N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale
1. A 42 y / o woman is diagnosed with bacteremia in the ED . The NP empirically starts
antibiotics and want the first dose of Vancomycin to be given prior to admission to the floor . The
hospital has a vancomycin nomogram for 15 mg / kg initial dosing ( rounded to the nearest 250
mg ) , followed by pharmacy dosing / pharmacokinetic service . If the patient weighs 154 pounds
, what dose of vancomycin would the patient receive in the ED ? Please give your answer as a
whole number without units . - ANS-1000
3. In regard to pharmacodynamics , " affinity " can be defined as : CHOOSE ONE ANSWER
a . The measure of how tightly a drug binds to plasma proteins
b . The amount of time that a measurable drug effect persists
c . The degree of attraction between a drug and its receptor
d . The measure of a drug's bioavailability - ANS-c . The degree of attraction between a drug
and its receptor
4. Antagonist drugs prevent the actions of the body's endogenous biomediators on their
receptors by which mechanism ? CHOOSE ONE ANSWER
a . Preventing agonist drugs from binding to antagonist drug
b . Binding to the receptor and activating it
c . Preventing occupancy of the receptor
d . Mimicking the actions of the body's endogenous biomediators - ANS-c . Preventing
occupancy of the receptor
53. Which of the following medications can be used for the treatment of depression , insomnia ,
and migraines ?
a . SSRIs
b . MAOIS
c . TCAs
d . SNRIS - ANS-c . TCAs
8. Which of the following is an example of a graded drug response ? CHOOSE ONE ANSWER
a . Blood pressure
b . Death
c . Rash
d . Sleep - ANS-a . Blood pressure
A child who presents with a diagnosis of chlamydial pneumonia should be prescribed which of
the following antimicrobials
a . High dose amoxicillin ( Amoxil)
b . Amoxicillin + clavulanate (augmentin )
C. Ceftriaxone ( rocephin )
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
,N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
d . Macrolide - ANS-d . Macrolide
A combination of hydralazine and isorbide dinitrate has been shown to be beneficial in heart
failure patients who are
a. African American
b . Unable to tolerate an ACE inhibitor
C. > 65 years old
d . NYHA class II - ANS-a. African American
A common adverse drug reaction from ACE inhibitors prescribed in the setting of heart failure is
a . Reflex tachycardia
b Exacerbation of lower extremity edema
c . Hyperkalemia
d . Elevation of serum glucose in diabetics . - ANS-c . Hyperkalemia
A disadvantage of the antihistamine diphenhydramine ( Benadryl ) is
a . May cause bradycardia
b . Only available by the oral route
c . May cause urinary retention in men with prostate problems
d . Commonly causes diarrhea - ANS-c . May cause urinary retention in men with prostate
problems
A disadvantage to the use of nicotinic acid ( niacin ) for hyperlipidemia is
a . It will decrease the absorption of other oral drugs given simultaneously
b . It is associated with constipation
c . It commonly produces flushing in the face and neck area
d . It may cause a life - threatening myopathy - ANS-c . It commonly produces flushing in the
face and neck area
A drug's therapeutic index can be defined as
a . The drug dosage that produces 100 % of the therapeutic effect
b . The ratio of the average lethal dose of the drug compared to the average effective
therapeutic dose of the drug
c . A measurement of a drugs safety and toxicity
d . The time course of a drugs action - ANS-b . The ratio of the average lethal dose of the drug
compared to the average effective therapeutic dose of the drug
c . A measurement of a drugs safety and toxicity
A middle - aged executive who experienced insomnia with 2 different SSRIs . Which alternative
therapy could relieve insomnia and depression ?
a . MAOI
b . SNRI
c . TCA
d . Benzodiazepine - ANS-c . TCA
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
,N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
A new drug seeking FDA approval has been studied in pregnant rats , rabbits , and mice and
causes birth defects in these fetal animals . There are , however , no studies of this drug in
pregnant women . To which pregnancy risk category does this drug belong ?
