PTCB CSPT EXAM QUESTIONS AND
Verified ANSWERS 2026 Latest update
Patient harmed by compounded sterile preparations - correct answermicrobial
contamination, excessive bacterial endotoxins, variability in strength of ingredients,
chemical/physical contaminants, inappropriate quality of ingredients
non sterile compounding examples - correct answerproducts used orally, topically
on skin or to fill gaps when not commercially available
aesptic - correct correct answertate of being free from microbial contamination
sterile compounded items - correct answerinjections(iv, etc) ophthalmic drops,
aqueous bronchial or nasal inhalations, baths for live organs, tissue implants, irrigation
for wounds or cavities
Non hazardous hoods - correct answerLaminar airflow workbench (LAFW)
compounding containment isolator (CAI)
Hazardous hoods - correct answerbiological safety cabinet (BSC) compounding
aseptic containment isolator (CACI)
Primary Engineering Control (PEC) - correct answera device or room that provides
an ISO Class 5 environment for the exposure of critical sites when compounding CSPs.
Such devices include, but may not be limited to, laminar airflow workbenches (LAFWs),
biological safety cabinets (BSCs), compounding aseptic isolators (CAIs), and
compounding aseptic containment isolators (CACIs).
secondary engineering controls - correct answerthe ante area and buffer area
Buffer or Clean Room - correct answerISO 7
Ante Room ISO class - correct answerISO 8, unless provides access to negative
pressure room then ISO 7
vertical hood - correct answerhazardous compounding-air flows vertically
, Horizontal Hood - correct answerair flows horizontally across the work area from
back to front
Direct Compounding Area (DCA) - correct answer- a critical area within the hood
(ISO Class 5) where areas are exposed to filtered air; also known as "first air"
Negative Pressure room - correct answerHazardous materials
High-efficiency particulate air (HEPA) filters - correct answerremove microbes > 0.3
micrometers
Ante Room - correct answerwashing, garbing, product decontamination
Buffer area air change per hour (APCH) - correct answer30 exchanges per hour
ante room air change per hour (APCH) - correct answerISO 8-20 per hour ISO 7- 30
per hour
Cleaning of compounding area - correct answergermicidal detergent & water for
visible solids, 70% isopropyl alcohol
ISO Class 5 PEC cleaned - correct answerbeginning of each shift, before each
batch, every 30 minus when compounding, after spills, contamination
Cleaning of Counters and floors of specific sites - correct answerdaily
Cleaning Walls, ceilings, storage shelving: - correct answermonthly
Suface sampling frequency - correct answerevery 6 months or significant changes
in procedure
Temperature of CSP areas - correct answerroom temperature 20'C(68'F) or cooler
Airborne Particle Testing - correct answerevery 6 months or device relocated or
serviced
ISO class 5 Particle Limit for sterile compounding - correct answer3,520 particles
that are 0.5 micron or larger
ISO Class 7 Particle Limit for sterile compounding - correct answer352,000 particles
that are 0.5 micron or larger
Verified ANSWERS 2026 Latest update
Patient harmed by compounded sterile preparations - correct answermicrobial
contamination, excessive bacterial endotoxins, variability in strength of ingredients,
chemical/physical contaminants, inappropriate quality of ingredients
non sterile compounding examples - correct answerproducts used orally, topically
on skin or to fill gaps when not commercially available
aesptic - correct correct answertate of being free from microbial contamination
sterile compounded items - correct answerinjections(iv, etc) ophthalmic drops,
aqueous bronchial or nasal inhalations, baths for live organs, tissue implants, irrigation
for wounds or cavities
Non hazardous hoods - correct answerLaminar airflow workbench (LAFW)
compounding containment isolator (CAI)
Hazardous hoods - correct answerbiological safety cabinet (BSC) compounding
aseptic containment isolator (CACI)
Primary Engineering Control (PEC) - correct answera device or room that provides
an ISO Class 5 environment for the exposure of critical sites when compounding CSPs.
Such devices include, but may not be limited to, laminar airflow workbenches (LAFWs),
biological safety cabinets (BSCs), compounding aseptic isolators (CAIs), and
compounding aseptic containment isolators (CACIs).
secondary engineering controls - correct answerthe ante area and buffer area
Buffer or Clean Room - correct answerISO 7
Ante Room ISO class - correct answerISO 8, unless provides access to negative
pressure room then ISO 7
vertical hood - correct answerhazardous compounding-air flows vertically
, Horizontal Hood - correct answerair flows horizontally across the work area from
back to front
Direct Compounding Area (DCA) - correct answer- a critical area within the hood
(ISO Class 5) where areas are exposed to filtered air; also known as "first air"
Negative Pressure room - correct answerHazardous materials
High-efficiency particulate air (HEPA) filters - correct answerremove microbes > 0.3
micrometers
Ante Room - correct answerwashing, garbing, product decontamination
Buffer area air change per hour (APCH) - correct answer30 exchanges per hour
ante room air change per hour (APCH) - correct answerISO 8-20 per hour ISO 7- 30
per hour
Cleaning of compounding area - correct answergermicidal detergent & water for
visible solids, 70% isopropyl alcohol
ISO Class 5 PEC cleaned - correct answerbeginning of each shift, before each
batch, every 30 minus when compounding, after spills, contamination
Cleaning of Counters and floors of specific sites - correct answerdaily
Cleaning Walls, ceilings, storage shelving: - correct answermonthly
Suface sampling frequency - correct answerevery 6 months or significant changes
in procedure
Temperature of CSP areas - correct answerroom temperature 20'C(68'F) or cooler
Airborne Particle Testing - correct answerevery 6 months or device relocated or
serviced
ISO class 5 Particle Limit for sterile compounding - correct answer3,520 particles
that are 0.5 micron or larger
ISO Class 7 Particle Limit for sterile compounding - correct answer352,000 particles
that are 0.5 micron or larger
