WGU D116 ADVANCED PHARMACOLOGY OA EXAM TEST BANK 500 QUESTIONS
WITH DETAILED VERIFIED GRADED A+ PASS GUARANTEED - A+ GRADED
COMPLETE SOLUTIONS
1.
A patient reports oral morphine is less effective than IV morphine. Why?
A. Faster excretion
B. First-pass metabolism
C. Protein binding
D. Delayed onset
Answer: B
Rationale: Oral morphine undergoes hepatic first-pass metabolism → ↓ bioavailability.
2.
A high therapeutic index indicates:
A. High toxicity
B. Narrow safety margin
C. Wide safety margin
D. Requires monitoring
Answer: C
,3.
Steady state occurs after:
A. 1 half-life
B. 2 half-lives
C. 4–5 half-lives
D. 10 half-lives
Answer: C
4.
Half-life determines:
A. Potency
B. Duration
C. Absorption
D. Distribution
Answer: B
5.
Bioavailability refers to:
A. Drug metabolism
B. Drug reaching circulation
C. Excretion
D. Protein binding
Answer: B
2 of 24
, 6.
A highly protein-bound drug:
A. Is inactive
B. Has less free drug
C. Is eliminated faster
D. Has higher absorption
Answer: B
7.
Drug displacement increases:
A. Bound drug
B. Free drug → toxicity
C. Absorption
D. Half-life
Answer: B
8.
IV drugs:
A. Have first-pass metabolism
B. Have 100% bioavailability
C. Are slower
D. Are less effective
Answer: B
9.
First-pass metabolism occurs in:
A. Kidney
B. Liver
C. Lungs
D. Brain
Answer: B
10.
Which route partially avoids first-pass?
A. Oral
B. IV
C. Rectal
WITH DETAILED VERIFIED GRADED A+ PASS GUARANTEED - A+ GRADED
COMPLETE SOLUTIONS
1.
A patient reports oral morphine is less effective than IV morphine. Why?
A. Faster excretion
B. First-pass metabolism
C. Protein binding
D. Delayed onset
Answer: B
Rationale: Oral morphine undergoes hepatic first-pass metabolism → ↓ bioavailability.
2.
A high therapeutic index indicates:
A. High toxicity
B. Narrow safety margin
C. Wide safety margin
D. Requires monitoring
Answer: C
,3.
Steady state occurs after:
A. 1 half-life
B. 2 half-lives
C. 4–5 half-lives
D. 10 half-lives
Answer: C
4.
Half-life determines:
A. Potency
B. Duration
C. Absorption
D. Distribution
Answer: B
5.
Bioavailability refers to:
A. Drug metabolism
B. Drug reaching circulation
C. Excretion
D. Protein binding
Answer: B
2 of 24
, 6.
A highly protein-bound drug:
A. Is inactive
B. Has less free drug
C. Is eliminated faster
D. Has higher absorption
Answer: B
7.
Drug displacement increases:
A. Bound drug
B. Free drug → toxicity
C. Absorption
D. Half-life
Answer: B
8.
IV drugs:
A. Have first-pass metabolism
B. Have 100% bioavailability
C. Are slower
D. Are less effective
Answer: B
9.
First-pass metabolism occurs in:
A. Kidney
B. Liver
C. Lungs
D. Brain
Answer: B
10.
Which route partially avoids first-pass?
A. Oral
B. IV
C. Rectal