a.A
b.B
c.C
d . D - ANS-c. C
A patient presenting to the ER in status epilepticus without IV access can be treated with
a . Fosphenytoin ( cerebyx )
b . Carbamazepine ( tegretol )
c . Lamotrigine ( Lamictal )
d . Phenytoin ( Dilantin ) - ANS-LOOK UP
A patient who took an osmotic laxative on a daily basis could develop this as a consequence
a . An impaction
b . Dehydration
C. Hyperglycemia
d . Hyperkalemia - ANS-b . Dehydration
A patient with phenytoin may exhibit drug toxicity when concurrently taking
a . Cimetidine
b . Famotidine
c . Acetaminophen
d . Aspirin - ANS-a . Cimetidine
A. drug half - life can be defined as
a . The time it takes , after a drug is administered , to reach an effective serum ( or tissue )
concentration that is capable of producing a minimal clinical response
b . The time it takes , after a drug is administered , to reach an effective serum ( or tissue )
concentration capable of producing a maximal clinical response
C. The total time a drug is present in the serum ( or tissue ) for it to produce any clinical effects (
minimal or max )
d . The time it takes , after a drug is administered , to reach an effective serum concentration
equal to one half of what it was at its peak concentration - ANS-d . The time it takes , after a
drug is administered , to reach an effective serum concentration equal to one half of what it was
at its peak concentration
According to JNC - 8 guidelines , which of the following is the blood pressure goal for patients
with diabetes ? CHOOSE ONE ANSWER
a . < 150/90
b . < 140/90
c . < 140/80
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
, N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
d . < 130/85 - ANS-b . < 140/90
According to the FDA , which drug for respiratory illness should not be given to children younger
than 2 years of age
a . Prednisone
b . Albuterol ( Ventolin )
c . N - acetylcysteine ( mucomyst )
d . Dextromethorphan ( delsym ) - ANS-d . Dextromethorphan ( delsym ) *
Administration of an antagonist drug results in
a . No direct pharmacologic action from the drug itself
b . An immediate " wearing out " of the receptors that are blocked by the drug
c. A binding process that causes a permanent alteration in the shape of the receptors
d. Enhanced interaction of the natural endogenous biomediator with the receptor . - ANS-a . No
direct pharmacologic action from the drug itself
Advair diskus contains a combination of
a . Salmeterol and fluticasone
b . Sameterol and acetylcysteine
C. Epinephrine and fluticasone
d . Cromolyn and fluticasone - ANS-a . Salmeterol and fluticasone
Advantages of using a nitrate drug in treatment of angina include
a . Therapy can be individualized because of multiple formulations and mechanism of actions
b . All formulations have a quick onset of action
C. Therapy can be withdrawn quickly without adverse effects
d . Therapy increases myocardial oxygen demand causing a decrease in the heart's workload -
ANS-a . Therapy can be individualized because of multiple formulations and mechanism of
actions
Agonist drugs mimic the actions of the body's exogenous biomediators on their receptors .
Which of the following is an agonist drug ?
a . Milrinone ( Primacor )
b . Atropine
c . Epinephrine
d . Theophylline - ANS-c . Epinephrine
Agonist drugs mimic the actions of the body's exogenous biomediators on their receptors .
Which of the following is an agonist drug ?
a . Milrinone ( Primacor )
b . Atropine
c . Epinephrine
d . Theophylline - ANS-c . Epinephrine
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale
1. A 42 y / o woman is diagnosed with bacteremia in the ED . The NP empirically starts
antibiotics and want the first dose of Vancomycin to be given prior to admission to the floor . The
hospital has a vancomycin nomogram for 15 mg / kg initial dosing ( rounded to the nearest 250
mg ) , followed by pharmacy dosing / pharmacokinetic service . If the patient weighs 154 pounds
, what dose of vancomycin would the patient receive in the ED ? Please give your answer as a
whole number without units . - ANS-1000
3. In regard to pharmacodynamics , " affinity " can be defined as : CHOOSE ONE ANSWER
a . The measure of how tightly a drug binds to plasma proteins
b . The amount of time that a measurable drug effect persists
c . The degree of attraction between a drug and its receptor
d . The measure of a drug's bioavailability - ANS-c . The degree of attraction between a drug
and its receptor
4. Antagonist drugs prevent the actions of the body's endogenous biomediators on their
receptors by which mechanism ? CHOOSE ONE ANSWER
a . Preventing agonist drugs from binding to antagonist drug
b . Binding to the receptor and activating it
c . Preventing occupancy of the receptor
d . Mimicking the actions of the body's endogenous biomediators - ANS-c . Preventing
occupancy of the receptor
53. Which of the following medications can be used for the treatment of depression , insomnia ,
and migraines ?
a . SSRIs
b . MAOIS
c . TCAs
d . SNRIS - ANS-c . TCAs
8. Which of the following is an example of a graded drug response ? CHOOSE ONE ANSWER
a . Blood pressure
b . Death
c . Rash
d . Sleep - ANS-a . Blood pressure
A child who presents with a diagnosis of chlamydial pneumonia should be prescribed which of
the following antimicrobials
a . High dose amoxicillin ( Amoxil)
b . Amoxicillin + clavulanate (augmentin )
C. Ceftriaxone ( rocephin )
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
,N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
d . Macrolide - ANS-d . Macrolide
A combination of hydralazine and isorbide dinitrate has been shown to be beneficial in heart
failure patients who are
a. African American
b . Unable to tolerate an ACE inhibitor
C. > 65 years old
d . NYHA class II - ANS-a. African American
A common adverse drug reaction from ACE inhibitors prescribed in the setting of heart failure is
a . Reflex tachycardia
b Exacerbation of lower extremity edema
c . Hyperkalemia
d . Elevation of serum glucose in diabetics . - ANS-c . Hyperkalemia
A disadvantage of the antihistamine diphenhydramine ( Benadryl ) is
a . May cause bradycardia
b . Only available by the oral route
c . May cause urinary retention in men with prostate problems
d . Commonly causes diarrhea - ANS-c . May cause urinary retention in men with prostate
problems
A disadvantage to the use of nicotinic acid ( niacin ) for hyperlipidemia is
a . It will decrease the absorption of other oral drugs given simultaneously
b . It is associated with constipation
c . It commonly produces flushing in the face and neck area
d . It may cause a life - threatening myopathy - ANS-c . It commonly produces flushing in the
face and neck area
A drug's therapeutic index can be defined as
a . The drug dosage that produces 100 % of the therapeutic effect
b . The ratio of the average lethal dose of the drug compared to the average effective
therapeutic dose of the drug
c . A measurement of a drugs safety and toxicity
d . The time course of a drugs action - ANS-b . The ratio of the average lethal dose of the drug
compared to the average effective therapeutic dose of the drug
c . A measurement of a drugs safety and toxicity
A middle - aged executive who experienced insomnia with 2 different SSRIs . Which alternative
therapy could relieve insomnia and depression ?
