Page 1 of 165
ARLINGTON NURS 5334 / ACTUAL NURS
5334 QUIZE 2 PRACTICE EXAM AND STUDY
GUIDE 2026/2027 COMPLETE ACCURATE
EXAM REAL QUESTIONS AND CORRECT
DETAILED ANSWERS WITH RATIONALES
(VERIFIED ANSWERS) LATEST UPDATED
VERSION |GUARANTEED PASS A+ |BRAND
NEW! | UNIVERSIT
1. A patient with liver failure is prescribed a drug with high
hepatic extraction. What change in bioavailability should
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the nurse anticipate?
A. Decreased bioavailability
B. Increased bioavailability
C. No change in bioavailability
D. Variable, depends on renal function
Correct Answer: B – Increased bioavailability
Rationale: High hepatic extraction drugs undergo extensive
first-pass metabolism. Liver failure reduces first-pass effect,
increasing bioavailability and risk of toxicity.
2. Which pharmacokinetic process is primarily affected by a
patient’s decreased serum albumin?
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Correct Answer: B – Distribution
Rationale: Albumin binds acidic drugs. Hypoalbuminemia
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increases free (active) drug fraction, altering distribution and
potentially causing toxicity.
3. A drug with a half-life of 12 hours is administered
intravenously. Approximately how many hours until steady
state is reached?
A. 24 hours
B. 36 hours
C. 48 hours
D. 60 hours
Correct Answer: D – 60 hours
Rationale: Steady state is reached after 4–5 half-lives. 5 × 12
= 60 hours.
4. A patient is on a drug that follows zero-order kinetics.
Which statement is correct?
A. A constant percentage of drug is eliminated per hour
B. A constant amount of drug is eliminated per hour
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C. Half-life remains constant regardless of dose
D. Doubling the dose doubles elimination rate
Correct Answer: B – A constant amount of drug is
eliminated per hour
Rationale: Zero-order kinetics (e.g., phenytoin, alcohol)
saturates metabolic enzymes; constant amount (not
percentage) cleared per unit time.
5. A nurse administers a cholinergic agonist. Which receptor
type is primarily stimulated to cause bradycardia?
A. Nicotinic N
B. Nicotinic M
C. Muscarinic M2
D. Muscarinic M3
Correct Answer: C – Muscarinic M2
Rationale: M2 receptors in the heart mediate bradycardia and
decreased contractility.
ARLINGTON NURS 5334 / ACTUAL NURS
5334 QUIZE 2 PRACTICE EXAM AND STUDY
GUIDE 2026/2027 COMPLETE ACCURATE
EXAM REAL QUESTIONS AND CORRECT
DETAILED ANSWERS WITH RATIONALES
(VERIFIED ANSWERS) LATEST UPDATED
VERSION |GUARANTEED PASS A+ |BRAND
NEW! | UNIVERSIT
1. A patient with liver failure is prescribed a drug with high
hepatic extraction. What change in bioavailability should
,Page 2 of 165
the nurse anticipate?
A. Decreased bioavailability
B. Increased bioavailability
C. No change in bioavailability
D. Variable, depends on renal function
Correct Answer: B – Increased bioavailability
Rationale: High hepatic extraction drugs undergo extensive
first-pass metabolism. Liver failure reduces first-pass effect,
increasing bioavailability and risk of toxicity.
2. Which pharmacokinetic process is primarily affected by a
patient’s decreased serum albumin?
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Correct Answer: B – Distribution
Rationale: Albumin binds acidic drugs. Hypoalbuminemia
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increases free (active) drug fraction, altering distribution and
potentially causing toxicity.
3. A drug with a half-life of 12 hours is administered
intravenously. Approximately how many hours until steady
state is reached?
A. 24 hours
B. 36 hours
C. 48 hours
D. 60 hours
Correct Answer: D – 60 hours
Rationale: Steady state is reached after 4–5 half-lives. 5 × 12
= 60 hours.
4. A patient is on a drug that follows zero-order kinetics.
Which statement is correct?
A. A constant percentage of drug is eliminated per hour
B. A constant amount of drug is eliminated per hour
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C. Half-life remains constant regardless of dose
D. Doubling the dose doubles elimination rate
Correct Answer: B – A constant amount of drug is
eliminated per hour
Rationale: Zero-order kinetics (e.g., phenytoin, alcohol)
saturates metabolic enzymes; constant amount (not
percentage) cleared per unit time.
5. A nurse administers a cholinergic agonist. Which receptor
type is primarily stimulated to cause bradycardia?
A. Nicotinic N
B. Nicotinic M
C. Muscarinic M2
D. Muscarinic M3
Correct Answer: C – Muscarinic M2
Rationale: M2 receptors in the heart mediate bradycardia and
decreased contractility.
