MISSOURI MPJE EXAM 2026 QUESTION BANK
CONTROLLED SUBSTANCES MODULE SOLVED
ITEMS AND RESPONSE KEY
◉ When may a RPh partial fill CII? Answer: Out of stock (must give
remainder in 72 hours) and LTCF or terminally ill patients.
◉ Who is responsible for the CS drugs in E-Kits? Answer: The LTCF.
◉ Who regulates CS stock (E-kits) in LTCF? Answer: BNDD. DEA
does not register or regulate LTCF.
◉ T/F Narcotic drugs can be used to ween patients off narcotics
Answer: False.
◉ Can methadone be prescribed for opioid dependence? Answer:
Mostly no. Only for infants (must document that patient is an infant)
and practitioner may administer methadone for 3 days as patient is
getting placed in narcotic treatment program.
◉ T/F: RPh may dispense CS to directly to a prescriber for office use.
Answer: False. Must obtain a patient-specific Rx.
,◉ T/F: MO prescribers may prescribe CS for themselves. Answer:
False.
◉ T/F: MO mid-level practitioners may not prescribe to family
members. Answer: True.
◉ How does BNDD define "insignificant loss"? Answer: Insignificant
loss is breaking a tablet or liquid sticking to the side of the bottle.
You know where the drug is. It was not LOST. Requires
documentation and attach to inventory.
◉ How must you report loss or theft to BNDD? Answer: Immediately
report via phone, fax, or email. Must submit loss report within 7
days.
◉ T/F An agent from a prescribers office calls to authorize an
emergency fill of hydromorphone for pain for a patient requiring
potent pain meds ASAP. She states the pain is so severe only
hydromorphone will do. She only authorizes a 3 day amount and will
have the Rx to you within the next few days. This is legal. Answer:
False. Emergency fills can only be verbally authorized by prescriber,
not an agent.
◉ How many refills are allowable on CIII-IV Rx? Answer: 5 refills
,◉ How many refills are allowable on CV Rx? Answer: As authorized
by physician.
◉ What is the quantity limit on CIII-V Rx? Answer: 90 day supply
◉ How long is a CIII-IV Rx valid? Answer: 6 months
◉ How long is a CV Rx valid? Answer: 1 year
◉ What does CMEA stand for? Answer: Combat Methamphetamine
Epidemic Act
◉ Which form is used for new pharmacy registration with DEA?
Answer: DEA Form 224
◉ Which form is used to renew pharmacy registration with DEA?
Answer: DEA Form 224a
◉ Which form can be used to renew pharmacy registration with
DEA for a chain pharmacy? Answer: DEA Form 224b
◉ What is required when a pharmacy chooses to terminate its
registration with the DEA? Answer: Return DEA registration
certificate and unused DEA 222 Forms.
, ◉ Which form is used by manufacturers to register with the DEA?
Answer: DEA Form 225
◉ What color is Copy 1, Copy 2, and Copy 3 of DEA 222 form?
Answer: Copy 1 is brown. Copy 2 is green. Copy 3 is blue.
◉ What happens to each copy of the DEA 222 Form? Answer:
Purchaser keeps Copy 3 for their records. Purchaser sends Copy 1
and 2 to the supplier to request drug order be filled. Supplier retains
Copy 1 for their files. Copy 2 is forwarded to the DEA by the supplier.
When purchaser receives drug order he/she should record, on Copy
3, the # of each item and date received.
◉ If a supplier cannot fill a particular drug on the Form 222
submitted by the purchaser, how long does the supplier have to ship
that item? Answer: 60 days.
◉ Which form is used when a registrant destroys CS inventory?
Answer: DEA Form 41
◉ When a reverse distributor is used for destruction, who is
responsible for submitting DEA Form 41 to the DEA? Pharmacy or
reverse distributor? Answer: Reverse distributor is responsible.
CONTROLLED SUBSTANCES MODULE SOLVED
ITEMS AND RESPONSE KEY
◉ When may a RPh partial fill CII? Answer: Out of stock (must give
remainder in 72 hours) and LTCF or terminally ill patients.
◉ Who is responsible for the CS drugs in E-Kits? Answer: The LTCF.
◉ Who regulates CS stock (E-kits) in LTCF? Answer: BNDD. DEA
does not register or regulate LTCF.
◉ T/F Narcotic drugs can be used to ween patients off narcotics
Answer: False.
◉ Can methadone be prescribed for opioid dependence? Answer:
Mostly no. Only for infants (must document that patient is an infant)
and practitioner may administer methadone for 3 days as patient is
getting placed in narcotic treatment program.
◉ T/F: RPh may dispense CS to directly to a prescriber for office use.
Answer: False. Must obtain a patient-specific Rx.
,◉ T/F: MO prescribers may prescribe CS for themselves. Answer:
False.
◉ T/F: MO mid-level practitioners may not prescribe to family
members. Answer: True.
◉ How does BNDD define "insignificant loss"? Answer: Insignificant
loss is breaking a tablet or liquid sticking to the side of the bottle.
You know where the drug is. It was not LOST. Requires
documentation and attach to inventory.
◉ How must you report loss or theft to BNDD? Answer: Immediately
report via phone, fax, or email. Must submit loss report within 7
days.
◉ T/F An agent from a prescribers office calls to authorize an
emergency fill of hydromorphone for pain for a patient requiring
potent pain meds ASAP. She states the pain is so severe only
hydromorphone will do. She only authorizes a 3 day amount and will
have the Rx to you within the next few days. This is legal. Answer:
False. Emergency fills can only be verbally authorized by prescriber,
not an agent.
◉ How many refills are allowable on CIII-IV Rx? Answer: 5 refills
,◉ How many refills are allowable on CV Rx? Answer: As authorized
by physician.
◉ What is the quantity limit on CIII-V Rx? Answer: 90 day supply
◉ How long is a CIII-IV Rx valid? Answer: 6 months
◉ How long is a CV Rx valid? Answer: 1 year
◉ What does CMEA stand for? Answer: Combat Methamphetamine
Epidemic Act
◉ Which form is used for new pharmacy registration with DEA?
Answer: DEA Form 224
◉ Which form is used to renew pharmacy registration with DEA?
Answer: DEA Form 224a
◉ Which form can be used to renew pharmacy registration with
DEA for a chain pharmacy? Answer: DEA Form 224b
◉ What is required when a pharmacy chooses to terminate its
registration with the DEA? Answer: Return DEA registration
certificate and unused DEA 222 Forms.
, ◉ Which form is used by manufacturers to register with the DEA?
Answer: DEA Form 225
◉ What color is Copy 1, Copy 2, and Copy 3 of DEA 222 form?
Answer: Copy 1 is brown. Copy 2 is green. Copy 3 is blue.
◉ What happens to each copy of the DEA 222 Form? Answer:
Purchaser keeps Copy 3 for their records. Purchaser sends Copy 1
and 2 to the supplier to request drug order be filled. Supplier retains
Copy 1 for their files. Copy 2 is forwarded to the DEA by the supplier.
When purchaser receives drug order he/she should record, on Copy
3, the # of each item and date received.
◉ If a supplier cannot fill a particular drug on the Form 222
submitted by the purchaser, how long does the supplier have to ship
that item? Answer: 60 days.
◉ Which form is used when a registrant destroys CS inventory?
Answer: DEA Form 41
◉ When a reverse distributor is used for destruction, who is
responsible for submitting DEA Form 41 to the DEA? Pharmacy or
reverse distributor? Answer: Reverse distributor is responsible.