a . MAOI
b . SNRI
c . TCA
d . Benzodiazepine - ANS-c . TCA
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
,N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
A new drug seeking FDA approval has been studied in pregnant rats , rabbits , and mice and
causes birth defects in these fetal animals . There are , however , no studies of this drug in
pregnant women . To which pregnancy risk category does this drug belong ?
a.A
b.B
c.C
d . D - ANS-c. C
A patient presenting to the ER in status epilepticus without IV access can be treated with
a . Fosphenytoin ( cerebyx )
b . Carbamazepine ( tegretol )
c . Lamotrigine ( Lamictal )
d . Phenytoin ( Dilantin ) - ANS-LOOK UP
A patient who took an osmotic laxative on a daily basis could develop this as a consequence
a . An impaction
b . Dehydration
C. Hyperglycemia
d . Hyperkalemia - ANS-b . Dehydration
A patient with phenytoin may exhibit drug toxicity when concurrently taking
a . Cimetidine
b . Famotidine
c . Acetaminophen
d . Aspirin - ANS-a . Cimetidine
A. drug half - life can be defined as
a . The time it takes , after a drug is administered , to reach an effective serum ( or tissue )
concentration that is capable of producing a minimal clinical response
b . The time it takes , after a drug is administered , to reach an effective serum ( or tissue )
concentration capable of producing a maximal clinical response
C. The total time a drug is present in the serum ( or tissue ) for it to produce any clinical effects (
minimal or max )
d . The time it takes , after a drug is administered , to reach an effective serum concentration
equal to one half of what it was at its peak concentration - ANS-d . The time it takes , after a
drug is administered , to reach an effective serum concentration equal to one half of what it was
at its peak concentration
According to JNC - 8 guidelines , which of the following is the blood pressure goal for patients
with diabetes ? CHOOSE ONE ANSWER
a . < 150/90
b . < 140/90
c . < 140/80
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
, N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
d . < 130/85 - ANS-b . < 140/90
According to the FDA , which drug for respiratory illness should not be given to children younger
than 2 years of age
a . Prednisone
b . Albuterol ( Ventolin )
c . N - acetylcysteine ( mucomyst )
d . Dextromethorphan ( delsym ) - ANS-d . Dextromethorphan ( delsym ) *
Administration of an antagonist drug results in
a . No direct pharmacologic action from the drug itself
b . An immediate " wearing out " of the receptors that are blocked by the drug
c. A binding process that causes a permanent alteration in the shape of the receptors
d. Enhanced interaction of the natural endogenous biomediator with the receptor . - ANS-a . No
direct pharmacologic action from the drug itself
Advair diskus contains a combination of
a . Salmeterol and fluticasone
b . Sameterol and acetylcysteine
C. Epinephrine and fluticasone
d . Cromolyn and fluticasone - ANS-a . Salmeterol and fluticasone
Advantages of using a nitrate drug in treatment of angina include
a . Therapy can be individualized because of multiple formulations and mechanism of actions
b . All formulations have a quick onset of action
C. Therapy can be withdrawn quickly without adverse effects
d . Therapy increases myocardial oxygen demand causing a decrease in the heart's workload -
ANS-a . Therapy can be individualized because of multiple formulations and mechanism of
actions
Agonist drugs mimic the actions of the body's exogenous biomediators on their receptors .
Which of the following is an agonist drug ?
a . Milrinone ( Primacor )
b . Atropine
c . Epinephrine
d . Theophylline - ANS-c . Epinephrine
Agonist drugs mimic the actions of the body's exogenous biomediators on their receptors .
Which of the following is an agonist drug ?
a . Milrinone ( Primacor )
b . Atropine
c . Epinephrine
d . Theophylline - ANS-c . Epinephrine
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
N617 Pharm (Exam 1) Summer 2022-Jean Genzale.pdf
