u-uChapteru1-2
Pharmacokineticsu-
uCORRECTuANSWER✔refersutouhowumedicationsutraveluthroughu
theubody,utheyuundergoubiochemicaluprocessesuthaturesultuinuabsorpt
ion,udistribution,umetabolismu&uexcretionu(ADME)
Absorptionu-
uCORRECTuANSWER✔theutransmissionuofumedsufromutheulocatio
nuofuadministrationutoutheubloodstreamu(7uwaysumedsucanubeuabsor
bed)
-
rateuofumeduabsorptionudeterminesuhowusoonutheumeduwillutakeueff
ect
-amountuofumedubodyuabsorbsudeterminesuintensityuofuitsueffects
-urouteuofuadministrationuaffectsurateu&uamountuofuabsorption
Oralu-
uCORRECTuANSWER✔Barriersutouabsorption:umeds.umustupassut
hroughutheulayeruofuepithelialucellsuthatulineutheuGIutract
Absorptionupattern:uvariesugreatlyudueuto:
-stabilityu&usolubilityuofumed
-GIupHu&uemptyingutimeu
-presenceuofufooduinustomach/intestines
, -otheruconcurrentumeds
-formsuofumedsu(enteric-coatedupills,uliquids)
Sublingual,ubuccalu(b/wucheeku&ugum)u-
uCORRECTuANSWER✔Barriersutouabsorption:uswallowingubeforeu
dissolutionuallowsugastricupHutouinactivateutheumed
Absorptionupattern:uquickuabsorptionusystemicallyuthroughuhighlyuva
scularumucousumembranes
Otherumucousumembranesu(rectal,uvaginal)u-
uCORRECTuANSWER✔Barriersutouabsorption:upresenceuofustoolui
nutheurectumuoruinfectiousumaterialuinutheuvaginaulimitsutissueucont
act
Absorptionupattern:ueasyuabsorptionuw/
ubothulocalu&usystemicueffects
Inhalationuviaumouth,unoseu-
uCORRECTuANSWER✔Barriersutouabsorption:uinspiratory
Absorptionupattern:urapiduabsorptionuthroughualveolarucapillaryunetw
orks