BMTCN FINAL STUDY GUIDE 2026
COMPLETE SOLVED QUESTIONS 100%
CORRECT
◉Hematopoiesis occurs in which area?. Answer: bone marrow
which
◉which is true about innate immunity?. Answer: it's a natural
process that uses phagocytes that release inflammatory mediators in
response to infection or illness
◉aquired immunity. Answer: the response of either B cells or T cells
to antigens
◉human leukocyte antigen. Answer: -proteins that reside on the
surface of cells
-self v. nonself
◉which is not an indication for an allo transplant?
Breast cancer, AML, CML, MDS.. Answer: breast cancer
,◉graft v. tumor effect is promoted by which of the following?
1. withdrawal of immunosuppressants
2. a DLI
3. 1 and 2
4. more immunosuppressants. Answer: withdrawal of
immunosuppressants and DLI
◉autologous transplant. Answer: -removing stem cells from the
patient with the intent to reinfuse at a later date
-have to be disease free
-cells are cryopreserved
◉advantages of an auto transplant. Answer: -cells are available
-less side effects
-early engraftment
-low risk of GVH
◉matched related donor. Answer: most often a sibling
◉haploidentical. Answer: half-matched related
◉advantages of an allogeneic transplant. Answer: -disease free cells
,-potential for graft v. tumor
◉disadvantages of an allo transplant. Answer: -more side effects
-immunosuppresion therapy
-GVHD
◉advantages of peripheral blood stem cells (PBSC). Answer: -
engraftment faster
-outpatient setting
-no anesthesia necessary for donor
◉disadvantages of PBSC. Answer: -donor may need a central line
-collection could take days to get enough cells
-Apheresis has side effects like electrolyte imbalances and
thrombocytopenia
-chronic GVHD more likely
◉Advantages of bone marrow stem cells. Answer: -quicker harvest
of cells
-decreased GVHD
◉disadvantages of bone marrow stem cell collection. Answer: -
general anesthesia
, -longer time to engraft
◉Umbilical cord blood. Answer: -used when no match is found
◉advantages of UCB. Answer: -lower risk of GVHD
-decreased risk of viral disease transmission
◉disadvantages of UCB. Answer: -increased risk of passage of
genetic abnormalities
-less cells (may need multiple units)
-slower engraftment
-decreased GVT
-increased graft failure
-can't get more cells if needed
◉decreased risk of GVHD
1. UCB
2. PBSC
3. Bone marrow. Answer: UCB and Bone marrow
◉which cells may perceive the patient's cells as foreign?. Answer: T
lymphocytes
COMPLETE SOLVED QUESTIONS 100%
CORRECT
◉Hematopoiesis occurs in which area?. Answer: bone marrow
which
◉which is true about innate immunity?. Answer: it's a natural
process that uses phagocytes that release inflammatory mediators in
response to infection or illness
◉aquired immunity. Answer: the response of either B cells or T cells
to antigens
◉human leukocyte antigen. Answer: -proteins that reside on the
surface of cells
-self v. nonself
◉which is not an indication for an allo transplant?
Breast cancer, AML, CML, MDS.. Answer: breast cancer
,◉graft v. tumor effect is promoted by which of the following?
1. withdrawal of immunosuppressants
2. a DLI
3. 1 and 2
4. more immunosuppressants. Answer: withdrawal of
immunosuppressants and DLI
◉autologous transplant. Answer: -removing stem cells from the
patient with the intent to reinfuse at a later date
-have to be disease free
-cells are cryopreserved
◉advantages of an auto transplant. Answer: -cells are available
-less side effects
-early engraftment
-low risk of GVH
◉matched related donor. Answer: most often a sibling
◉haploidentical. Answer: half-matched related
◉advantages of an allogeneic transplant. Answer: -disease free cells
,-potential for graft v. tumor
◉disadvantages of an allo transplant. Answer: -more side effects
-immunosuppresion therapy
-GVHD
◉advantages of peripheral blood stem cells (PBSC). Answer: -
engraftment faster
-outpatient setting
-no anesthesia necessary for donor
◉disadvantages of PBSC. Answer: -donor may need a central line
-collection could take days to get enough cells
-Apheresis has side effects like electrolyte imbalances and
thrombocytopenia
-chronic GVHD more likely
◉Advantages of bone marrow stem cells. Answer: -quicker harvest
of cells
-decreased GVHD
◉disadvantages of bone marrow stem cell collection. Answer: -
general anesthesia
, -longer time to engraft
◉Umbilical cord blood. Answer: -used when no match is found
◉advantages of UCB. Answer: -lower risk of GVHD
-decreased risk of viral disease transmission
◉disadvantages of UCB. Answer: -increased risk of passage of
genetic abnormalities
-less cells (may need multiple units)
-slower engraftment
-decreased GVT
-increased graft failure
-can't get more cells if needed
◉decreased risk of GVHD
1. UCB
2. PBSC
3. Bone marrow. Answer: UCB and Bone marrow
◉which cells may perceive the patient's cells as foreign?. Answer: T
lymphocytes
