RASMUSSEN PHARMACOLOGY EXAM 2 2026
EXAM PREPARATION PACK KEY MEDICATION
SAFETY PHARMACOKINETICS AND ADVERSE
EFFECTS WITH SAMPLE QUESTIONS
◉ AE of dextromethorphan Answer: Nausea, vomiting, constipation,
sedation, drowsiness, confusion, dizzy and nervousness
◉ This non-narcotic antitussive actually provides low local
anesthetic effects on the anesthetized stretch, receptors in the
respiratory passage and lungs Answer: Benzonatate
◉ When you think tessalon perles, think of what? Answer:
Anesthetic
◉ What is the first choice and most effective treatment prevention of
rhinitis? Answer: Intranasal glucocorticoids
◉ AE of intranasal glucocorticoids Answer: Drying of nasal mucosa,
Burning or itching sensation, Sore throat, Epistaxis, Headache
◉ What do you give intranasal glucocorticoids for? Answer:
Congestion, rhinorrhea, sneezing and nasal itching
,◉ This is a rare but serious AE that can occur from glucocorticoids
Answer: Adrenal suppression and slowing of linear pediatric growth
◉ What is adrenal suppression? Answer: -Disorder when the
adrenal glands don't produce enough hormones
◉ What is cimetidine? Answer: H2 receptor antagonist
◉ What is Cimetidine used for? Answer: Prevention and treatment
of PUD, GERD, esophagitis, GI bleeding, Zollnger-Ellison syndrome
◉ AE of cimetidine Answer: Anti-Androgenic Effects:
1) Gynecomastia
2) Galactorrhea
3) Male impotence
*b/c it will act as a NON-steroidal anti-androgen/prolactin
stimulants
...and will also BLOCK the androgen receptors
CNS effects:
-Crosses the BBB= confusion, dizziness, headaches (don't give to old
people who are already confused like for Alzheimer's patients)
, Long Term Use AE:
-Increased Gastric pH
-Thus you will get B12 deficiency (bc the acid in the stomach acid is
used to release it from animal product food)
...thus you will get myelosuppression
(ie if you use it LONG TERM)
CYP Inhibition:
-CYP450 Inhibitor: increased concentration of...
1) Warfarin= increased bleeding
2) Diazepam (ie normally used for sedation & respiratory
depression)
3) Phenytoin (ie anti-epileptic drug)
◉ Cimetidine MOA Answer: Inhibits the action of histamine at the
H2 -receptor site located primarily in gastric parietal cells, resulting
in inhibition of gastric acid secretion.
◉ Cause of peptic ulcers? Answer: -H. pylori and NSAIDs
-Ziollinger Ellison syndrome
-Smoking
EXAM PREPARATION PACK KEY MEDICATION
SAFETY PHARMACOKINETICS AND ADVERSE
EFFECTS WITH SAMPLE QUESTIONS
◉ AE of dextromethorphan Answer: Nausea, vomiting, constipation,
sedation, drowsiness, confusion, dizzy and nervousness
◉ This non-narcotic antitussive actually provides low local
anesthetic effects on the anesthetized stretch, receptors in the
respiratory passage and lungs Answer: Benzonatate
◉ When you think tessalon perles, think of what? Answer:
Anesthetic
◉ What is the first choice and most effective treatment prevention of
rhinitis? Answer: Intranasal glucocorticoids
◉ AE of intranasal glucocorticoids Answer: Drying of nasal mucosa,
Burning or itching sensation, Sore throat, Epistaxis, Headache
◉ What do you give intranasal glucocorticoids for? Answer:
Congestion, rhinorrhea, sneezing and nasal itching
,◉ This is a rare but serious AE that can occur from glucocorticoids
Answer: Adrenal suppression and slowing of linear pediatric growth
◉ What is adrenal suppression? Answer: -Disorder when the
adrenal glands don't produce enough hormones
◉ What is cimetidine? Answer: H2 receptor antagonist
◉ What is Cimetidine used for? Answer: Prevention and treatment
of PUD, GERD, esophagitis, GI bleeding, Zollnger-Ellison syndrome
◉ AE of cimetidine Answer: Anti-Androgenic Effects:
1) Gynecomastia
2) Galactorrhea
3) Male impotence
*b/c it will act as a NON-steroidal anti-androgen/prolactin
stimulants
...and will also BLOCK the androgen receptors
CNS effects:
-Crosses the BBB= confusion, dizziness, headaches (don't give to old
people who are already confused like for Alzheimer's patients)
, Long Term Use AE:
-Increased Gastric pH
-Thus you will get B12 deficiency (bc the acid in the stomach acid is
used to release it from animal product food)
...thus you will get myelosuppression
(ie if you use it LONG TERM)
CYP Inhibition:
-CYP450 Inhibitor: increased concentration of...
1) Warfarin= increased bleeding
2) Diazepam (ie normally used for sedation & respiratory
depression)
3) Phenytoin (ie anti-epileptic drug)
◉ Cimetidine MOA Answer: Inhibits the action of histamine at the
H2 -receptor site located primarily in gastric parietal cells, resulting
in inhibition of gastric acid secretion.
◉ Cause of peptic ulcers? Answer: -H. pylori and NSAIDs
-Ziollinger Ellison syndrome
-Smoking
