has
GDP)
2. NT binds and alpha exchanges GDP for GTP
3. alpha splits from beta/gamma this influences the effector protein
4. alpha inactivates by slowly converting GTP to GDP
5. alpha and beta/gamma recombine; start cycle over
⩥ ratio of major GPCR types to G protein types. Answer: 800 to 5
, many more GPCR types (the same G protein can be activated by more
than one GPCR)
⩥ all known NT have a _______ receptor. Answer: metabotropic
not all have ionotropic
⩥ 3 G protein types to remember. Answer: Gs, Gi, and Gq
⩥ shortcut pathway. Answer: effector proteins = ion channels
⩥ second messenger cascade example. Answer: effector proteins =
enzymes that produce second messengers
⩥ shortcut pathways are.... Answer: fast (not faster than LG tho) and
local (membrane-delimited pathway)
⩥ G protein beta/gamma activate _______. Answer: K+ channels
activate inhibitory receptors (ACh-gated M2 and M4; GABA-gated
GPCR GABA-B)
