PTCE UPDATED 2026 EXAM SCRIPT QUESTIONS AND
ANSWERS GRADED A+
✔✔Comprehensive Drug Abuse Prevention and Control Act of 1970 - ✔✔established
schedules of controlled substances and moved enforcement to the Justice Department
(C-1 to C-5)
Established the DEA
✔✔DEA - ✔✔Enforces the controlled substance act under the DOJ. Makes sure all
controlled substances are manufactured, distributed, and stored properly.
✔✔Control 1 (C-1) drugs - ✔✔High abuse. Considered not medical use or street drugs.
(Marijuana, ecstasy, heroin, LSD)
✔✔Control 2 (C-II) drugs - ✔✔Consists of narcotics, pain killers, ADHD drugs. Highly
addicting (Percocet, Endocet, Norco, Fentanyl, Morphine)
✔✔Control 3 (C-III) drugs - ✔✔Mild pain killers, anabolic steroids and caffeine pills, can
be moderately abused (Tylenol 2, 3, 4; Vicodin; Depo-Testosterone; Buprenorphine;
Ketamine)
✔✔Control 4 (C-IV) drugs - ✔✔Anti-anxiety, anti-depressants, anti-psychotics, sleep
aids, appetite suppressants, Tramadol/Ultram. Has moderate abuse (alpralozam/Xanax,
Carisoprodol/soma, clonazepam/klonopin, lorazepam/Ativan, temazepam/restoril)
✔✔Control 5 (C-V) Drugs - ✔✔Low Codeine amounts in cough suppressants.
Considered the least abusive (phenergan w/Codeine, guaifenesin w/codeine)
✔✔Biennial Inventory - ✔✔exact count for schedule II and an estimated count for III-V
drugs must be performed every 2 years
✔✔C-II Supply - ✔✔Only for 30 days. No partial filling or given for 90 day supply
✔✔Does C-II must have a prescription hard copy? - ✔✔Yes, and there are exceptions:
for patients in community care or in long term IV care
✔✔Expiration date for C-II? - ✔✔No expiration date but just be filled in 1 month or in a
10 day period
✔✔Can doctor make a phone prescription for C-II? - ✔✔Only for extreme emergencies.
A hard copy must be sent to the pharmacy in 7 days or pharmacy can report the doctor
to DEA
, ✔✔DEA Form 222 - ✔✔must be used whenever Sch II drugs are bought, sold or
transferred between pharmacies or qualified distributors, can only order 10 medications
at a time
✔✔Form 222 triplicate forms? - ✔✔1) Seller
2) DEA
3) Pharmacy
✔✔How long must form 222 be kept in file? - ✔✔For 2 years
✔✔Can you make mistakes on form 222? - ✔✔No, must be mistake free. If a mistake is
made, it is kept on file
✔✔Can you loan Form 222 to other pharmacies? - ✔✔No, each form is different for
each pharmacy. Can loan medication to other pharmacies when ordering.
✔✔DEA Form 41 - ✔✔to destroy controlled substances
✔✔DEA Form 106 - ✔✔report of theft or loss of controlled substances
✔✔DEA form 224 - ✔✔New registration for Retail / Hospital / Clinic / Practitioner / Mid
level practitioner / teaching institution
✔✔When do you need to renew DEA Form 224? - ✔✔Every 3 years, and when
ownership of pharmacy changes
✔✔Perpetual Inventory Method - ✔✔keeps track of inventory levels on a daily basis
✔✔POS system - ✔✔A system in which the item is deducted from inventory as it is sold
or dispensed.
✔✔Initial Inventory - ✔✔is a complete and accurate inventory of all controlled
substances before the opening of the first day of business for a pharmacy or when
pharmacist in charge (PIC) is changed. You must also count all control 2 drugs
✔✔OSHA (Occupational Safety and Health Administration) - ✔✔The main federal
agency charged with regulating safety and health in the workplace. Offers workers
compensation and in charge of safety data sheets (SDS), which addresses how to clean
up medications.
