Pathophysiology Biologic Basis for Disease 8th Edition Test Bank Updated Latest 2026–2027 Advanced Exam Preparation Resource for Nursing and Health Science Students Covering Core Disease Mechanisms and Clinical Applications.

TEST BANK
PATHOPHYSIOLOGY
The Biologic Basis For Disease In
Adults And Children
8TH EDITION BY KATHRYN L.
MCCANCE

,McCance: Pathophysiology: The Biologic Basis for Disease in Adults and Children (8th Edition) TEST
BANK


CONTENTS:
Chapter 01: Cellular Biology
Chapter 02: Altered Cellular and Tissue Biology: Environmental Agents
Chapter 03: The Cellular Environment: Fluids and Electrolytes, Acids and Bases
Chapter 04: Genes and Genetic Diseases
Chapter 05: Genes, Environment-Lifestyle, and Common Diseases
Chapter 06: Epigenetics and Disease
Chapter 07: Innate Immunity: Inflammation and Wound Healing
Chapter 08: Adaptive Immunity
Chapter 09: Alterations in Immunity and Inflammation
Chapter 10: Infection
Chapter 11: Stress and Disease
Chapter 12: Cancer Biology
Chapter 13: Cancer Epidemiology
Chapter 14: Cancer in Children
Chapter 15: Structure and Function of the Neurologic System
Chapter 16: Pain, Temperature Regulation, Sleep, and Sensory Function
Chapter 17: Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function
Chapter 18: Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction
Chapter 19: Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders
Chapter 20: Alterations of Neurologic Function in Children
Chapter 21: Mechanisms of Hormonal Regulation
Chapter 22: Alterations of Hormonal Regulation
Chapter 23: Obesity and Disorders of Nutrition
Chapter 24: Structure and Function of the Reproductive Systems
Chapter 25: Alterations of the Female Reproductive System
Chapter 26: Alterations of the Male Reproductive System
Chapter 27: Sexually Transmitted Infections
Chapter 28: Structure and Function of the Hematologic System
Chapter 29: Alterations of Erythrocytes, Platelets, and Hemostatic Function
Chapter 30: Alterations of Leukocyte and Lymphoid Function
Chapter 31: Alterations of Hematologic Function in Children
Chapter 32: Structure and Function of the Cardiovascular and Lymphatic Systems
Chapter 33: Alterations of Cardiovascular Function
Chapter 34: Alterations of Cardiovascular Function in Children
Chapter 35: Structure and Function of the Pulmonary System
Chapter 36: Alterations of Pulmonary Function
Chapter 37: Alterations of Pulmonary Function in Children
Chapter 38: Structure and Function of the Renal and Urologic Systems
Chapter 39: Alterations of Renal and Urinary Tract Function
Chapter 40: Alterations of Renal and Urinary Tract Function in Children
Chapter 41: Structure and Function of the Digestive System
Chapter 42: Alterations of Digestive Function
Chapter 43: Alterations of Digestive Function in Children
Chapter 44: Structure and Function of the Musculoskeletal System
Chapter 45: Alterations of Musculoskeletal Function
Chapter 46: Alterations of Musculoskeletal Function in Children
Chapter 47: Structure, Function, and Disorders of the Integument
Chapter 48: Alterations of the Integument in Children
Chapter 49: Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults
Chapter 50: Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children

, McCance: Pathophysiology: The Biologic Basis for Disease in Adults and Children (8th Edition) TEST BANK



Part 1: CENTRAL CONCEPTS OF PATHOPHYSIOLOGY: CELLS AND TISSUES
Unit I: THE CELL

CHAPTER 01: CELLULAR BIOLOGY

MULTIPLE CHOICE

1. Which statement best describes the cellular function of metabolic absorption? T T T T T T



a. Cells can produce proteins. T T T



b. Cells can secrete digestive enzymes.
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c. Cells can take in and use nutrients.
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d. Cells can synthesize fats. T T T




ANS: C T



In metabolic absorption, all cells take in and use nutrients and other substances from their
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surroundings. The remaining options are not inclusive in their descriptions of cellular metabolic
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absorption.

PTS: T T 1 DIF: Cognitive Level: Remembering T T




2. Where is most of a cell’s genetic information, including RNA and DNA, contained?
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a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome

ANS: C T



The nucleus contains the nucleolus, a small dense structure composed largely of RNA, most of
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the cellular DNA, and the DNA-binding proteins, such as the histones, which regulate its
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activity. The mitochondria are responsible for cellular respiration and energy production.
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Ribosomes’ chief function is to provide sites for cellular protein synthesis. Lysosomes function as
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the intracellular digestive system.
T T T




PTS: T T 1 DIF: Cognitive Level: Remembering T T




3. Which component of the cell produces hydrogen peroxide (H2O2) by using oxygen to remove
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hydrogen atoms from specific substrates in an oxidative reaction?
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a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome

ANS: B T

, McCance: Pathophysiology: The Biologic Basis for Disease in Adults and Children (8th Edition) TEST BANK



Peroxisomes are so named because they usually contain enzymes that use oxygen to remove
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hydrogen atoms from specific substrates in an oxidative reaction that produces H2O2, which is a
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powerful oxidant and potentially destructive if it accumulates or escapes from peroxisomes.
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Ribosomes are RNA-protein complexes (nucleoproteins) that are synthesized in the nucleolus
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and secreted into the cytoplasm through pores in the nuclear envelope called nuclear pore
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complexes. Lysosomes are saclike structures that originate from the Golgi complex and contain
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more than 40 digestive enzymes called hydrolases, which catalyze bonds in proteins, lipids,
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nucleic acids, and carbohydrates. An endosome is a vesical that has been pinched off from the
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cellular membrane. T




PTS: T T 1 DIF: Cognitive Level: Remembering T T




4. Which cell component is capable of cellular autodigestion when it is released during cell injury?
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a. Ribosome
b. Golgi complex T



c. Smooth endoplasmic reticulum T T



d. Lysosomes

ANS: D T



The lysosomal membrane acts as a protective shield between the powerful digestive enzymes
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within the lysosome and the cytoplasm, preventing their leakage into the cytoplasmic matrix.
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Disruption of the membrane by various treatments or cellular injury leads to a release of the
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lysosomal enzymes, which can then react with their specific substrates, causing cellular self-
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digestion. The chief function of a ribosome is to provide sites for cellular protein synthesis. The
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Golgi complex is a network of flattened, smooth vesicles and membranes often located near the
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cell nucleus. The smooth endoplasmic reticulum is involved in steroid hormone production and
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removing toxic substances from the cell.
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PTS: T T 1 DIF: Cognitive Level: Remembering T T




5. Which cAMP-mediated response is related to antidiuretic hormone?
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a. Increased heart rate and force of contraction T T T T T T



b. Secretion of cortisol T T



c. Increased retention of water T T T



d. Breakdown of fat T T




ANS: C T



Antidiuretic hormone leads to increased retention of water in the body. Epinephrine causes
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increases in heart rate and force of contraction. Increased cortisol secretion is due to ACTH.
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Breakdown of fat is due to glucagon. T T T T T T




PTS: T T 1 DIF: Cognitive Level: Remembering T T




6. During which phase of the cell cycle is DNA synthesized?
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a. G1
b. S
c. G2
d. M