BMTCN COMPREHENSIVE EXAMINATION
TEST 2026 FULL QUESTIONS AND
CORRECT ANSWERS
◉Why can progenitor cells not renew? Answer: They always
commit to one specific cell differentiation pathways that lead to the
production of specific blood cells
◉What two pools do HSCs belong to? Answer: One that is dormant
and proliferates every few months while maintaining self-renewal
potential. The other is activated and proliferates every thirty days.
This pool does not have self-renewal abilities
◉HSCs surface protein function: Answer: Serve as "markers" that
identify the type and function of the cell. These also provide
molecular signaling patterns that allow cells to communicate with
one another. This is the basis for cell-to-cell interaction.
◉What is a commonly recognized marker for HSCs? Answer: CD34,
used to separate cells from other populations of leukocytes
, ◉What is cluster differentiation? Answer: System used to identify
the evolutionary stage of blood cells, dictates the next steps in cell
maturation, serves as a regulatory signaler, and associates cells with
certain immune functions and properties. TL;DR, detect cell lineage,
differentiation, and maturation.
◉What does positive/negative lineage mean? Answer: Indicates
whether or not a cell possesses a surface marker specific to any
mature blood cell
◉LT-HSCs Answer: Long-term HSCs: primarily reside in the BM
environment, capacity for self renewal
◉ST-HSCs Answer: Short-term HSCs: give rise to multipotent
progenitors, enter the blood pathway for the myeloid or lymphoid
cell lineage
◉Myeloid progenitors give rise to...? Answer: Granulocyte-
monocyte progenitor and megakaryocyte-erythrocyte progenitor
◉Granulocyte-monocyte progenitor produce: Answer: Lineages,
which further generates neutrophils, basophils, eosinophils,
monocyte-macrophage lineages, and the dendritic cell lineages
TEST 2026 FULL QUESTIONS AND
CORRECT ANSWERS
◉Why can progenitor cells not renew? Answer: They always
commit to one specific cell differentiation pathways that lead to the
production of specific blood cells
◉What two pools do HSCs belong to? Answer: One that is dormant
and proliferates every few months while maintaining self-renewal
potential. The other is activated and proliferates every thirty days.
This pool does not have self-renewal abilities
◉HSCs surface protein function: Answer: Serve as "markers" that
identify the type and function of the cell. These also provide
molecular signaling patterns that allow cells to communicate with
one another. This is the basis for cell-to-cell interaction.
◉What is a commonly recognized marker for HSCs? Answer: CD34,
used to separate cells from other populations of leukocytes
, ◉What is cluster differentiation? Answer: System used to identify
the evolutionary stage of blood cells, dictates the next steps in cell
maturation, serves as a regulatory signaler, and associates cells with
certain immune functions and properties. TL;DR, detect cell lineage,
differentiation, and maturation.
◉What does positive/negative lineage mean? Answer: Indicates
whether or not a cell possesses a surface marker specific to any
mature blood cell
◉LT-HSCs Answer: Long-term HSCs: primarily reside in the BM
environment, capacity for self renewal
◉ST-HSCs Answer: Short-term HSCs: give rise to multipotent
progenitors, enter the blood pathway for the myeloid or lymphoid
cell lineage
◉Myeloid progenitors give rise to...? Answer: Granulocyte-
monocyte progenitor and megakaryocyte-erythrocyte progenitor
◉Granulocyte-monocyte progenitor produce: Answer: Lineages,
which further generates neutrophils, basophils, eosinophils,
monocyte-macrophage lineages, and the dendritic cell lineages