✔✔The Joint Commission (TJC) - ✔✔An organization that accredits health care
organizations and programs
ANSWERS GRADED A+
✔✔Comprehensive Drug Abuse Prevention and Control Act of 1970 - ✔✔established
schedules of controlled substances and moved enforcement to the Justice Department
(C-1 to C-5)
Established the DEA
✔✔DEA - ✔✔Enforces the controlled substance act under the DOJ. Makes sure all
controlled substances are manufactured, distributed, and stored properly.
✔✔Control 1 (C-1) drugs - ✔✔High abuse. Considered not medical use or street drugs.
(Marijuana, ecstasy, heroin, LSD)
✔✔Control 2 (C-II) drugs - ✔✔Consists of narcotics, pain killers, ADHD drugs. Highly
addicting (Percocet, Endocet, Norco, Fentanyl, Morphine)
✔✔Control 3 (C-III) drugs - ✔✔Mild pain killers, anabolic steroids and caffeine pills, can
be moderately abused (Tylenol 2, 3, 4; Vicodin; Depo-Testosterone; Buprenorphine;
Ketamine)
✔✔Control 4 (C-IV) drugs - ✔✔Anti-anxiety, anti-depressants, anti-psychotics, sleep
aids, appetite suppressants, Tramadol/Ultram. Has moderate abuse (alpralozam/Xanax,
Carisoprodol/soma, clonazepam/klonopin, lorazepam/Ativan, temazepam/restoril)
✔✔Control 5 (C-V) Drugs - ✔✔Low Codeine amounts in cough suppressants.
Considered the least abusive (phenergan w/Codeine, guaifenesin w/codeine)
✔✔Biennial Inventory - ✔✔exact count for schedule II and an estimated count for III-V
drugs must be performed every 2 years
✔✔C-II Supply - ✔✔Only for 30 days. No partial filling or given for 90 day supply
✔✔Does C-II must have a prescription hard copy? - ✔✔Yes, and there are exceptions:
for patients in community care or in long term IV care
✔✔Expiration date for C-II? - ✔✔No expiration date but just be filled in 1 month or in a
10 day period
✔✔Can doctor make a phone prescription for C-II? - ✔✔Only for extreme emergencies.
A hard copy must be sent to the pharmacy in 7 days or pharmacy can report the doctor
to DEA
, ✔✔DEA Form 222 - ✔✔must be used whenever Sch II drugs are bought, sold or
transferred between pharmacies or qualified distributors, can only order 10 medications
at a time
✔✔Form 222 triplicate forms? - ✔✔1) Seller
2) DEA
3) Pharmacy
✔✔How long must form 222 be kept in file? - ✔✔For 2 years
✔✔Can you make mistakes on form 222? - ✔✔No, must be mistake free. If a mistake is
made, it is kept on file
✔✔Can you loan Form 222 to other pharmacies? - ✔✔No, each form is different for
each pharmacy. Can loan medication to other pharmacies when ordering.
✔✔DEA Form 41 - ✔✔to destroy controlled substances
✔✔DEA Form 106 - ✔✔report of theft or loss of controlled substances
✔✔DEA form 224 - ✔✔New registration for Retail / Hospital / Clinic / Practitioner / Mid
level practitioner / teaching institution
✔✔When do you need to renew DEA Form 224? - ✔✔Every 3 years, and when
ownership of pharmacy changes
✔✔Perpetual Inventory Method - ✔✔keeps track of inventory levels on a daily basis
✔✔POS system - ✔✔A system in which the item is deducted from inventory as it is sold
or dispensed.
✔✔Initial Inventory - ✔✔is a complete and accurate inventory of all controlled
substances before the opening of the first day of business for a pharmacy or when
pharmacist in charge (PIC) is changed. You must also count all control 2 drugs
✔✔OSHA (Occupational Safety and Health Administration) - ✔✔The main federal
agency charged with regulating safety and health in the workplace. Offers workers
compensation and in charge of safety data sheets (SDS), which addresses how to clean
up medications.
✔✔The Joint Commission (TJC) - ✔✔An organization that accredits health care
organizations and programs
