CPHON Brain Dump Questions and Correct Answers

CPHON Brain Dump Questions and Correct Answers Which phase of the cell cycle is hardest to kill cancer cells in? - Correct Answer G0 - resting phase What diagnosis is retinoic acid/ATRA used for? How does it work? Is it curative as a single agent? - Correct Answer Used for APML, forces promyelotic blasts to mature into healthy WBCs, not curative as a single agent but has increased remission, reduces relapse What type of drug is ritux? What diagnoses is it used for? What types of cells does it mostly target? - Correct Answer MAB, treats relapsed/refractory B-cell lymphomas, mostly targets CD20 cells What is the function of CD20? - Correct Answer Aids in cell development and differentiation, controls cell division and maturation Side effects of cisplat? Meds used to protect against ototoxicity? - Correct Answer Electrolyte imbalances (magnesium!), amifostine & thiosulfate used to prevent ototoxicity Risk factor for asparaginase? Symptoms associated? - Correct Answer Pancreatitis - abd pain, fever, tachycardia, hypotension, N/V, increased pancreatic enzymes, hypoglycemia, hypoactive bowel sounds Effects of VCR - Correct Answer Related to nerve damage - loss of DTRs, jaw pain, constipation, PERIPHERAL NEUROPATHY, droopy eyelids, vocal cord paralysis Chemos with lifetime dosing & why - Correct Answer Anthracyclines (doxo, dauno) due to cardiomyopathy, bleo due to PF Adverse effects of alkylating agents - Correct Answer N/V, changes in hormones, infertility, secondary malignancies Which phase of the cell cycle is hardest to kill cancer cells in? - Correct Answer G0 - resting phase What diagnosis is retinoic acid/ATRA used for? How does it work? Is it curative as a single agent? - Correct Answer Used for APML, forces promyelotic blasts to mature into healthy WBCs, not curative as a single agent but has increased remission, reduces relapse What type of drug is ritux? What diagnoses is it used for? What types of cells does it mostly target? - Correct Answer MAB, treats relapsed/refractory B-cell lymphomas, mostly targets CD20 cells What is the function of CD20? - Correct Answer Aids in cell development and differentiation, controls cell division and maturation Side effects of cisplat? Meds used to protect against ototoxicity? - Correct Answer Electrolyte imbalances (magnesium!), amifostine & thiosulfate used to prevent ototoxicity Risk factor for asparaginase? Symptoms associated? - Correct Answer Pancreatitis - abd pain, fever, tachycardia, hypotension, N/V, increased pancreatic enzymes, hypoglycemia, hypoactive bowel sounds Effects of VCR - Correct Answer Related to nerve damage - loss of DTRs, jaw pain, constipation, PERIPHERAL NEUROPATHY, droopy eyelids, vocal cord paralysis Chemos with lifetime dosing & why - Correct Answer Anthracyclines (doxo, dauno) due to cardiomyopathy, bleo due to PF Adverse effects of alkylating agents - Correct Answer N/V, changes in hormones, infertility, secondary malignancies